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Staining is essential in cell imaging and medical diagnostics but poses significant challenges, including high cost, time consumption, labor intensity, and irreversible tissue alterations. Recent advances in deep learning have enabled…

Computer Vision and Pattern Recognition · Computer Science 2025-04-15 Ziwang Xu , Lanqing Guo , Satoshi Tsutsui , Shuyan Zhang , Alex C. Kot , Bihan Wen

Staining is critical to cell imaging and medical diagnosis, which is expensive, time-consuming, labor-intensive, and causes irreversible changes to cell tissues. Recent advances in deep learning enabled digital staining via supervised model…

Image and Video Processing · Electrical Eng. & Systems 2023-03-06 Ziwang Xu , Lanqing Guo , Shuyan Zhang , Alex C. Kot , Bihan Wen

Blind image deblurring plays a very important role in many vision and multimedia applications. Most existing works tend to introduce complex priors to estimate the sharp image structures for blur kernel estimation. However, it has been…

Computer Vision and Pattern Recognition · Computer Science 2018-08-01 Risheng Liu , Yi He , Shichao Cheng , Xin Fan , Zhongxuan Luo

Recent advances in deep learning led to novel generative modeling techniques that achieve unprecedented quality in generated samples and performance in learning complex distributions in imaging data. These new models in medical image…

Computer Vision and Pattern Recognition · Computer Science 2018-06-15 Xiaoran Chen , Nick Pawlowski , Martin Rajchl , Ben Glocker , Ender Konukoglu

This work is concerned with the problem of blind source separation and its applications to imaging. We first establish a theoretical result that we stated in our previous article on imaging in diffusive environments. This result is a…

Numerical Analysis · Mathematics 2026-02-12 Randy Bartels , Olivier Pinaud

In fluorescence microscopy, spectral unmixing aims to recover individual fluorophore concentrations from spectral images that capture mixed fluorophore emissions. Since classical methods operate pixel-wise and rely on least-squares fitting,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Federico Carrara , Talley Lambert , Mehdi Seifi , Florian Jug

Blind inverse problems in imaging arise from uncertainties in the system used to collect (noisy) measurements of images. Recovering clean images from these measurements typically requires identifying the imaging system, either implicitly or…

Image and Video Processing · Electrical Eng. & Systems 2025-03-28 Brett Levac , Ajil Jalal , Kannan Ramchandran , Jonathan I. Tamir

As digital medical imaging becomes more prevalent and archives increase in size, representation learning exposes an interesting opportunity for enhanced medical decision support systems. On the other hand, medical imaging data is often…

Computer Vision and Pattern Recognition · Computer Science 2018-07-25 Eduardo Pinho , Carlos Costa

Quantitative analysis of cell structures is essential for biomedical and pharmaceutical research. The standard imaging approach relies on fluorescence microscopy, where cell structures of interest are labeled by chemical staining…

Disentangled representations can be useful in many downstream tasks, help to make deep learning models more interpretable, and allow for control over features of synthetically generated images that can be useful in training other models…

Computer Vision and Pattern Recognition · Computer Science 2021-03-22 Aadhithya Sankar , Matthias Keicher , Rami Eisawy , Abhijeet Parida , Franz Pfister , Seong Tae Kim , Nassir Navab

Two blind source separation methods (Independent Component Analysis and Non-negative Matrix Factorization), developed initially for signal processing in engineering, found recently a number of applications in analysis of large-scale data in…

Quantitative Methods · Quantitative Biology 2015-02-03 Andrei Zinovyev , Ulykbek Kairov , Tatiana Karpenyuk , Erlan Ramanculov

Blind source separation (BSS) algorithms are unsupervised methods, which are the cornerstone of hyperspectral data analysis by allowing for physically meaningful data decompositions. BSS problems being ill-posed, the resolution requires…

Signal Processing · Electrical Eng. & Systems 2022-09-28 Rémi Carloni Gertosio , Jérôme Bobin , Fabio Acero

This paper presents a generative model method for multispectral image fusion in remote sensing which is trained without supervision. This method eases the supervision of learning and it also considers a multi-objective loss function to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-09 Arian Azarang , Nasser Kehtarnavaz

As deep learning technology continues to evolve, the images yielded by generative models are becoming more and more realistic, triggering people to question the authenticity of images. Existing generated image detection methods detect…

Computer Vision and Pattern Recognition · Computer Science 2023-11-03 Xiuli Bi , Bo Liu , Fan Yang , Bin Xiao , Weisheng Li , Gao Huang , Pamela C. Cosman

Deep learning models that are trained on histopathological images obtained from a single lab and/or scanner give poor inference performance on images obtained from another scanner/lab with a different staining protocol. In recent years,…

Image and Video Processing · Electrical Eng. & Systems 2020-10-07 Harshal Nishar , Nikhil Chavanke , Nitin Singhal

Recently, generated images could reach very high quality, even human eyes could not tell them apart from real images. Although there are already some methods for detecting generated images in current forensic community, most of these…

Computer Vision and Pattern Recognition · Computer Science 2019-12-25 Xinsheng Xuan , Bo Peng , Wei Wang , Jing Dong

Deep learning has become an extremely effective tool for image classification and image restoration problems. Here, we apply deep learning to microscopy, and demonstrate how neural networks can exploit the chromatic dependence of the…

Optics · Physics 2018-07-05 Eran Hershko* , Lucien E. Weiss* , Tomer Michaeli , Yoav Shechtman

We propose a novel self-supervised image blind denoising approach in which two neural networks jointly predict the clean signal and infer the noise distribution. Assuming that the noisy observations are independent conditionally to the…

Machine Learning · Computer Science 2021-02-17 Jean Ollion , Charles Ollion , Elisabeth Gassiat , Luc Lehéricy , Sylvain Le Corff

Separating an audio scene into isolated sources is a fundamental problem in computer audition, analogous to image segmentation in visual scene analysis. Source separation systems based on deep learning are currently the most successful…

Sound · Computer Science 2018-11-07 Prem Seetharaman , Gordon Wichern , Jonathan Le Roux , Bryan Pardo

Blind source separation, i.e. extraction of independent sources from a mixture, is an important problem for both artificial and natural signal processing. Here, we address a special case of this problem when sources (but not the mixing…

Neurons and Cognition · Quantitative Biology 2017-10-20 Cengiz Pehlevan , Sreyas Mohan , Dmitri B. Chklovskii
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