Related papers: Viscocapillary Instability in Cellular Spheroids
The stability of a flexible fluid membrane containing a distribution of mobile, active proteins (e.g. proton pumps) is shown to depend on the structure and functional asymmetry of the proteins. A stable active membrane is in a…
Recent experimental observations have demonstrated interesting instability phenomenon during thermal drawing of microstructured glass/polymer fibers, and these observations motivate us to examine surface-tension-driven instabilities in…
Cellularized tissue and polymer networks can both transition from floppy to rigid as a function of their control parameters, and, yet, the two systems often mechanically interact, which may affect their respective rigidities. To study this…
Collective cell migration plays a crucial role in many developmental processes that underlie morphogenesis, wound healing, or cancer progression. In such coordinated behaviours, cells are organised in coherent structures and actively…
We study theoretically the shapes of biological tubes affected by various pathologies. When epithelial cells grow at an uncontrolled rate, the negative tension produced by their division provokes a buckling instability. Several shapes are…
The stability of convection rolls in a fluid heated from below is limited by secondary instabilities, including the skew-varicose and crossroll instabilities. We observe a stability boundary defined by the same instabilities in stripe…
Tumour spheroids have the potential to be used as preclinical chemosensitivity assays. However, the production of three dimensional (3D) tumour spheroids remains challenging as not all tumour cell lines form spheroids with regular…
Understanding the phase behavior of mixtures with many components is important in many contexts, including as a key step toward a physics-based description of intracellular compartmentalization. Here, we study the instabilities of a mixture…
Complex fluids such as emulsions, colloidal gels, polymer or surfactant solutions are all characterized by the existence of a "microstructure" which may couple to an external flow on timescales that are easily probed in experiments. Such a…
Invasiveness, one of the hallmarks of tumor progression, represents the tumor's ability to expand into the host tissue by means of several complex biochemical and biomechanical processes. Since certain aspects of the problem present a…
Tumor growth is constrained by spatial, mechanical, and metabolic factors whose alignment progressively breaks down across cellular, mesoscopic, and tissue scales as tumors expand. We hypothesize that this misalignment drives tumors toward…
Tumour spheroids have been the focus of a variety of mathematical models, ranging from Greenspan's classical study of the 1970s through to contemporary agent-based models. Of the many factors that regulate spheroid growth, mechanical…
Solid tumours have the ability to assemble their own vascular network for optimizing their access to the vital nutrients. These new capillaries are morphologically different from normal physiological vessels. In particular, they have a much…
Addition of particles to a viscoelastic suspension dramatically alters the properties of the mixture, particularly when it is sheared or otherwise processed. Shear-induced stretching of the polymers results in elastic stress that causes a…
Active-elastic instabilities are common phenomena in the natural world which have the aspect of sudden mechanical morphings. Frequently, the driving force of the instability mechanisms has a chemo-mechanical nature which makes these kind of…
It is widely recognized that reciprocal interactions between cells and their microenvironment, via mechanical forces and biochemical signaling pathways, regulate cell behaviors during normal development, homeostasis and disease progression…
We examine the role of anisotropic turbulence on the shear instabilities in a stratified flow. Such turbulence is expected to occur in the radiative interiors of stars, due to their differential rotation and their strong stratification, and…
We study multicellular tumor spheroids by introducing a new three-dimensional agent-based Voronoi/Delaunay hybrid model. In this model, the cell shape varies from spherical in thin solution to convex polyhedral in dense tissues. The next…
Interfacial instability would be aroused on a spherical liquid droplet when it is subject to external vertical vibration. In this paper, a linear analysis was conducted on this instability problem. The polar-angle dependent acceleration in…
Layered accretion is one of the inevitable ingredients in protoplanetary disks when disk turbulence is excited by magnetorotational instabilities (MRIs). In the accretion, disk surfaces where MRIs fully operate have a high value of disk…