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Modeling the interactions between drugs, targets, and diseases is paramount in drug discovery and has significant implications for precision medicine and personalized treatments. Current approaches frequently consider drug-target or…

Machine Learning · Computer Science 2023-12-04 Farhan Tanvir , Khaled Mohammed Saifuddin , Tanvir Hossain , Arunkumar Bagavathi , Esra Akbas

Heterogeneous graph neural network (HGNN) is a very popular technique for the modeling and analysis of heterogeneous graphs. Most existing HGNN-based approaches are supervised or semi-supervised learning methods requiring graphs to be…

Machine Learning · Computer Science 2023-11-17 Cuiying Huo , Dongxiao He , Yawen Li , Di Jin , Jianwu Dang , Weixiong Zhang , Witold Pedrycz , Lingfei Wu

Interacting systems are ubiquitous in nature and engineering, ranging from particle dynamics in physics to functionally connected brain regions. These interacting systems can be modeled by graphs where edges correspond to the interactions…

Machine Learning · Computer Science 2024-01-25 Zhichao Han , Olga Fink , David S. Kammer

Real-world networks and knowledge graphs are usually heterogeneous networks. Representation learning on heterogeneous networks is not only a popular but a pragmatic research field. The main challenge comes from the heterogeneity -- the…

Social and Information Networks · Computer Science 2021-02-17 Jie Zhang , Jinru Ding , Suyuan Liu , Hongyan Wu

Networks are frequently used to model complex systems comprised of interacting elements. While edges capture the topology of direct interactions, the true complexity of many systems originates from higher-order patterns in paths by which…

Social and Information Networks · Computer Science 2022-10-04 Christoph Gote , Vincenzo Perri , Ingo Scholtes

Embedding network data into a low-dimensional vector space has shown promising performance for many real-world applications, such as node classification and entity retrieval. However, most existing methods focused only on leveraging network…

Social and Information Networks · Computer Science 2019-07-02 Lizi Liao , Xiangnan He , Hanwang Zhang , Tat-Seng Chua

Graph Neural Networks (GNNs) are characterized by their capacity of processing graph-structured data. However, due to the sparsity of labels under semi-supervised learning, they have been found to exhibit biased performance on specific…

Machine Learning · Computer Science 2025-12-16 Yihan Zhang

Meta-graph is currently the most powerful tool for similarity search on heterogeneous information networks,where a meta-graph is a composition of meta-paths that captures the complex structural information. However, current relevance…

Social and Information Networks · Computer Science 2018-09-13 Lichao Sun , Lifang He , Zhipeng Huang , Bokai Cao , Congying Xia , Xiaokai Wei , Philip S. Yu

Heterogeneous graphs (HGs) are common in real-world scenarios and often exhibit heterophily. However, most existing studies focus on either heterogeneity or heterophily in isolation, overlooking the prevalence of heterophilic HGs in…

Machine Learning · Computer Science 2025-08-11 Qin Chen , Guojie Song

Graph Transformers have recently achieved remarkable progress in graph representation learning by capturing long-range dependencies through self-attention. However, their quadratic computational complexity and inability to effectively model…

Machine Learning · Computer Science 2025-12-17 Yifan Lu , Ziyun Zou , Belal Alsinglawi , Islam Al-Qudah , Izzat Alsmadi , Feilong Tang , Pengfei Jiao , Shoaib Jameel , Imran Razzak

Homophily, the tendency of similar nodes to connect, is a fundamental phenomenon in network science and a critical factor in the performance of graph neural networks (GNNs). While existing studies primarily explore homophily in homogeneous…

Social and Information Networks · Computer Science 2025-11-18 Zhen Tao , Ziyue Qiao , Chaoqi Chen , Zhengyi Yang , Lun Du , Qingqiang Sun

Graph neural networks (GNNs) have emerged as a powerful tool for modeling graph-structured data. However, existing GNNs often struggle with heterophilic graphs, where connected nodes tend to have dissimilar features or labels. While…

Machine Learning · Computer Science 2025-09-17 Ruizhong Qiu , Ting-Wei Li , Gaotang Li , Hanghang Tong

Heterogeneous graph representation learning aims to learn low-dimensional vector representations of different types of entities and relations to empower downstream tasks. Existing methods either capture semantic relationships but indirectly…

Machine Learning · Computer Science 2025-08-14 Hao Xu , Shengqi Sang , Peizhen Bai , Laurence Yang , Haiping Lu

Self-supervised heterogeneous graph learning (SHGL) has shown promising potential in diverse scenarios. However, while existing SHGL methods share a similar essential with clustering approaches, they encounter two significant limitations:…

Artificial Intelligence · Computer Science 2024-12-03 Yujie Mo , Zhihe Lu , Runpeng Yu , Xiaofeng Zhu , Xinchao Wang

Recent years have witnessed the emerging success of graph neural networks (GNNs) for modeling structured data. However, most GNNs are designed for homogeneous graphs, in which all nodes and edges belong to the same types, making them…

Machine Learning · Computer Science 2020-03-04 Ziniu Hu , Yuxiao Dong , Kuansan Wang , Yizhou Sun

Graph neural networks (GNNs) have emerged as the state of the art for a variety of graph-related tasks and have been widely used in Heterogeneous Graphs (HetGs), where meta-paths help encode specific semantics between various node types.…

Machine Learning · Computer Science 2025-02-25 Xuqi Mao , Zhenying He , X. Sean Wang

Heterogeneous graph neural networks (HGNNs) were proposed for representation learning on structural data with multiple types of nodes and edges. To deal with the performance degradation issue when HGNNs become deep, researchers combine…

Machine Learning · Computer Science 2023-11-27 Xinyu Fu , Irwin King

Existing multiplex graph models often assume homophily, where connected nodes tend to belong to the same class or share similar attributes. Consequently, these models may struggle with graphs exhibiting heterophily, where connected nodes…

Machine Learning · Computer Science 2026-05-14 Kamel Abdous , Nairouz Mrabah , Mohamed Bouguessa

Self-supervised learning (SSL) methods have been increasingly applied to diverse downstream tasks due to their superior generalization capabilities and low annotation costs. However, most existing heterogeneous graph SSL models convert…

Machine Learning · Computer Science 2025-06-10 Di Lin , Wanjing Ren , Xuanbin Li , Rui Zhang

Graph neural networks (GNNs) have emerged as a powerful tool for modeling graph-structured data. However, existing GNNs often struggle with heterophilic graphs, where connected nodes tend to have dissimilar features or labels. While…

Machine Learning · Computer Science 2026-02-10 Ruizhong Qiu , Ting-Wei Li , Gaotang Li , Hanghang Tong
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