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Deep learning-based computer-aided diagnosis is gradually deployed to review and analyze medical images. However, this paradigm is restricted in real-world clinical applications due to the poor robustness and generalization. The issue is…

Computer Vision and Pattern Recognition · Computer Science 2022-03-22 Yurong Chen

While deep learning models become more widespread, their ability to handle unseen data and generalize for any scenario is yet to be challenged. In medical imaging, there is a high heterogeneity of distributions among images based on the…

Image and Video Processing · Electrical Eng. & Systems 2025-05-01 Eduardo H. P. Pooch , Pedro L. Ballester , Rodrigo C. Barros

A desirable property of any deployed artificial intelligence is generalization across domains, i.e. data generation distribution under a specific acquisition condition. In medical imagining applications the most coveted property for…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 Ayan Banerjee , Komandoor Srivathsan , Sandeep K. S. Gupta

Despite their impressive performance in various surgical scene understanding tasks, deep learning-based methods are frequently hindered from deploying to real-world surgical applications for various causes. Particularly, data collection,…

Image and Video Processing · Electrical Eng. & Systems 2023-06-29 An Wang , Mobarakol Islam , Mengya Xu , Hongliang Ren

Constructing a robust model that can effectively generalize to test samples under distribution shifts remains a significant challenge in the field of medical imaging. The foundational models for vision and language, pre-trained on extensive…

Deep Learning has thrived on the emergence of biomedical big data. However, medical datasets acquired at different institutions have inherent bias caused by various confounding factors such as operation policies, machine protocols,…

Image and Video Processing · Electrical Eng. & Systems 2019-11-15 Yundong Zhang , Hang Wu , Huiye Liu , Li Tong , May D Wang

Achieving domain generalization in medical imaging poses a significant challenge, primarily due to the limited availability of publicly labeled datasets in this domain. This limitation arises from concerns related to data privacy and the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Ahmed Radwan , Islam Osman , Mohamed S. Shehata

Magnetic resonance (MR) imaging, including cardiac MR, is prone to domain shift due to variations in imaging devices and acquisition protocols. This challenge limits the deployment of trained AI models in real-world scenarios, where…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xin Ci Wong , Duygu Sarikaya , Kieran Zucker , Marc De Kamps , Nishant Ravikumar

Training robust learning algorithms across different medical imaging modalities is challenging due to the large domain gap. Unsupervised domain adaptation (UDA) mitigates this problem by using annotated images from the source domain and…

Computer Vision and Pattern Recognition · Computer Science 2025-09-29 Chen Li , Meilong Xu , Xiaoling Hu , Weimin Lyu , Chao Chen

The need to address the scarcity of task-specific annotated data has resulted in concerted efforts in recent years for specific settings such as zero-shot learning (ZSL) and domain generalization (DG), to separately address the issues of…

Computer Vision and Pattern Recognition · Computer Science 2021-07-13 Shivam Chandhok , Sanath Narayan , Hisham Cholakkal , Rao Muhammad Anwer , Vineeth N Balasubramanian , Fahad Shahbaz Khan , Ling Shao

White matter hyperintensity (WMH) is commonly found in elder individuals and appears to be associated with brain diseases. U-net is a convolutional network that has been widely used for biomedical image segmentation. Recently, U-net has…

Computer Vision and Pattern Recognition · Computer Science 2018-07-30 Yue Zhang , Wanli Chen , Yifan Chen , Xiaoying Tang

Machine learning (ML) has demonstrated significant promise in accelerating drug design. Active ML-guided optimization of therapeutic molecules typically relies on a surrogate model predicting the target property of interest. The model…

Deep learning models for medical image analysis easily suffer from distribution shifts caused by dataset artifacts bias, camera variations, differences in the imaging station, etc., leading to unreliable diagnoses in real-world clinical…

Image and Video Processing · Electrical Eng. & Systems 2024-01-09 Siyuan Yan , Chi Liu , Zhen Yu , Lie Ju , Dwarikanath Mahapatra , Brigid Betz-Stablein , Victoria Mar , Monika Janda , Peter Soyer , Zongyuan Ge

Enhancing the generalization capability of deep neural networks to unseen domains is crucial for safety-critical applications in the real world such as autonomous driving. To address this issue, this paper proposes a novel instance…

Computer Vision and Pattern Recognition · Computer Science 2021-04-01 Sungha Choi , Sanghun Jung , Huiwon Yun , Joanne Kim , Seungryong Kim , Jaegul Choo

Domain adaption (DA) and domain generalization (DG) are two closely related methods which are both concerned with the task of assigning labels to an unlabeled data set. The only dissimilarity between these approaches is that DA can access…

Computer Vision and Pattern Recognition · Computer Science 2018-12-27 Mohammad Mahfujur Rahman , Clinton Fookes , Mahsa Baktashmotlagh , Sridha Sridharan

Domain shift is a significant problem in histopathology. There can be large differences in data characteristics of whole-slide images between medical centers and scanners, making generalization of deep learning to unseen data difficult. To…

Computer Vision and Pattern Recognition · Computer Science 2019-09-27 Karin Stacke , Gabriel Eilertsen , Jonas Unger , Claes Lundström

Objective: When training machine learning models, we often assume that the training data and evaluation data are sampled from the same distribution. However, this assumption is violated when the model is evaluated on another unseen but…

Computer Vision and Pattern Recognition · Computer Science 2020-11-13 Theekshana Dissanayake , Tharindu Fernando , Simon Denman , Houman Ghaemmaghami , Sridha Sridharan , Clinton Fookes

Recent work has shown that the performance of machine learning models can vary substantially when models are evaluated on data drawn from a distribution that is close to but different from the training distribution. As a result, predicting…

Machine Learning · Computer Science 2021-08-23 Devin Guillory , Vaishaal Shankar , Sayna Ebrahimi , Trevor Darrell , Ludwig Schmidt

Most statistical learning algorithms rely on an over-simplified assumption, that is, the train and test data are independent and identically distributed. In real-world scenarios, however, it is common for models to encounter data from new…

Image and Video Processing · Electrical Eng. & Systems 2023-04-07 Zheyuan Zhang , Bin Wang , Lanhong Yao , Ugur Demir , Debesh Jha , Ismail Baris Turkbey , Boqing Gong , Ulas Bagci