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We illustrate shape mode analysis as a simple, yet powerful technique to concisely describe complex biological shapes and their dynamics. We characterize undulatory bending waves of beating flagella and reconstruct a limit cycle of…

Quantitative Methods · Quantitative Biology 2015-06-22 Steffen Werner , Jochen C. Rink , Ingmar H. Riedel-Kruse , Benjamin M. Friedrich

One approach to understanding complex data is to study its shape through the lens of algebraic topology. While the early development of topological data analysis focused primarily on static data, in recent years, theoretical and applied…

Machine Learning · Computer Science 2021-06-29 Lu Xian , Henry Adams , Chad M. Topaz , Lori Ziegelmeier

Rapid advances in modern communication technology are enabling the accumulation of large-scale, high-resolution observational data of spatiotemporal movements of humans. Classification and prediction of human mobility based on the analysis…

Physics and Society · Physics 2016-03-16 Juyong Park , Deok-Sun Lee , Marta C. Gonzalez

The richness of many complex systems stems from the interactions among their components. The higher-order nature of these interactions, involving many units at once, and their temporal dynamics constitute crucial properties that shape the…

Physics and Society · Physics 2024-07-29 Marco Mancastroppa , Iacopo Iacopini , Giovanni Petri , Alain Barrat

We develop a language for describing the relationship among observations, mathematical models, and the underlying principles from which they are derived. Using Information Geometry, we consider geometric properties of statistical models for…

Data Analysis, Statistics and Probability · Physics 2016-07-14 Mark K. Transtrum , Gus Hart , Peng Qiu

We present a machine learning approach that leverages persistent homology to classify bacterial flagellar motors into two functional states: rotated and stalled. By embedding protein structural data into a topological framework, we extract…

Biomolecules · Quantitative Biology 2025-12-19 Zakaria Lamine , Abdelatif Hafid , Mohamed Rahouti

Graph pattern matching is often defined in terms of subgraph isomorphism, an NP-complete problem. To lower its complexity, various extensions of graph simulation have been considered instead. These extensions allow pattern matching to be…

Databases · Computer Science 2012-01-04 Shuai Ma , Yang Cao , Wenfei Fan , Jinpeng Huai , Tianyu Wo

Persistent homology is used to track the appearance and disappearance of features as we move through a nested sequence of topological spaces. Equating the nested sequence to a filtration and the appearance and disappearance of features to…

Statistics Theory · Mathematics 2020-12-17 Kathryn Garside , Aida Gjoka , Robin Henderson , Hollie Johnson , Irina Makarenko

Topological features based on persistent homology capture high-order structural information so as to augment graph neural network methods. However, computing extended persistent homology summaries remains slow for large and dense graphs and…

Machine Learning · Computer Science 2022-11-16 Zuoyu Yan , Tengfei Ma , Liangcai Gao , Zhi Tang , Yusu Wang , Chao Chen

Persistent homology is a cornerstone of topological data analysis, offering a multiscale summary of topology with robustness to nuisance transformations, such as rotations and small deformations. Persistent homology has seen broad use…

Methodology · Statistics 2025-11-19 Zitian Wu , Arkaprava Roy , Leo L. Duan

We present a topological framework for analysing neural time series that integrates Transfer Entropy (TE) with directed Persistent Homology (PH) to characterize information flow in spiking neural systems. TE quantifies directional influence…

Neurons and Cognition · Quantitative Biology 2025-08-27 Dylan Peek , Siddharth Pritam , Matthew P. Skerritt , Stephan Chalup

In this work, we develop a pipeline that associates Persistence Diagrams to digital data via the most appropriate filtration for the type of data considered. Using a grid search approach, this pipeline determines optimal representation…

Computer Vision and Pattern Recognition · Computer Science 2023-09-28 Francesco Conti , Davide Moroni , Maria Antonietta Pascali

Topology applied to real world data using persistent homology has started to find applications within machine learning, including deep learning. We present a differentiable topology layer that computes persistent homology based on level set…

Detecting small targets at range is difficult because there is not enough spatial information present in an image sub-region containing the target to use correlation-based methods to differentiate it from dynamic confusers present in the…

Computer Vision and Pattern Recognition · Computer Science 2021-02-15 Tegan Emerson , Sarah Tymochko , George Stantchev , Jason A. Edelberg , Michael Wilson , Colin C. Olson

We develop a biophysically realistic model of the nematode C. elegans that includes: (i) its muscle structure and activation, (ii) key connectomic activation circuitry, and (iii) a weighted and time-dynamic proprioception. In combination,…

Biological Physics · Physics 2018-03-02 Charles Fieseler , James Kunert-Graf , J. Nathan Kutz

This paper presents a topological analytics approach within the 5-level Cyber-Physical Systems (CPS) architecture for the Stream-of-Quality assessment in smart manufacturing. The proposed methodology not only enables real-time quality…

Machine Learning · Computer Science 2024-04-24 Jay Lee , Dai-Yan Ji , Yuan-Ming Hsu

The neural dynamics of the nematode C. elegans are experimentally low-dimensional and correspond to discrete behavioral states, where previous modeling work has found neural proxies for some of these states. Experimental results further…

Neurons and Cognition · Quantitative Biology 2015-09-04 James Kunert , Eli Shlizerman , Andrew Walker , J. Nathan Kutz

Single-parameter persistent homology, a key tool in topological data analysis, has been widely applied to data problems along with statistical techniques that quantify the significance of the results. In contrast, statistical techniques for…

Algebraic Topology · Mathematics 2020-12-14 Matthew Wright , Xiaojun Zheng

A topological shape analysis is proposed and utilized to learn concepts that reflect shape commonalities. Our approach is two-fold: i) a spatial topology analysis of point cloud segment constellations within objects. Therein constellations…

Computer Vision and Pattern Recognition · Computer Science 2018-11-22 Christian A. Mueller , Andreas Birk

This paper is a cursory study on how topological features are preserved within the internal representations of neural network layers. Using techniques from topological data analysis, namely persistent homology, the topological features of a…

Machine Learning · Computer Science 2022-08-16 Archie Shahidullah