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The random motion of molecules in living cells has consistently been reported to deviate from standard Brownian motion, a behavior coined as ``anomalous diffusion''. Fluorescence Correlation Spectroscopy (FCS) is a powerful method to…

Quantitative Methods · Quantitative Biology 2024-07-18 Nathan Quiblier , Jan-Michael Rye , Pierre Leclerc , Henri Truong , Abdelkrim Hannou , Laurent Héliot , Hugues Berry

We present a model of anomalous diffusion consisting of an ensemble of particles undergoing homogeneous Brownian motion except for confinement by randomly placed reflecting boundaries. For power-law distributed compartment sizes, we…

Soft Condensed Matter · Physics 2015-06-09 Gerald John Lapeyre

Motivated by contemporary and rich applications of anomalous diffusion processes we propose a new statistical test for fractional Brownian motion, which is one of the most popular models for anomalous diffusion systems. The test is based on…

Data Analysis, Statistics and Probability · Physics 2018-10-17 Grzegorz Sikora

Diffusion MRI measures of the human brain provide key insight into microstructural variations across individuals and into the impact of central nervous system diseases and disorders. One approach to extract information from diffusion…

Medical Physics · Physics 2022-01-19 Qianqian Yang , David C. Reutens , Viktor Vegh

The concept of random walk, in which particles or waves undergo multiple collisions with the microscopic constituents of a surrounding medium, is central to understanding diffusive transport across many research areas. However, this…

In recent years, some researchers have applied diffusion models to multivariate time series anomaly detection. The partial diffusion strategy, which depends on the diffusion steps, is commonly used for anomaly detection in these models.…

Machine Learning · Computer Science 2025-01-06 Guangqiang Wu , Fu Zhang

We theoretically study the transport properties of self-propelled particles on complex structures, such as motor proteins on filament networks. A general master equation formalism is developed to investigate the persistent motion of…

Soft Condensed Matter · Physics 2014-09-19 M. Reza Shaebani , Zeinab Sadjadi , Igor M. Sokolov , Heiko Rieger , Ludger Santen

Change point detection has become an important part of the analysis of the single-particle tracking data, as it allows one to identify moments, in which the motion patterns of observed particles undergo significant changes. The segmentation…

Quantitative Methods · Quantitative Biology 2025-06-23 Jakub Malinowski , Marcin Kostrzewa , Michał Balcerek , Weronika Tomczuk , Janusz Szwabiński

The task of detecting anomalous data patterns is as important in practical applications as challenging. In the context of spatial data, recognition of unexpected trajectories brings additional difficulties, such as high dimensionality and…

The most common way of estimating the anomalous diffusion exponent from single-particle trajectories consists in a linear fitting of the dependence of the time averaged mean square displacement on the lag time at the log-log scale. However,…

Data Analysis, Statistics and Probability · Physics 2019-01-02 Yann Lanoiselée , Denis S. Grebenkov , Grzegorz Sikora , Aleksandra Grzesiek , Agnieszka Wyłomańska

Over the last two decades, anomalous diffusion processes in which the mean squares variance grows slower or faster than that in a Gaussian process have found many applications. At a macroscopic level, these processes are adequately…

Numerical Analysis · Mathematics 2015-06-23 Bangti Jin , William Rundell

Diffusion is modeled on the recently proposed Hanoi networks by studying the mean- square displacement of random walks with time, <r^2>~t^{2/d_w}. It is found that diffusion - the quintessential mode of transport throughout Nature -…

Statistical Mechanics · Physics 2008-10-15 S. Boettcher , B. Goncalves

The purpose of this tutorial is to introduce the main concepts behind normal and anomalous diffusion. Starting from simple, but well known experiments, a series of mathematical modeling tools are introduced, and the relation between them is…

Chaotic Dynamics · Physics 2008-05-06 Loukas Vlahos , Heinz Isliker , Yannis Kominis , Kyriakos Hizanidis

In order to navigate safely and reliably in off-road and unstructured environments, robots must detect anomalies that are out-of-distribution (OOD) with respect to the training data. We present an analysis-by-synthesis approach for…

Diffusive motion is a fundamental transport mechanism in physical and biological systems, governing dynamics across a wide range of scales -- from molecular transport to animal foraging. In many complex systems, however, diffusion deviates…

Statistical Mechanics · Physics 2026-05-01 Takuma Akimoto , Jae-Hyung Jeon , Ralf Metzler , Tomoshige Miyaguchi , Takashi Uneyama , Eiji Yamamoto

We introduce a simple model of deterministic particles in weakly disordered media which exhibits a transition from normal to anomalous diffusion. The model consists of a set of non-interacting overdamped particles moving on a disordered…

Disordered Systems and Neural Networks · Physics 2017-04-26 M. Hidalgo-Soria , R. Salgado-García

3D anomaly detection plays a crucial role in monitoring parts for localized inherent defects in precision manufacturing. Embedding-based and reconstruction-based approaches are among the most popular and successful methods. However, there…

Computer Vision and Pattern Recognition · Computer Science 2024-07-16 Zheyuan Zhou , Le Wang , Naiyu Fang , Zili Wang , Lemiao Qiu , Shuyou Zhang

Diffusion and anomalous diffusion are widely observed and used to study movement across organisms, resulting in extensive use of the mean and mean-squared displacement (MSD). However, these measures - corresponding to specific displacement…

Populations and Evolution · Quantitative Biology 2025-08-14 Ohad Vilk , Motti Charter , Sivan Toledo , Eli Barkai , Ran Nathan

Modern single-particle-tracking techniques produce extensive time-series of diffusive motion in a wide variety of systems, from single-molecule motion in living-cells to movement ecology. The quest is to decipher the physical mechanisms…

Statistical Mechanics · Physics 2023-09-14 Henrik Seckler , Ralf Metzler

Recent advances in diffusion models have spurred research into their application for Reconstruction-based unsupervised anomaly detection. However, these methods may struggle with maintaining structural integrity and recovering the…

Computer Vision and Pattern Recognition · Computer Science 2025-03-27 Farzad Beizaee , Gregory A. Lodygensky , Christian Desrosiers , Jose Dolz