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Domain adaptation (DA) aims to transfer knowledge from a label-rich source domain to a related but label-scarce target domain. The conventional DA strategy is to align the feature distributions of the two domains. Recently, increasing…

Computer Vision and Pattern Recognition · Computer Science 2022-03-08 Yixin Zhang , Junjie Li , Zilei Wang

Our world is ambiguous and this is reflected in the data we use to train our algorithms. This is particularly true when we try to model natural processes where collected data is affected by noisy measurements and differences in measurement…

Machine Learning · Computer Science 2023-07-19 Jörg K. H. Franke , Frederic Runge , Frank Hutter

Single-step retrosynthesis is the cornerstone of retrosynthesis planning, which is a crucial task for computer-aided drug discovery. The goal of single-step retrosynthesis is to identify the possible reactants that lead to the synthesis of…

Quantitative Methods · Quantitative Biology 2022-08-12 Huarui He , Jie Wang , Yunfei Liu , Feng Wu

The remarkable success of contrastive-learning-based multimodal models has been greatly driven by training on ever-larger datasets with expensive compute consumption. Sample selection as an alternative efficient paradigm plays an important…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Zihua Zhao , Feng Hong , Mengxi Chen , Pengyi Chen , Benyuan Liu , Jiangchao Yao , Ya Zhang , Yanfeng Wang

RNA-Seq and gene expression microarrays provide comprehensive profiles of gene activity, but lack of reproducibility has hindered their application. A key challenge in the data analysis is the normalization of gene expression levels, which…

Populations and Evolution · Quantitative Biology 2017-03-10 Carlos P. Roca , Susana I. L. Gomes , Mónica J. B. Amorim , Janeck J. Scott-Fordsmand

Learning a discriminative semantic space using unlabelled and noisy data remains unaddressed in a multi-label setting. We present a contrastive self-supervised learning method which is robust to data noise, grounded in the domain of…

Computer Vision and Pattern Recognition · Computer Science 2024-05-09 Mehmet Can Yavuz , Berrin Yanikoglu

Single-cell trajectory analysis aims to reconstruct the biological developmental processes of cells as they evolve over time, leveraging temporal correlations in gene expression. During cellular development, gene expression patterns…

Applications · Statistics 2026-03-30 Junhao Zhu , Kevin Zhang , Zhaolei Zhang , Dehan Kong

Deploying machine learning models in resource-constrained environments, such as edge devices or rapid prototyping scenarios, increasingly demands distillation of large datasets into significantly smaller yet informative synthetic datasets.…

Computer Vision and Pattern Recognition · Computer Science 2025-05-23 Wenmin Li , Shunsuke Sakai , Tatsuhito Hasegawa

Spatial Transcriptomics enables mapping of gene expression within its native tissue context, but current platforms measure only a limited set of genes due to experimental constraints and excessive costs. To overcome this, computational…

Genomics · Quantitative Biology 2025-11-20 Amit Kumar , Maninder Kaur , Raghvendra Mall , Sukrit Gupta

Transcriptomic analysis are characterized by being not directly quantitative and only providing relative measurements of expression levels up to an unknown individual scaling factor. This difficulty is enhanced for differential expression…

Methodology · Statistics 2021-03-24 Dorota Desaulle , Céline Hoffmann , Bernard Hainque , Yves Rozenholc

This paper presents a novel theoretical framework for understanding how diffusion models can learn disentangled representations. Within this framework, we establish identifiability conditions for general disentangled latent variable models,…

Recent empirical works have successfully used unlabeled data to learn feature representations that are broadly useful in downstream classification tasks. Several of these methods are reminiscent of the well-known word2vec embedding…

Machine Learning · Computer Science 2019-02-26 Sanjeev Arora , Hrishikesh Khandeparkar , Mikhail Khodak , Orestis Plevrakis , Nikunj Saunshi

Contrastive learning is among the most popular and powerful approaches for self-supervised representation learning, where the goal is to map semantically similar samples close together while separating dissimilar ones in the latent space.…

Machine Learning · Statistics 2025-12-03 Ali Alvandi , Mina Rezaei

Despite exciting progress in causal language models, the expressiveness of the representations is largely limited due to poor discrimination ability. To remedy this issue, we present ContraCLM, a novel contrastive learning framework at both…

How can you sample good negative examples for contrastive learning? We argue that, as with metric learning, contrastive learning of representations benefits from hard negative samples (i.e., points that are difficult to distinguish from an…

Machine Learning · Computer Science 2021-01-26 Joshua Robinson , Ching-Yao Chuang , Suvrit Sra , Stefanie Jegelka

Commit Classification (CC) is an important task in software maintenance, which helps software developers classify code changes into different types according to their nature and purpose. It allows developers to understand better how their…

Software Engineering · Computer Science 2023-08-17 Jiajun Tong , Zhixiao Wang , Xiaobin Rui

Learning a model of dynamics from high-dimensional images can be a core ingredient for success in many applications across different domains, especially in sequential decision making. However, currently prevailing methods based on…

Machine Learning · Computer Science 2019-11-05 Neha Das , Maximilian Karl , Philip Becker-Ehmck , Patrick van der Smagt

Identifying covariate shift is crucial for making machine learning systems robust in the real world and for detecting training data biases that are not reflected in test data. However, detecting covariate shift is challenging, especially…

Machine Learning · Computer Science 2021-08-20 Matthew L. Olson , Thuy-Vy Nguyen , Gaurav Dixit , Neale Ratzlaff , Weng-Keen Wong , Minsuk Kahng

Sign language recognition from sequences of monocular images or 2D poses is a challenging field, not only due to the difficulty to infer 3D information from 2D data, but also due to the temporal relationship between the sequences of…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Silvan Ferreira , Esdras Costa , Márcio Dahia , Jampierre Rocha

We propose a method for detecting differential gene expression that exploits the correlation between genes. Our proposal averages the univariate scores of each feature with the scores in correlation neighborhoods. In a number of real and…

Statistics Theory · Mathematics 2007-06-13 Robert Tibshirani , Larry Wasserman
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