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Systematic differences in experimental materials, methods, measurements, and data handling between labs, over time, and among personnel can sabotage experimental reproducibility. Uncovering such differences can be difficult and time…

Applications · Statistics 2018-07-18 Bert Gunter

Experimental and observational studies often lack validity due to untestable assumptions. We propose a double machine learning approach to combine experimental and observational studies, allowing practitioners to test for assumption…

Mixture models are often used to identify meaningful subpopulations (i.e., clusters) in observed data such that the subpopulations have a real-world interpretation (e.g., as cell types). However, when used for subpopulation discovery,…

Methodology · Statistics 2024-03-04 Jiawei Li , Jonathan H. Huggins

Selective Prediction is the task of rejecting inputs a model would predict incorrectly on. This involves a trade-off between input space coverage (how many data points are accepted) and model utility (how good is the performance on accepted…

This dissertation focuses on modern causal inference under uncertainty and data restrictions, with applications to neoadjuvant clinical trials, distributed data networks, and robust individualized decision making. In the first project, we…

Methodology · Statistics 2023-01-24 Xiaoqing Tan

Switchback experiments, where a firm sequentially exposes an experimental unit to random treatments, are among the most prevalent designs used in the technology sector, with applications ranging from ride-hailing platforms to online…

Methodology · Statistics 2025-09-18 Iavor Bojinov , David Simchi-Levi , Jinglong Zhao

The decision-making process in real-world implementations has been affected by a growing reliance on data-driven models. We investigated the synergetic pattern between the data-driven methods, empirical domain knowledge, and…

Computational Engineering, Finance, and Science · Computer Science 2023-09-22 Xia Chen , Ruiji Sun , Ueli Saluz , Stefano Schiavon , Philipp Geyer

We extend the model-free Data-Driven computing paradigm to solids and structures that are stochastic due to intrinsic randomness in the material behavior. The behavior of such materials is characterized by a likelihood measure instead of a…

Computational Engineering, Finance, and Science · Computer Science 2022-11-23 Erik Prume , Stefanie Reese , Michael Ortiz

Indirect experiments provide a valuable framework for estimating treatment effects in situations where conducting randomized control trials (RCTs) is impractical or unethical. Unlike RCTs, indirect experiments estimate treatment effects by…

Machine Learning · Computer Science 2023-12-06 Yash Chandak , Shiv Shankar , Vasilis Syrgkanis , Emma Brunskill

Various methods for leveraging turbulent fluctuation measurements from fusion plasma experiments are introduced, along with selected application examples. These can be categorized into spectral methods, statistical methods, and physics…

Plasma Physics · Physics 2025-10-27 Minjun J. Choi

We present a new procedure for conducting a sensitivity analysis in matched observational studies. For any candidate test statistic, the approach defines tilted modifications dependent upon the proposed strength of unmeasured confounding.…

Methodology · Statistics 2025-03-14 Colin B. Fogarty

Estimation of social influence in networks can be substantially biased in observational studies due to homophily and network correlation in exposure to exogenous events. Randomized experiments, in which the researcher intervenes in the…

Social and Information Networks · Computer Science 2017-09-28 Sean J. Taylor , Dean Eckles

Experiments on online marketplaces and social networks suffer from interference, where the outcome of a unit is impacted by the treatment status of other units. We propose a framework for modeling interference using a ubiquitous deployment…

Methodology · Statistics 2023-08-21 Ariel Boyarsky , Hongseok Namkoong , Jean Pouget-Abadie

Data-based adaptive optimization methods hold great promise for the performance optimization of uncertain, time-varying processes. However, current methods are often based on continuous perturbation which is in general undesired for…

Systems and Control · Electrical Eng. & Systems 2026-04-20 Leontine Aarnoudse , Mark Haring , Nathan van de Wouw , Alexey Pavlov

In data-driven optimization, solution feasibility is often ensured through a "safe" reformulation of the uncertain constraints, such that an obtained data-driven solution is guaranteed to be feasible for the oracle formulation with high…

Optimization and Control · Mathematics 2019-09-17 Henry Lam , Huajie Qian

There is increasing interest in combining information from experimental studies, including randomized and single-group trials, with information from external experimental or observational data sources. Such efforts are usually motivated by…

Methodology · Statistics 2026-04-23 Lawson Ung , Guanbo Wang , Sebastien Haneuse , Miguel A. Hernán , Issa J. Dahabreh

A growing number of methods aim to assess the challenging question of treatment effect variation in observational studies. This special section of "Observational Studies" reports the results of a workshop conducted at the 2018 Atlantic…

Methodology · Statistics 2019-09-17 Carlos Carvalho , Avi Feller , Jared Murray , Spencer Woody , David Yeager

Online platforms regularly conduct randomized experiments to understand how changes to the platform causally affect various outcomes of interest. However, experimentation on online platforms has been criticized for having, among other…

Machine Learning · Computer Science 2022-05-12 Smitha Milli , Luca Belli , Moritz Hardt

As artificial intelligence and machine learning tools become more accessible, and scientists face new obstacles to data collection (e.g., rising costs, declining survey response rates), researchers increasingly use predictions from…

Machine Learning · Statistics 2025-12-08 Stephen Salerno , Kentaro Hoffman , Awan Afiaz , Anna Neufeld , Tyler H. McCormick , Jeffrey T. Leek

This study introduces a data-driven, machine learning-based method to detect suitable control variables and instruments for assessing the causal effect of a treatment on an outcome in observational data. Our approach tests the joint…

Econometrics · Economics 2026-05-20 Nicolas Apfel , Julia Hatamyar , Martin Huber , Jannis Kueck