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Digital PCR (dPCR) has revolutionized nucleic acid diagnostics by enabling absolute quantification of rare mutations and target sequences. However, current detection methodologies face challenges, as flow cytometers are costly and complex,…

Quantitative Methods · Quantitative Biology 2024-03-29 Yuanyuan Wei , Shanhang Luo , Changran Xu , Yingqi Fu , Qingyue Dong , Yi Zhang , Fuyang Qu , Guangyao Cheng , Yi-Ping Ho , Ho-Pui Ho , Wu Yuan

Absolute quantification of biological samples entails determining expression levels in precise numerical copies, offering enhanced accuracy and superior performance for rare templates. However, existing methodologies suffer from significant…

Quantitative Methods · Quantitative Biology 2023-09-06 Yuanyuan Wei , Sai Mu Dalike Abaxi , Nawaz Mehmood , Luoquan Li , Fuyang Qu , Guangyao Cheng , Dehua Hu , Yi-Ping Ho , Scott Wu Yuan , Ho-Pui Ho

Quantum computing (QC) provides a promising avenue toward enabling quantum chemistry calculations, which are classically impossible due to a computational complexity that increases exponentially with system size. As fully fault-tolerant…

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM's utility. Recently, it has been shown that…

Quantum computers must meet extremely stringent qualitative and quantitative requirements on their qubits in order to solve real-life problems. Quantum circuit fragmentation techniques divide a large quantum circuit into a number of…

Quantum Physics · Physics 2024-06-25 Saikat Basu , Arnav Das , Amit Saha , Amlan Chakrabarti , Susmita Sur-Kolay

Quantum simulation of molecular electronic structure is one of the most promising applications of quantum computing. However, achieving chemically accurate predictions for strongly correlated systems requires quantum phase estimation (QPE)…

Quantum Physics · Physics 2026-03-31 Shota Kanasugi , Riki Toshio , Kazunori Maruyama , Hirotaka Oshima

We develop several algorithms for performing quantum phase estimation based on basic measurements and classical post-processing. We present a pedagogical review of quantum phase estimation and simulate the algorithm to numerically determine…

Quantum Physics · Physics 2013-07-30 Krysta M. Svore , Matthew B. Hastings , Michael Freedman

Parameterised quantum circuits (PQCs) hold great promise for demonstrating quantum advantages in practical applications of quantum computation. Examples of successful applications include the variational quantum eigensolver, the quantum…

Quantum Physics · Physics 2024-04-30 Xin Hong , Wei-Jia Huang , Wei-Chen Chien , Yuan Feng , Min-Hsiu Hsieh , Sanjiang Li , Mingsheng Ying

Motivated by the current COVID-19 health-crisis, we examine the task of baseline subtraction for quantitative polymerase chain-reaction (qPCR) measurements. In particular, we present an algorithm that leverages information obtained from…

Quantitative Methods · Quantitative Biology 2020-04-14 Paul N. Patrone , Anthony J. Kearsley , Erica L. Romsos , Peter M. Vallone

Quantum computing will change the way we tackle certain problems. It promises to dramatically speed-up many chemical, financial, and machine-learning applications. However, to capitalize on those promises, complex design flows composed of…

Quantum Physics · Physics 2020-10-28 Lukas Burgholzer , Robert Wille

Optical phase estimation is a vital measurement primitive that is used to perform accurate measurements of various physical quantities like length, velocity and displacements. The precision of such measurements can be largely enhanced by…

Quantum principal component analysis (QPCA) ignited a new development toward quantum machine learning algorithms. Initially showcasing as an active way for analyzing a quantum system using the quantum state itself, QPCA also found potential…

Quantum Physics · Physics 2025-01-15 Nhat A. Nghiem

Quantum computing is transitioning from experimental prototypes to commercially available turnkey systems, making architecture-agnostic performance metrics essential for cross-platform comparison. Peaked Random Circuits (PRCs) have recently…

Quantum Physics · Physics 2026-05-26 Martin Brieger , Florian Krötz , Minh Chung , Dieter Kranzlmüller

The demonstration of quantum error correction (QEC) is one of the most important milestones in the realization of fully-fledged quantum computers. Toward this, QEC experiments using the surface codes have recently been actively conducted.…

Quantum Physics · Physics 2024-01-12 Mitsuki Katsuda , Kosuke Mitarai , Keisuke Fujii

Simulations of scattering processes are essential in understanding the physics of our universe. Computing relevant scattering quantities from ab initio methods is extremely difficult on classical devices because of the substantial…

Quantum signal processing (QSP) is a powerful quantum algorithm to exactly implement matrix polynomials on quantum computers. Asymptotic analysis of quantum algorithms based on QSP has shown that asymptotically optimal results can in…

Quantum Physics · Physics 2021-07-13 Yulong Dong , Xiang Meng , K. Birgitta Whaley , Lin Lin

Quantum computing offers the promise of speedups for scientific computations, but its application to reacting flows is hindered by nonlinear source terms, the challenges of time-dependent simulations, and the difficulty of extracting…

Quantum Physics · Physics 2026-03-17 Jizhi Zhang , Ziang Yang , Zhaoyuan Meng , Zhen Lu , Yue Yang

Simulating the unitary dynamics of a quantum system is a fundamental problem of quantum mechanics, in which quantum computers are believed to have significant advantage over their classical counterparts. One prominent such instance is the…

Quantum Physics · Physics 2024-09-04 John M. Martyn , Yuan Liu , Zachary E. Chin , Isaac L. Chuang

Quantum algorithms for simulating electronic ground states are slower than popular classical mean-field algorithms such as Hartree-Fock and density functional theory, but offer higher accuracy. Accordingly, quantum computers have been…

This work introduces a novel quantum algorithm for gradient-based edge detection that operates entirely within the quantum circuit model. Grayscale images are encoded using the Novel Enhanced Quantum Representation (NEQR), allowing exact…

Quantum Physics · Physics 2026-04-30 Fred Sun
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