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Over the past few decades, neuroscience experiments have become increasingly complex and naturalistic. Experimental design has in turn become more challenging, as experiments must conform to an ever-increasing diversity of design…

Neurons and Cognition · Quantitative Biology 2020-12-07 Storm Slivkoff , Jack L. Gallant

Machine learning components commonly appear in larger decision-making pipelines; however, the model training process typically focuses only on a loss that measures accuracy between predicted values and ground truth values. Decision-focused…

Machine Learning · Computer Science 2019-07-19 Aaron Ferber , Bryan Wilder , Bistra Dilkina , Milind Tambe

Mixed-integer programming (MIP) technology offers a generic way of formulating and solving combinatorial optimization problems. While generally reliable, state-of-the-art MIP solvers base many crucial decisions on hand-crafted heuristics,…

Machine Learning · Computer Science 2022-05-31 Elias B. Khalil , Christopher Morris , Andrea Lodi

With the accelerated development of Industry 4.0, intelligent manufacturing systems increasingly require efficient task allocation and scheduling in multi-robot systems. However, existing methods rely on domain expertise and face challenges…

Artificial Intelligence · Computer Science 2025-03-19 Mingming Peng , Zhendong Chen , Jie Yang , Jin Huang , Zhengqi Shi , Qihao Liu , Xinyu Li , Liang Gao

Mixed-integer optimization is at the core of many online decision-making systems that demand frequent updates of decisions in real time. However, due to their combinatorial nature, mixed-integer linear programs (MILPs) can be difficult to…

Optimization and Control · Mathematics 2026-04-21 Shivi Dixit , Rishabh Gupta , Qi Zhang

We survey recent work on machine learning (ML) techniques for selecting cutting planes (or cuts) in mixed-integer linear programming (MILP). Despite the availability of various classes of cuts, the task of choosing a set of cuts to add to…

Optimization and Control · Mathematics 2023-11-01 Arnaud Deza , Elias B. Khalil

Multi-product pipelines are a highly efficient means of transporting liquids. Traditionally used to transport petroleum, its products and derivatives, they are now being repurposed to transport liquified natural gas admixed with hydrogen of…

Optimization and Control · Mathematics 2023-12-19 Ales Wodecki , Pavel Rytir , Vyacheslav Kungurtsev , Jakub Marecek

Mixed-integer linear programming (MILP) has been a fundamental problem in combinatorial optimization. Conventional MILP solving mainly relies on carefully designed heuristics embedded in the branch-and-bound framework. Driven by the strong…

Artificial Intelligence · Computer Science 2026-01-13 Siyuan Li , Yifan Yu , Zhihao Zhang , Mengjing Chen , Fangzhou Zhu , Tao Zhong , Peng Liu , Jianye Hao

Following the recent push for trustworthy AI, there has been an increasing interest in developing contrastive explanation techniques for optimisation, especially concerning the solution of specific decision-making processes formalised as…

Artificial Intelligence · Computer Science 2025-07-18 Roger Xavier Lera-Leri , Filippo Bistaffa , Athina Georgara , Juan Antonio Rodriguez-Aguilar

This paper surveys the trend of leveraging machine learning to solve mixed integer programming (MIP) problems. Theoretically, MIP is an NP-hard problem, and most of the combinatorial optimization (CO) problems can be formulated as the MIP.…

Artificial Intelligence · Computer Science 2022-03-08 Jiayi Zhang , Chang Liu , Junchi Yan , Xijun Li , Hui-Ling Zhen , Mingxuan Yuan

We present a bounded model checking algorithm for signal temporal logic (STL) that exploits mixed-integer linear programming (MILP). A key technical element is our novel MILP encoding of the STL semantics; it follows the idea of stable…

Systems and Control · Electrical Eng. & Systems 2024-08-14 Sota Sato , Jie An , Zhenya Zhang , Ichiro Hasuo

Mixed-Integer Linear Programming (MILP) is a foundational tool for complex decision-making problems. However, the NP-hard nature of MILP presents a significant computational challenge, motivating the development of machine learning-based…

Optimization and Control · Mathematics 2026-03-03 Hongpei Li , Hui Yuan , Han Zhang , Jianghao Lin , Dongdong Ge , Mengdi Wang , Yinyu Ye

Recent growing complexity in space missions has led to an active research field of space logistics and mission design. This research field leverages the key ideas and methods used to handle complex terrestrial logistics to tackle space…

Optimization and Control · Mathematics 2025-08-27 Koki Ho , Yuri Shimane , Masafumi Isaji

This paper deals with a distributed Mixed-Integer Linear Programming (MILP) set-up arising in several control applications. Agents of a network aim to minimize the sum of local linear cost functions subject to both individual constraints…

Optimization and Control · Mathematics 2021-02-12 Andrea Camisa , Ivano Notarnicola , Giuseppe Notarstefano

Constraint Programming (CP) users need significant expertise in order to model their problems appropriately, notably to select propagators and search strategies. This puts the brakes on a broader uptake of CP. In this paper, we introduce…

Artificial Intelligence · Computer Science 2016-11-29 Thierry Petit

We propose a supervised learning framework for computing solutions of multi-parametric Mixed Integer Linear Programs (MILPs) that arise in Model Predictive Control. Our approach also quantifies sub-optimality for the computed solutions.…

Systems and Control · Electrical Eng. & Systems 2023-03-24 Luigi Russo , Siddharth H. Nair , Luigi Glielmo , Francesco Borrelli

Cutting planes (cuts) are crucial for solving Mixed Integer Linear Programming (MILP) problems. Advanced MILP solvers typically rely on manually designed heuristic algorithms for cut selection, which require much expert experience and…

Optimization and Control · Mathematics 2024-12-11 Xuefeng Zhang , Liangyu Chen , Zhengfeng Yang , Zhenbing Zeng

In this work, we address a task allocation problem for human multi-robot settings. Given a set of tasks to perform, we formulate a general Mixed-Integer Linear Programming (MILP) problem aiming at minimizing the overall execution time while…

Robotics · Computer Science 2021-09-20 Martina Lippi , Alessandro Marino

Mixed-Integer Linear Programming (MILP) is a cornerstone of combinatorial optimization, yet solving large-scale instances remains a significant computational challenge. Recently, Graph Neural Networks (GNNs) have shown promise in…

Machine Learning · Computer Science 2025-11-13 Tianle Pu , Jianing Li , Yingying Gao , Shixuan Liu , Zijie Geng , Haoyang Liu , Chao Chen , Changjun Fan

Global optimization of decision trees is a long-standing challenge in combinatorial optimization, yet such models play an important role in interpretable machine learning. Although the problem has been investigated for several decades, only…

Machine Learning · Computer Science 2026-02-03 Jiancheng Tu , Wenqi Fan , Zhibin Wu