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Despite their widespread use in cell biology, fluorescence lifetime imaging microscopy (FLIM) data-sets are challenging to analyse, because each spatial position can contain a superposition of multiple fluorescent components. Here, we…

Biological Physics · Physics 2022-08-29 Francesco Masia , Walter Dewitte , Paola Borri , Wolfgang Langbein

Characterising the input-output photon-number distribution of an unknown optical quantum channel is an important task for many applications in quantum information processing. Ideally, this would require deterministic photon-number sources…

Quantum Physics · Physics 2021-09-14 Emilien Lavie , Ignatius William Primaatmaja , Wen Yu Kon , Chao Wang , Charles Ci Wen Lim

Flow cytometry measurements are widely used in diagnostics and medical decision making. Incomplete understanding of sources of measurement uncertainty can make it difficult to distinguish autofluorescence and background sources from signals…

Quantitative Methods · Quantitative Biology 2024-12-02 Prajakta Bedekar , Megan A. Catterton , Matthew DiSalvo , Gregory A. Cooksey , Anthony J. Kearsley , Paul N. Patrone

Scalable photonic quantum technologies require highly efficient sources of single photons on demand. Although much progress has been done in the field within the last decade, the requirements impose stringent conditions on the efficiency of…

Solid-state single-photon emitters provide a versatile platform for exploring quantum technologies such as optically connected quantum networks. A key challenge is to ensure optical coherence and spectral stability of the emitters. Here, we…

We establish a method, called pbFFS for photobleaching Fluctuation Fluorescence Spectroscopy, which aims at characterizing molecules or particles labelled with a unknown distribution or fluorophores. Using photobleaching as a control…

A complete characterization of quantum fluctuations in many-body systems is accessible through the full counting statistics. We present an exact computation of statistical properties of light in a basic model of light-matter interaction: a…

Quantum Physics · Physics 2013-02-14 Mikhail Pletyukhov , Matouš Ringel , Vladimir Gritsev

In order to tackle parameter estimation of photocounting distributions, polykays of acting intensities are proposed as a new tool for computing photon statistics. As unbiased estimators of cumulants, polykays are computationally feasible…

Methodology · Statistics 2015-08-20 Elvira Di Nardo

The rise of interest in the study of quantum emitters has recently prompted many research groups to construct their own confocal epifluorescence microscopy/spectroscopy instruments. The low light levels typically involved in quantum emitter…

Optics · Physics 2022-06-23 K. G. Scheuer , G. J. Hornig , T. R. Harrison , R. G. DeCorby

Detecting brief changes in time-series data remains a major challenge in fields where short-lived states carry meaning. In single-molecule localisation microscopy, this problem is particularly acute as fluorescent molecules used to tag…

Methodology · Statistics 2026-03-25 Emily Gribbin , Benjamin Davis , Daniel Rolfe , Hannah Mitchell

Multi-photon interference is at the heart of the recently proposed linear optical quantum computing scheme and plays an essential role in many protocols in quantum information. Indistinguishability is what leads to the effect of quantum…

Quantum Physics · Physics 2015-06-26 B. H. Liu , F. W. Sun , Y. X. Gong , Y. F. Huang , Z. Y. Ou , G. C. Guo

We consider estimation and inference in a linear model with endogenous regressors where the parameters of interest change across two samples. If the first-stage is common, we show how to use this information to obtain more efficient…

Econometrics · Economics 2024-06-26 Bertille Antoine , Otilia Boldea , Niccolo Zaccaria

This paper studies multivariate nonparametric change point localization and inference problems. The data consists of a multivariate time series with potentially short range dependence. The distribution of this data is assumed to be…

Statistics Theory · Mathematics 2023-01-30 Carlos Misael Madrid Padilla , Haotian Xu , Daren Wang , Oscar Hernan Madrid Padilla , Yi Yu

Despite the widespread usage of discrete generation Ensemble Kalman particle filtering methodology to solve nonlinear and high dimensional filtering and inverse problems, little is known about their mathematical foundations. As genetic-type…

Probability · Mathematics 2021-07-06 Pierre del Moral , Emma Horton

This article expands the framework of Bayesian inference and provides direct probabilistic methods for approaching inference tasks that are typically handled with information theory. We treat Bayesian probability updating as a random…

Data Analysis, Statistics and Probability · Physics 2023-11-20 Kevin Vanslette

Using fluorescence spectroscopy we directly measure entropy production of a single two-level system realized experimentally as an optically driven defect center in diamond. We exploit a recent suggestion to define entropy on the level of a…

Statistical Mechanics · Physics 2007-05-23 C. Tietz , S. Schuler , T. Speck , U. Seifert , J. Wrachtrup

Quantum simulation in its current state faces experimental overhead in terms of physical space and cooling. We propose boson sampling as an alternative compact synthetic platform performing at room temperature. Identifying the capability of…

Quantum Physics · Physics 2025-04-03 Anuprita V. Kulkarni , Vatsana Tiwari , Auditya Sharma , Ankur Raina

Time-resolved analysis of periodically excited luminescence decays by the phasor method in the presence of time-gating or binning is revisited. Analytical expressions for discrete configurations of square gates are derived and the locus of…

Quantitative Methods · Quantitative Biology 2024-06-12 Xavier Michalet

Multistability is a phenomenon prevalent in many natural systems. In climate, for example, it allows the possibility of irreversible consequences on planetary scale as a result of climate change. Indeed, a climate ``tipping element'' is a…

Atmospheric and Oceanic Physics · Physics 2026-04-14 George Datseris , Johannes Lohmann , Oisín Hamilton , Jacob Haqq-Misra

Understanding the temporal properties of longitudinal data is critical for identifying trends, predicting future events, and making informed decisions in any field where temporal data is analysed, including health and epidemiology, finance,…