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The availability of genomic data is essential to progress in biomedical research, personalized medicine, etc. However, its extreme sensitivity makes it problematic, if not outright impossible, to publish or share it. As a result, several…

Genomics · Quantitative Biology 2022-01-19 Bristena Oprisanu , Georgi Ganev , Emiliano De Cristofaro

Access to genomic data is highly regulated due to its sensitive nature. While safeguards are essential, cumbersome data access processes pose a significant barrier to the development of AI methods for genomics. Synthetic data generation can…

Cryptography and Security · Computer Science 2026-05-01 Daniil Filienko , Martine De Cock , Sikha Pentyala

We consider the challenges that arise when fitting complex ecological models to 'large' data sets. In particular, we focus on random effect models which are commonly used to describe individual heterogeneity, often present in ecological…

Methodology · Statistics 2022-05-17 Ruth King , Blanca Sarzo , Víctor Elvira

Nonlinear mixed effects models have become a standard platform for analysis when data is in the form of continuous and repeated measurements of subjects from a population of interest, while temporal profiles of subjects commonly follow a…

Methodology · Statistics 2022-03-04 Se Yoon Lee

Bayesian modelling for cost-effectiveness data has received much attention in both the health economics and the statistical literature in recent years. Cost-effectiveness data are characterised by a relatively complex structure of…

Statistics Theory · Mathematics 2013-07-22 Gianluca Baio

We provide an introductory review of Bayesian data analytical methods, with a focus on applications for linguistics, psychology, psycholinguistics, and cognitive science. The empirically oriented researcher will benefit from making Bayesian…

Applications · Statistics 2016-12-14 Bruno Nicenboim , Shravan Vasishth

The need to analyze sensitive data, such as medical records or financial data, has created a critical research challenge in recent years. In this paper, we adopt the framework of differential privacy, and explore mechanisms for generating…

Cryptography and Security · Computer Science 2024-05-09 Nikolija Bojkovic , Po-Ling Loh

Data-driven risk analysis involves the inference of probability distributions from measured or simulated data. In the case of a highly reliable system, such as the electricity grid, the amount of relevant data is often exceedingly limited,…

Methodology · Statistics 2017-07-11 Simon H. Tindemans , Goran Strbac

Empirical claims often rely on one population, design, and analysis. Many-analysts, multiverse, and robustness studies expose how results can vary across plausible analytic choices. Synthesizing these results, however, is nontrivial as all…

Methodology · Statistics 2025-11-24 František Bartoš , Suzanne Hoogeveen , Alexandra Sarafoglou , Samuel Pawel

This study examines the application of Bayesian approach in the context of clinical trials, emphasizing their increasing importance in contemporary biomedical research. While conventional frequentist approach provides a foundational basis…

Methodology · Statistics 2026-01-16 Paramahansa Pramanik , Arnab Kumar Maity , Anjan Mandal , Haley Kate Robinson

For many infectious disease outbreaks, the at-risk population changes their behavior in response to the outbreak severity, causing the transmission dynamics to change in real-time. Behavioral change is often ignored in epidemic modeling…

Methodology · Statistics 2023-10-25 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

Differential privacy is widely adopted to provide provable privacy guarantees in data analysis. We consider the problem of combining public and private data (and, more generally, data with heterogeneous privacy needs) for estimating…

Machine Learning · Computer Science 2021-11-02 Cecilia Ferrando , Jennifer Gillenwater , Alex Kulesza

Synthetic contact networks are useful for modeling epidemic spread and social transmission, but data to infer realistic contact patterns that take account of assortative connections at the geographic and economic levels is limited. We…

Social and Information Networks · Computer Science 2024-06-24 Alexander Y. Tulchinsky , Fardad Haghpanah , Alisa Hamilton , Nodar Kipshidze , Eili Y. Klein

In recent years the role of epidemic models in informing public health policies has progressively grown. Models have become increasingly realistic and more complex, requiring the use of multiple data sources to estimate all quantities of…

Methodology · Statistics 2017-06-09 Paul J Birrell , Daniela De Angelis , Anne M Presanis

Generative models have been found effective for data synthesis due to their ability to capture complex underlying data distributions. The quality of generated data from these models is commonly evaluated by visual inspection for image…

Machine Learning · Computer Science 2022-10-18 Emily Muller , Xu Zheng , Jer Hayes

Synthetic data offers a promising solution to privacy concerns in healthcare by generating useful datasets in a privacy-aware manner. However, although synthetic data is typically developed with the intention of sharing said data, ambiguous…

Statistical estimates from survey samples have traditionally been obtained via design-based estimators. In many cases, these estimators tend to work well for quantities such as population totals or means, but can fall short as sample sizes…

Methodology · Statistics 2020-09-15 Paul A. Parker , Scott H. Holan , Ryan Janicki

Count outcomes in longitudinal studies are frequent in clinical and engineering studies. In frequentist and Bayesian statistical analysis, methods such as Mixed linear models allow the variability or correlation within individuals to be…

Methodology · Statistics 2024-07-15 Alejandra Estefanía Patiño Hoyos , Johnatan Cardona Jiménez

Background: In the context of ongoing debate over data confidentiality versus shared use of research data, as raised following the new EU General Data Protection Regulation, we seek to find alternate techniques that can balance these two…

Applications · Statistics 2016-06-20 Paramita Saha-Chaudhuri , Clarice Weinberg

This paper explores the strategic use of modern synthetic data generation and advanced data perturbation techniques to enhance security, maintain analytical utility, and improve operational efficiency when managing large datasets, with a…

Cryptography and Security · Computer Science 2025-04-29 Anantha Sharma , Swetha Devabhaktuni , Eklove Mohan