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Facing a global epidemic of new infectious diseases such as COVID-19, non-pharmaceutical interventions (NPIs), which reduce transmission rates without medical actions, are being implemented around the world to mitigate spreads. One of the…

Populations and Evolution · Quantitative Biology 2021-03-04 Naoya Fujiwara , Tomokatsu Onaga , Takayuki Wada , Shouhei Takeuchi , Junji Seto , Tomoki Nakaya , Kazuyuki Aihara

Non-pharmaceutical interventions (NPIs) such as quarantine, self-isolation, social distancing, and virus-contact tracing can greatly reduce the spread of the virus during a pandemic. In the wave of the COVID-19 pandemic, many countries have…

Physics and Society · Physics 2020-12-16 Jingjing He , Xuefei Guan , Xiaochang Duan , Tian Shen , Jing Lin

Countries around the world implement nonpharmaceutical interventions (NPIs) to mitigate the spread of COVID-19. Design of efficient NPIs requires identification of the structure of the disease transmission network. We here identify the key…

Populations and Evolution · Quantitative Biology 2021-05-18 Simon Syga , Diana David-Rus , Yannik Schälte , Michael Meyer-Hermann , Haralampos Hatzikirou , Andreas Deutsch

Background: The impact of individual non-pharmaceutical interventions (NPI) such as state-wide stay-at-home orders, school closures and gathering size limitations, on the COVID-19 epidemic is unknown. Understanding the impact that above…

Populations and Evolution · Quantitative Biology 2020-07-27 Ian E. Fellows , Rachel B. Slayton , Avi J. Hakim

This study investigates the influence of different types of non-pharmaceutical interventions (NPIs) on epidemic progression using SIR compartmental models. We analyze the optimization of two distinct targets: the final epidemic size and the…

Populations and Evolution · Quantitative Biology 2026-04-10 Eric Rozán , Marcelo N Kuperman , Sebastián Bouzat

Non-pharmaceutical interventions (NPIs), including mask-wearing, physical distancing, and hygiene measures, provide the primary means of reducing transmission in the early stages of an epidemic. Individuals adopt one of two…

Populations and Evolution · Quantitative Biology 2026-05-22 Yuan Liu , Michael Sieber , Bin Wu , Arne Traulsen

Non-pharmaceutical interventions(NPIs) play an important role in the early stage control of COVID-19 pandemic. Vaccination is considered to be the inevitable course to stop the spread of SARS-CoV-2. Based on the mechanism, a SVEIR COVID-19…

Populations and Evolution · Quantitative Biology 2021-07-08 Bin-Guo Wang , Shunxiang Huang , Yongping Xiong , Ming-Zhen Xin , Jing LI , Jiangqian Zhang , Zhihui Ma

To date, the only effective means to respond to the spreading of COVID-19 pandemic are non-pharmaceutical interventions (NPIs), which entail policies to reduce social activity and mobility restrictions. Quantifying their effect is…

Physics and Society · Physics 2021-03-01 Francesco Parino , Lorenzo Zino , Maurizio Porfiri , Alessandro Rizzo

This paper introduces a dynamic panel SIR (DP-SIR) model to investigate the impact of non-pharmaceutical interventions (NPIs) on the COVID-19 transmission dynamics with panel data from 9 countries across the globe. By constructing scenarios…

Populations and Evolution · Quantitative Biology 2021-06-07 Xiaohui Chen , Ziyi Qiu

During the recent pandemic, a rise in COVID-19 cases was followed by a decline in influenza. In the absence of cross-immunity, a potential explanation for the observed pattern is behavioral: non-pharmaceutical interventions (NPIs) designed…

Dynamical Systems · Mathematics 2026-04-20 Leah LeJeune , Omar Saucedo , Lauren M. Childs , Navid Ghaffarzadegan

To what extent are effectiveness estimates of nonpharmaceutical interventions (NPIs) against COVID-19 influenced by the assumptions our models make? To answer this question, we investigate 2 state-of-the-art NPI effectiveness models and…

Infectious diseases and human behavior are intertwined. On one side, our movements and interactions are the engines of transmission. On the other, the unfolding of viruses might induce changes to our daily activities. While intuitive, our…

Physics and Society · Physics 2021-06-02 Nicola Perra

Our study is based on an epidemiological compartmental model, the SIRS model. In the SIRS model, each individual is in one of the states susceptible (S), infected(I) or recovered (R), depending on its state of health. In compartment R, an…

Populations and Evolution · Quantitative Biology 2023-05-10 Michael Bestehorn , Thomas M. Michelitsch

In fighting infectious diseases posing a global health threat, ranging from influenza to Zika, non-pharmaceutical interventions (NPI), such as social distancing and face covering, remain mitigation measures public health can resort to.…

Physics and Society · Physics 2024-04-12 Alina Glaubitz , Feng Fu

In this research, we have derived a mathematical model for within human dynamics of COVID-19 infection using delay differential equations. The new model considers a 'latent period' and 'the time for immune response' as delay parameters,…

Populations and Evolution · Quantitative Biology 2025-01-14 Amar N. Chatterjee , Teklebirhan Abraha , Fahad Al Basir , Delfim F. M. Torres

When an infectious disease propagates throughout society, the incidence function may rise at first due to an increase in pathogenicity and then decrease due to inhibitory effects until it reaches saturation. Effective vaccination and…

Dynamical Systems · Mathematics 2023-07-11 Sushil Pathak , G. Shirisha , K. Venkata Ratnam

Pharmaceutical and non-pharmaceutical interventions (NPIs) have been crucial for controlling COVID-19. They are complemented by voluntary health-protective behaviour, building a complex interplay between risk perception, behaviour, and…

We propose a general Bayesian approach to modeling epidemics such as COVID-19. The approach grew out of specific analyses conducted during the pandemic, in particular an analysis concerning the effects of non-pharmaceutical interventions…

Applications · Statistics 2021-01-01 Samir Bhatt , Neil Ferguson , Seth Flaxman , Axel Gandy , Swapnil Mishra , James A. Scott

As a reaction to the high infectiousness and lethality of the COVID-19 virus, countries around the world have adopted drastic policy measures to contain the pandemic. However, it remains unclear which effect these measures, so-called…

Computers and Society · Computer Science 2021-08-11 Lucas Baier , Niklas Kühl , Jakob Schöffer , Gerhard Satzger

Non-pharmaceutical interventions (NPIs) have been crucial in curbing COVID-19 in the United States (US). Consequently, relaxing NPIs through a phased re-opening of the US amid still-high levels of COVID-19 susceptibility could lead to new…

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