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\noindent\textbf{Background} Prenatal glucocorticoid exposure alters cardiac development, but whether persistent cardiac effects in childhood follow a dose-response relationship remains unknown. We recently showed that ECG foundation models…

Quantitative Methods · Quantitative Biology 2026-03-05 Nicolas B. Garnier , Michelle Dreiling , Valeska Kozik , Matthias Schwab , Florian Rakers , Martin G Frasch

A second wave of SARS-CoV-2 is unfolding in dozens of countries. However, this second wave manifests itself strongly in new reported cases, but less in death counts compared to the first wave. Over the past three months in Germany, the…

Populations and Evolution · Quantitative Biology 2020-10-28 Matthias Linden , Jonas Dehning , Sebastian B. Mohr , Jan Mohring , Michael Meyer-Hermann , Iris Pigeot , Anita Schöbel , Viola Priesemann

Adverse childhood experiences (ACEs) are categories of childhood abuse, neglect, and household dysfunction. Screening by a single additive ACE score (e.g., a $\ge 4$ cutoff) has poor individual-level discrimination. We instead identify…

Applications · Statistics 2025-11-26 Ruizhe Zhang , Jooyoung Kong , Dylan S. Small , William Bekerman

The outbreak of a novel coronavirus causing severe acute respiratory syndrome in December 2019 has escalated into a worldwide pandemic. In this work, we propose a compartmental model to describe the dynamics of transmission of infection and…

Optimization and Control · Mathematics 2022-10-25 Eleni Zavrakli , Andrew Parnell , David Malone , Ken Duffy , Subhrakanti Dey

Diabetes is considered as an critical comorbidity linked with the latest coronavirus disease 2019 (COVID-19) which spreads through Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2). The diabetic patients have higher threat of…

Other Quantitative Biology · Quantitative Biology 2022-04-07 Amit M. Joshi , Urvashi P. Shukla , Saraju P. Mohanty

There is increasing evidence that infection with SARS-CoV-2 can cause a spectrum of neurological symptoms. In this paper, we develop a theoretical concept underlying such neurological COVID-19 consequences by employing a non-equilibrium…

Medical Physics · Physics 2021-11-09 Umberto Lucia , Giulia Grisolia , Thomas S. Deisboeck

In light of the continuing emergence of new SARS-CoV-2 variants and vaccines, we create a simulation framework for exploring possible infection trajectories under various scenarios. The situations of primary interest involve the interaction…

Populations and Evolution · Quantitative Biology 2022-01-10 Kory D. Johnson , Annemarie Grass , Daniel Toneian , Mathias Beiglböck , Jitka Polechová

The wide spread of coronavirus disease 2019 (COVID-19) has declared a global health emergency. As one of the most important targets for antibody and drug developments, Spike RBD-ACE2 interface has received extensive attention. Here, using…

Biomolecules · Quantitative Biology 2021-05-14 Yanmei Yang , Yunju Zhang , Yuanyuan Qu , Xuewei Liu , Mingwen Zhao , Yuguang Mu , Weifeng Li

The reason of significantly higher transmissibility of SARS Covid (2019 CoV-2) compared to SARS Covid (2003 CoV) and MERS Covid (2012 MERS) can be attributed to mutations reported in structural proteins, and the role played by…

Biomolecules · Quantitative Biology 2022-02-25 Raju Hazari , P Pal Chaudhuri

The current work is done to see which artery has more chance of having cardiovascular diseases by measuring value of pressure gradient in the common carotid artery (CCA) and ascending aorta according to age and gender. Pressure gradient is…

Medical Physics · Physics 2017-06-02 Renu Saini , Sharda Vashisth , Ruchika Bhatia

The debate on the role of school closures as a mitigation strategy against the spread of Covid-19 is gaining relevance due to emerging variants in Europe. According to WHO, decisions on schools "should be guided by a risk-based approach".…

Populations and Evolution · Quantitative Biology 2021-05-14 R. Battiston , F. Carinci , A. Ferretti , R. Iuppa , G. Lattanzi , D. Menasce , S. Merler , M. Mezzetto , R. Potestio , G. Salina , C. Spinella , S. Tonini , L. Tubiana , Y. Velegrakis , R. De Vogli

The coronavirus SARS-CoV-2 remains an extant threat against public health on a global scale. Cell infection begins when the spike protein of SARS-CoV-2 binds with the cell receptor, angiotensin-converting enzyme 2 (ACE2). Here, we address…

Biomolecules · Quantitative Biology 2021-02-24 Tom Y. Zhao , Neelesh A. Patankar

The crisis caused by the COVID-19 outbreak around the globe raised an increasing concern about the ongoing emergence of variants of SARS-CoV-2 that may evade the immune response provided by vaccines. New variants appear due to mutation, and…

Populations and Evolution · Quantitative Biology 2022-12-14 M. Ahumada , A. Ledesma-Araujo , Leonardo Gordillo , Juan F. Marín

The mitigation of an infectious disease spreading has recently gained considerable attention from the research community. It may be obtained by adopting sanitary measurements social rules, together with an extensive vaccination campaign.…

Social and Information Networks · Computer Science 2022-02-17 Francesco Petrizzelli , Pietro Hiram Guzzi , Tommaso Mazza

Hypertension is one of the most common age-related chronic diseases and by predisposing individuals for heart failure, stroke and kidney disease, it is a major source of morbidity and mortality. Its etiology remains enigmatic despite…

Tissues and Organs · Quantitative Biology 2015-06-15 Klas H. Pettersen , Scott M. Bugenhagen , Javaid Nauman , Daniel A. Beard , Stig W. Omholt

We describe several shortcomings of a study by Patone et al, whose findings were recently published in the American Heart Association Journal Circulation, including the following: * The study's principal conclusion, as initially stated,…

Quantitative Methods · Quantitative Biology 2023-03-27 Paul S. Bourdon , Spiro Pantazatos

COVID-19 is a devastating respiratory and inflammatory illness caused by a new coronavirus that is rapidly spreading throughout the human population. Over the past 6 months, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the…

Understanding the behaviour of hosts of SARS-CoV-2 is crucial to our understanding of the virus. A comparison of environmental features related to the incidence of SARS-CoV-2 with those of its potential hosts is critical. We examine the…

Adverse Childhood Experiences (ACEs) are defined as a collection of highly stressful, and potentially traumatic, events or circumstances that occur throughout childhood and/or adolescence. They have been shown to be associated with…

Computation and Language · Computer Science 2022-08-25 Jinge Wu , Rowena Smith , Honghan Wu

The SARS-CoV2 virus has caused a lot of tribulation to the human population. Predictive modeling that can accurately determine whether a person is infected with COVID-19 is imperative. The study proposes a novel approach that utilizes deep…

Image and Video Processing · Electrical Eng. & Systems 2021-11-23 Jash Dalvi , Aziz Bohra
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