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Quantum mechanics/molecular mechanics (QM/MM) hybrid models allow one to address chemical phenomena in complex molecular environments. Whereas this modeling approach can cope with a large system size at moderate computational costs, the…

Computational Physics · Physics 2023-01-10 Katja-Sophia Csizi , Markus Reiher

Computational studies of chemical reactions in complex environments such as proteins, nanostructures, or on surfaces require accurate and efficient atomistic models applicable to the nanometer scale. In general, an accurate parametrization…

Chemical Physics · Physics 2020-02-18 Christoph Brunken , Markus Reiher

The learning process of classical machine learning algorithms is tuned by hyperparameters that need to be customized to best learn and generalize from an input dataset. In recent years, Quantum Machine Learning (QML) has been gaining…

Hybrid manufacturing (HM) technologies combine additive and subtractive manufacturing (AM/SM) capabilities, leveraging AM's strengths in fabricating complex geometries and SM's precision and quality to produce finished parts. We present a…

Computational Geometry · Computer Science 2018-05-21 Morad Behandish , Saigopal Nelaturi , Johan de Kleer

We apply numerical optimization and linear algebra algorithms for classical computers to the problem of automatically synthesizing algorithms for quantum computers. Using our framework, we apply several common techniques from these…

Numerical Analysis · Mathematics 2025-09-16 Yuxin Huang , Benjamin E. Grossman-Ponemon , David A. B. Hyde

Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in enzyme simulation. Over ten convergence studies of QM/MM methods have revealed over the past several years that key energetic and structural properties…

Chemical Physics · Physics 2017-01-11 Maria Karelina , Heather J. Kulik

Combining quantum computers with classical compute power has become a standard means for developing algorithms that are eventually supposed to beat any purely classical alternatives. While in-principle advantages for solution quality or…

Quantum Physics · Physics 2026-01-23 Simon Thelen , Wolfgang Mauerer

Quantum software development has largely focused on algorithms, with limited attention to software architecture. As computing moves toward hybrid quantum-classical systems, this gap limits scalability, reusability, and engineering rigor.…

Software Engineering · Computer Science 2026-05-05 Arvind W. Kiwelekar , Shweta Tembe , Uzma G. A. Munde , Siddhesh Jadhav , Manjushree D. Laddha , Harsha R. Gaikwad

Automated Machine Learning (AutoML) has significantly advanced the efficiency of ML-focused software development by automating hyperparameter optimization and pipeline construction, reducing the need for manual intervention. Quantum Machine…

In the literature, there exist several quantum finite automata (QFA) models with both quantum and classical states. These models are of particular interest,as they show praiseworthy advantages over the fully quantum models in some…

Formal Languages and Automata Theory · Computer Science 2015-06-30 Lvzhou Li , Yuan Feng

An effective, accessible abstraction hierarchy has made using and programming computers possible for people across all disciplines. Establishing such a hierarchy for quantum programming is an outstanding challenge, especially due to a…

Quantum metrology plays a fundamental role in many scientific areas. However, the complexity of engineering entangled probes and the external noise raise technological barriers for realizing the expected precision of the to-be-estimated…

Quantum Physics · Physics 2021-01-21 Xiaodong Yang , Xi Chen , Jun Li , Xinhua Peng , Raymond Laflamme

In a recent study (Ref. [1]), quantum annealing was reported to exhibit a scaling advantage for approximately solving Quadratic Unconstrained Binary Optimization (QUBO). However, this claim critically depends on the choice of classical…

Quantum Physics · Physics 2025-05-29 J. Pawlowski , P. Tarasiuk , J. Tuziemski , L. Pawela , B. Gardas

In this paper, we conduct a systematic literature review of (semi-) automated approaches to Quantum Software Engineering (QSE) and Quantum Artificial Intelligence (QAI). Prior work in the literature indicated that both Software Engineering…

Software Engineering · Computer Science 2026-04-23 Nazanin Siavash , Armin Moin

Quantum feature maps are a key component of quantum machine learning, encoding classical data into quantum states to exploit the expressive power of high-dimensional Hilbert spaces. Despite their theoretical promise, designing quantum…

Quantum Physics · Physics 2026-03-25 Kenya Sakka , Kosuke Mitarai , Keisuke Fujii

We develop and analyze a framework for consistent QM/MM (quantum/classic) hybrid models of crystalline defects, which admits general atomistic interactions including traditional off-the-shell interatomic potentials as well as state of art…

Numerical Analysis · Mathematics 2021-08-05 Huajie Chen , Christoph Ortner , Yangshuai Wang

Quantum computing improves substantially on known classical algorithms for various important problems, but the nature of the relationship between quantum and classical computing is not yet fully understood. This relationship can be…

Quantum Physics · Physics 2026-02-20 Jacques Carette , Chris Heunen , Robin Kaarsgaard , Neil J. Ross , Amr Sabry

Computational prediction of enzyme mechanism and protein function requires accurate physics-based models and suitable sampling. We discuss recent advances in large-scale quantum mechanical (QM) modeling of biochemical systems that have…

Chemical Physics · Physics 2021-05-28 Vyshnavi Vennelakanti , Azadeh Nazemi , Rimsha Mehmood , Adam H. Steeves , Heather J. Kulik

We introduce a hybrid quantum-classical deep learning architecture for large language model fine-tuning. The classical portion of the architecture is a sentence transformer that is powerful enough to display significant accuracy for complex…

Quantum Physics · Physics 2025-04-14 Sang Hyub Kim , Jonathan Mei , Claudio Girotto , Masako Yamada , Martin Roetteler

In the present work, we present a hybrid quantum-classical workflow aimed at improving the accuracy of alchemical free energy (AFE) predictions by incorporating configuration interaction (CI) simulations using the book-ending correction…

Chemical Physics · Physics 2025-06-27 Milana Bazayeva , Zhen Li , Danil Kaliakin , Fangchun Liang , Akhil Shajan , Susanta Das , Kenneth M. Merz
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