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We present a novel method for quantifying the microscopic structure of brain tissue. It is based on the automated recognition of interpretable features obtained by analyzing the shapes of cells. This contrasts with prevailing methods of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-10 Kui Qian , Litao Qiao , Beth Friedman , Edward O'Donnell , David Kleinfeld , Yoav Freund

Surrogate task based methods have recently shown great promise for unsupervised image anomaly detection. However, there is no guarantee that the surrogate tasks share the consistent optimization direction with anomaly detection. In this…

Computer Vision and Pattern Recognition · Computer Science 2020-12-10 Fei Ye , Huangjie Zheng , Chaoqin Huang , Ya Zhang

Autism Spectrum Disorder (ASD) is a multi-factorial neurodevelopmental disorder, whose causes are still poorly understood. Effective therapies to reduce all the heterogeneous symptoms of the disorder do not exists yet, but behavioural…

Neurons and Cognition · Quantitative Biology 2025-06-02 Elisa Ferrari , Alessandra Retico , Alessandro Cellerino , Davide Bacciu

Brain extraction from images is a common pre-processing step. Many approaches exist, but they are frequently only designed to perform brain extraction from images without strong pathologies. Extracting the brain from images with strong…

Computer Vision and Pattern Recognition · Computer Science 2018-05-10 Xu Han , Roland Kwitt , Stephen Aylward , Spyridon Bakas , Bjoern Menze , Alexander Asturias , Paul Vespa , John Van Horn , Marc Niethammer

Unsupervised learning of anomaly detection in high-dimensional data, such as images, is a challenging problem recently subject to intense research. Through careful modelling of the data distribution of normal samples, it is possible to…

Computer Vision and Pattern Recognition · Computer Science 2019-11-21 Amanda Berg , Jörgen Ahlberg , Michael Felsberg

Detecting novel anomalies in medical imaging is challenging due to the limited availability of labeled data for rare abnormalities, which often display high variability and subtlety. This challenge is further compounded when small abnormal…

Computer Vision and Pattern Recognition · Computer Science 2025-01-31 Jingkun Chen , Guang Yang , Xiao Zhang , Jingchao Peng , Tianlu Zhang , Jianguo Zhang , Jungong Han , Vicente Grau

Modern deep unsupervised learning methods have shown great promise for detecting diseases across a variety of medical imaging modalities. While previous generative modeling approaches successfully perform anomaly detection by learning the…

Image and Video Processing · Electrical Eng. & Systems 2021-03-26 Alex Chang , Vinith Suriyakumar , Abhishek Moturu , James Tu , Nipaporn Tewattanarat , Sayali Joshi , Andrea Doria , Anna Goldenberg

Data diversity is critical to success when training deep learning models. Medical imaging data sets are often imbalanced as pathologic findings are generally rare, which introduces significant challenges when training deep learning models.…

Computer Vision and Pattern Recognition · Computer Science 2018-09-17 Hoo-Chang Shin , Neil A Tenenholtz , Jameson K Rogers , Christopher G Schwarz , Matthew L Senjem , Jeffrey L Gunter , Katherine Andriole , Mark Michalski

Owing to success in the data-rich domain of natural images, Transformers have recently become popular in medical image segmentation. However, the pairing of Transformers with convolutional blocks in varying architectural permutations leaves…

Computer Vision and Pattern Recognition · Computer Science 2023-04-11 Saikat Roy , Gregor Koehler , Michael Baumgartner , Constantin Ulrich , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

We address the problem of anomaly detection, that is, detecting anomalous events in a video sequence. Anomaly detection methods based on convolutional neural networks (CNNs) typically leverage proxy tasks, such as reconstructing input video…

Computer Vision and Pattern Recognition · Computer Science 2020-03-31 Hyunjong Park , Jongyoun Noh , Bumsub Ham

Anomaly detection refers to the task of finding unusual instances that stand out from the normal data. In several applications, these outliers or anomalous instances are of greater interest compared to the normal ones. Specifically in the…

Image and Video Processing · Electrical Eng. & Systems 2020-01-14 Manpreet Singh Minhas , John Zelek

We consider the problem of segmenting a biomedical image into anatomical regions of interest. We specifically address the frequent scenario where we have no paired training data that contains images and their manual segmentations. Instead,…

Computer Vision and Pattern Recognition · Computer Science 2019-03-14 Adrian V. Dalca , John Guttag , Mert R. Sabuncu

Convolutional Neural Networks (CNNs) work very well for supervised learning problems when the training dataset is representative of the variations expected to be encountered at test time. In medical image segmentation, this premise is…

Image and Video Processing · Electrical Eng. & Systems 2021-01-26 Neerav Karani , Ertunc Erdil , Krishna Chaitanya , Ender Konukoglu

Unsupervised anomaly detection (UAD) in brain imaging is crucial for identifying pathologies without the need for labeled data. However, accurately localizing anomalies remains challenging due to the intricate structure of brain anatomy and…

Image and Video Processing · Electrical Eng. & Systems 2025-08-06 Farzad Beizaee , Sina Hajimiri , Ismail Ben Ayed , Gregory Lodygensky , Christian Desrosiers , Jose Dolz

Visual defect assessment is a form of anomaly detection. This is very relevant in finding faults such as cracks and markings in various surface inspection tasks like pavement and automotive parts. The task involves detection of…

Computer Vision and Pattern Recognition · Computer Science 2019-05-31 Manpreet Singh Minhas , John Zelek

Deep learning motivated by convolutional neural networks has been highly successful in a range of medical imaging problems like image classification, image segmentation, image synthesis etc. However for validation and interpretability, not…

Image and Video Processing · Electrical Eng. & Systems 2024-08-19 Abhinav Sagar

Brain disorders in the early and late life of humans potentially share pathological alterations in brain functions. However, the key evidence from neuroimaging data for pathological commonness remains unrevealed. To explore this hypothesis,…

Artificial Intelligence · Computer Science 2023-02-24 Mianxin Liu , Jingyang Zhang , Yao Wang , Yan Zhou , Fang Xie , Qihao Guo , Feng Shi , Han Zhang , Qian Wang , Dinggang Shen

Many functional and structural neuroimaging studies call for accurate morphometric segmentation of different brain structures starting from image intensity values of MRI scans. Current automatic (multi-) atlas-based segmentation strategies…

Image and Video Processing · Electrical Eng. & Systems 2019-09-27 Dennis Bontempi , Sergio Benini , Alberto Signoroni , Michele Svanera , Lars Muckli

Automating classification and segmentation process of abnormal regions in different body organs has a crucial role in most of medical imaging applications such as funduscopy, endoscopy, and dermoscopy. Detecting multiple abnormalities in…

Computer Vision and Pattern Recognition · Computer Science 2018-10-17 Mohsen Hajabdollahi , Reza Esfandiarpoor , Elyas Sabeti , Nader Karimi , Kayvan Najarian , S. M. Reza Soroushmehr , Shadrokh Samavi

Recent advancements in artificial intelligence (AI) have precipitated a paradigm shift in medical imaging, particularly revolutionizing the domain of brain imaging. This paper systematically investigates the integration of deep learning --…

Image and Video Processing · Electrical Eng. & Systems 2024-10-18 Houze Liu , Bo Zhang , Yanlin Xiang , Yuxiang Hu , Aoran Shen , Yang Lin