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In order for machine learning to be deployed and trusted in many applications, it is crucial to be able to reliably explain why the machine learning algorithm makes certain predictions. For example, if an algorithm classifies a given…

Machine Learning · Statistics 2018-11-07 Amirata Ghorbani , Abubakar Abid , James Zou

Segmentation is the identification of anatomical regions of interest, such as organs, tissue, and lesions, serving as a fundamental task in computer-aided diagnosis in medical imaging. Although deep learning models have achieved remarkable…

Image and Video Processing · Electrical Eng. & Systems 2025-12-09 Tianyi Ren , Daniel Low , Pittra Jaengprajak , Juampablo Heras Rivera , Jacob Ruzevick , Mehmet Kurt

Cell image analysis is crucial in Alzheimer's research to detect the presence of A$\beta$ protein inhibiting cell function. Deep learning speeds up the process by making only low-level data sufficient for fruitful inspection. We first found…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Wooseok Jung

In supervised learning for medical image analysis, sample selection methodologies are fundamental to attain optimum system performance promptly and with minimal expert interactions (e.g. label querying in an active learning setup). In this…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Dwarikanath Mahapatra

Linear models are widely used in computational neuroimaging to identify biomarkers associated with brain pathologies. However, interpreting the learned weights remains challenging, as they do not always yield clinically meaningful insights.…

Machine Learning · Computer Science 2026-04-23 Sara Petiton , Antoine Grigis , Raphaël Vock , Edouard Duchesnay

Deep learning models have shown strong performance in classifying Alzheimer's disease (AD) from R2* maps, but their decision-making remains opaque, raising concerns about interpretability. Previous studies suggest biases in model decisions,…

Image and Video Processing · Electrical Eng. & Systems 2025-06-05 Christian Tinauer , Maximilian Sackl , Stefan Ropele , Christian Langkammer

Understanding the internal representations and decision mechanisms of deep neural networks remains a critical open challenge. While existing interpretability methods often identify influential input regions, they may not elucidate how a…

Machine Learning · Computer Science 2025-06-12 Farzaneh Mahdisoltani , Saeed Mahdisoltani , Roger B. Grosse , David J. Fleet

The different families of saliency methods, either based on contrastive signals, closed-form formulas mixing gradients with activations or on perturbation masks, all focus on which parts of an image are responsible for the model's…

Computer Vision and Pattern Recognition · Computer Science 2019-10-22 Sylvestre-Alvise Rebuffi , Ruth Fong , Xu Ji , Hakan Bilen , Andrea Vedaldi

Deep Neural Networks - especially Convolutional Neural Network (ConvNet) has become the state-of-the-art for image classification, pattern recognition and various computer vision tasks. ConvNet has a huge potential in medical domain for…

Computer Vision and Pattern Recognition · Computer Science 2020-09-11 Md Motiur Rahman Sagar , Martin Dyrba

We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image…

Computer Vision and Pattern Recognition · Computer Science 2018-07-09 Chengliang Yang , Anand Rangarajan , Sanjay Ranka

Recent results suggest that state-of-the-art saliency models perform far from optimal in predicting fixations. This lack in performance has been attributed to an inability to model the influence of high-level image features such as objects.…

Computer Vision and Pattern Recognition · Computer Science 2015-04-10 Matthias Kümmerer , Lucas Theis , Matthias Bethge

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

Deep learning algorithms lack human-interpretable accounts of how they transform raw visual input into a robust semantic understanding, which impedes comparisons between different architectures, training objectives, and the human brain. In…

Computer Vision and Pattern Recognition · Computer Science 2024-04-30 Gustaw Opiełka , Jessica Loke , Steven Scholte

Owing to its pristine soft-tissue contrast and high resolution, structural magnetic resonance imaging (MRI) is widely applied in neurology, making it a valuable data source for image-based machine learning (ML) and deep learning…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Merel Kuijs , Catherine R. Jutzeler , Bastian Rieck , Sarah C. Brüningk

We propose a novel perspective to understand deep neural networks in an interpretable disentanglement form. For each semantic class, we extract a class-specific functional subnetwork from the original full model, with compressed structure…

Machine Learning · Computer Science 2019-10-08 Yulong Wang , Xiaolin Hu , Hang Su

Deep learning based medical image classifiers have shown remarkable prowess in various application areas like ophthalmology, dermatology, pathology, and radiology. However, the acceptance of these Computer-Aided Diagnosis (CAD) systems in…

This paper presents a tutorial of an explainable approach using Convolutional Neural Network (CNN) and Gradient-weighted Class Activation Mapping (Grad-CAM) to classify four progressive dementia stages based on open MRI brain images. The…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Kevin Kam Fung Yuen

Deep learning (DL) models have been popular due to their ability to learn directly from the raw data in an end-to-end paradigm, alleviating the concern of a separate error-prone feature extraction phase. Recent DL-based neuroimaging studies…

Machine Learning · Computer Science 2023-07-20 Md. Mahfuzur Rahman , Vince D. Calhoun , Sergey M. Plis

The success of neural networks builds to a large extent on their ability to create internal knowledge representations from real-world high-dimensional data, such as images, sound, or text. Approaches to extract and present these…

Artificial Intelligence · Computer Science 2023-01-03 Lars Holmberg , Paul Davidsson , Per Linde

Detection of Alzheimer's Disease (AD) from neuroimaging data such as MRI through machine learning have been a subject of intense research in recent years. Recent success of deep learning in computer vision have progressed such research…

Computer Vision and Pattern Recognition · Computer Science 2017-12-01 Marcia Hon , Naimul Khan