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AI algorithms have become valuable in aiding professionals in healthcare. The increasing confidence obtained by these models is helpful in critical decision demands. In clinical dermatology, classification models can detect malignant…

Cell detection, segmentation and classification are essential for analyzing tumor microenvironments (TME) on hematoxylin and eosin (H&E) slides. Existing methods suffer from poor performance on understudied cell types (rare or not present…

Deep learning has achieved unprecedented success in various object detection tasks with huge amounts of labeled data. However, obtaining large-scale annotations for medical images is extremely challenging due to the high demand of labour…

Image and Video Processing · Electrical Eng. & Systems 2022-03-21 Zhizhong Chai , Luyang Luo , Huangjing Lin , Hao Chen , Anjia Han , Pheng-Ann Heng

The gene expression profile of a tissue averages the expression profiles of all cells in this tissue. Digital tissue deconvolution (DTD) addresses the following inverse problem: Given the expression profile $y$ of a tissue, what is the…

Quantitative Methods · Quantitative Biology 2018-06-13 Franziska Görtler , Stefan Solbrig , Tilo Wettig , Peter J. Oefner , Rainer Spang , Michael Altenbuchinger

Species distribution modeling is a highly versatile tool for understanding the intricate relationship between environmental conditions and species occurrences. However, the available data often lacks information on confirmed species absence…

Quantitative Methods · Quantitative Biology 2024-06-18 Robin Zbinden , Nina van Tiel , Benjamin Kellenberger , Lloyd Hughes , Devis Tuia

This study is about inducing classifiers using data that is imbalanced, with a minority class being under-represented in relation to the majority classes. The first section of this research focuses on the main characteristics of data that…

Machine Learning · Computer Science 2022-10-25 Shivaditya Shivganesh , Nitin Narayanan N , Pranav Murali , Ajaykumar M

Highly imbalanced datasets are ubiquitous in medical image classification problems. In such problems, it is often the case that rare classes associated to less prevalent diseases are severely under-represented in labeled databases,…

Computer Vision and Pattern Recognition · Computer Science 2022-09-15 Adrian Galdran , Gustavo Carneiro , Miguel A. González Ballester

Recent advancements in deep learning have brought significant improvements to plant disease recognition. However, achieving satisfactory performance often requires high-quality training datasets, which are challenging and expensive to…

Computer Vision and Pattern Recognition · Computer Science 2023-12-14 Mingle Xu , Hyongsuk Kim , Jucheng Yang , Alvaro Fuentes , Yao Meng , Sook Yoon , Taehyun Kim , Dong Sun Park

The purpose of this research report is to present the our learning curve and the exposure to the Machine Learning life cycle, with the use of a Kaggle binary classification data set and taking to explore various techniques from…

Machine Learning · Computer Science 2021-05-25 Mohamed Hamama

Single-cell datasets often lack individual cell labels, making it challenging to identify cells associated with disease. To address this, we introduce Mixture Modeling for Multiple Instance Learning (MMIL), an expectation maximization…

Quantitative Methods · Quantitative Biology 2024-06-13 Erin Craig , Timothy Keyes , Jolanda Sarno , Maxim Zaslavsky , Garry Nolan , Kara Davis , Trevor Hastie , Robert Tibshirani

Metagenomic studies have increasingly utilized sequencing technologies in order to analyze DNA fragments found in environmental samples.One important step in this analysis is the taxonomic classification of the DNA fragments. Conventional…

Genomics · Quantitative Biology 2020-02-11 Andreas Georgiou , Vincent Fortuin , Harun Mustafa , Gunnar Rätsch

Datasets are rarely a realistic approximation of the target population. Say, prevalence is misrepresented, image quality is above clinical standards, etc. This mismatch is known as sampling bias. Sampling biases are a major hindrance for…

Semi-supervised learning has made significant strides in the medical domain since it alleviates the heavy burden of collecting abundant pixel-wise annotated data for semantic segmentation tasks. Existing semi-supervised approaches enhance…

Computer Vision and Pattern Recognition · Computer Science 2021-12-03 Xu Zheng , Chong Fu , Haoyu Xie , Jialei Chen , Xingwei Wang , Chiu-Wing Sham

Detecting and segmenting individual cells from microscopy images is critical to various life science applications. Traditional cell segmentation tools are often ill-suited for applications in brightfield microscopy due to poor contrast and…

Image and Video Processing · Electrical Eng. & Systems 2020-05-20 Rituparna Sarkar , Suvadip Mukherjee , Elisabeth Labruyère , Jean-Christophe Olivo-Marin

Heterogeneity is a hallmark of complex diseases. Regression-based heterogeneity analysis, which is directly concerned with outcome-feature relationships, has led to a deeper understanding of disease biology. Such an analysis identifies the…

Methodology · Statistics 2022-11-29 Ziye Luo , Xinyue Yao , Yifan Sun , Xinyan Fan

Data rebalancing techniques, including oversampling and undersampling, are a common approach to addressing the challenges of imbalanced data. To tackle unresolved problems related to both oversampling and undersampling, we propose a new…

Machine Learning · Computer Science 2025-07-11 Karen Medlin , Sven Leyffer , Krishnan Raghavan

Microscopy images from different imaging conditions, organs, and tissues often have numerous cells with various shapes on a range of backgrounds. As a result, designing a deep learning model to count cells in a source domain becomes…

Computer Vision and Pattern Recognition · Computer Science 2023-03-21 Zuhui Wang

Type 2 Diabetes is a fast-growing, chronic metabolic disorder due to imbalanced insulin activity.The motion of this research is a comparative study of seven machine learning classifiers and an artificial neural network method to…

Machine Learning · Computer Science 2023-01-10 Md. Kowsher , Mahbuba Yesmin Turaba , Tanvir Sajed , M M Mahabubur Rahman

Background and objective: Cell-level pathological image analysis requires working with extremely small image patches (40x40 pixels), far below standard ImageNet resolutions. It remains unclear whether modern deep learning architectures and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Hiroki Kagiyama , Toru Nagasaka , Yukari Adachi , Takaaki Tachibana , Ryota Ito , Mitsugu Fujita , Kimihiro Yamashita , Yoshihiro Kakeji

This study proposes an efficient neural network with convolutional layers to classify significantly class-imbalanced clinical data. The data are curated from the National Health and Nutritional Examination Survey (NHANES) with the goal of…

Quantitative Methods · Quantitative Biology 2020-04-24 Aniruddha Dutta , Tamal Batabyal , Meheli Basu , Scott T. Acton
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