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The insertion of deep learning in medical image analysis had lead to the development of state-of-the art strategies in several applications such a disease classification, as well as abnormality detection and segmentation. However, even the…

Image and Video Processing · Electrical Eng. & Systems 2022-02-24 Mauricio Orbes-Arteaga , Thomas Varsavsky , Lauge Sorensen , Mads Nielsen , Akshay Pai , Sebastien Ourselin , Marc Modat , M Jorge Cardoso

Machine learning systems generally assume that the training and testing distributions are the same. To this end, a key requirement is to develop models that can generalize to unseen distributions. Domain generalization (DG), i.e.,…

Machine Learning · Computer Science 2022-05-25 Jindong Wang , Cuiling Lan , Chang Liu , Yidong Ouyang , Tao Qin , Wang Lu , Yiqiang Chen , Wenjun Zeng , Philip S. Yu

Deep learning models perform best when tested on target (test) data domains whose distribution is similar to the set of source (train) domains. However, model generalization can be hindered when there is significant difference in the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-19 Pulkit Khandelwal , Paul Yushkevich

Image alignment across domains has recently become one of the realistic and popular topics in the research community. In this problem, a deep learning-based image alignment method is usually trained on an available largescale database.…

Computer Vision and Pattern Recognition · Computer Science 2019-06-03 Thanh-Dat Truong , Khoa Luu , Chi Nhan Duong , Ngan Le , Minh-Triet Tran

Domain generalization (DG) aims to learn predictive models that can generalize to unseen domains. Most existing DG approaches focus on learning domain-invariant representations under the assumption of conditional distribution shift (i.e.,…

Machine Learning · Computer Science 2026-02-03 Jewon Yeom , Kyubyung Chae , Hyunggyu Lim , Yoonna Oh , Dongyoon Yang , Taesup Kim

Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu

White matter hyperintensities (WMH) are radiological markers of small vessel disease and neurodegeneration, whose accurate segmentation and spatial localization are crucial for diagnosis and monitoring. While multimodal MRI offers…

Image and Video Processing · Electrical Eng. & Systems 2025-06-30 Julia Machnio , Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi

Automatic segmentation of white matter hyperintensities in magnetic resonance images is of paramount clinical and research importance. Quantification of these lesions serve as a predictor for risk of stroke, dementia and mortality. During…

Image and Video Processing · Electrical Eng. & Systems 2020-09-11 Julian Alberto Palladino , Diego Fernandez Slezak , Enzo Ferrante

In the problem of domain generalization (DG), there are labeled training data sets from several related prediction problems, and the goal is to make accurate predictions on future unlabeled data sets that are not known to the learner. This…

Machine Learning · Statistics 2021-01-08 Gilles Blanchard , Aniket Anand Deshmukh , Urun Dogan , Gyemin Lee , Clayton Scott

Domain Generalization aims to develop models that can generalize to novel and unseen data distributions. In this work, we study how model architectures and pre-training objectives impact feature richness and propose a method to effectively…

Machine Learning · Computer Science 2025-04-30 Xavier Thomas , Deepti Ghadiyaram

Medical imaging datasets usually exhibit domain shift due to the variations of scanner vendors, imaging protocols, etc. This raises the concern about the generalization capacity of machine learning models. Domain generalization (DG), which…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Chenxin Li , Qi Qi , Xinghao Ding , Yue Huang , Dong Liang , Yizhou Yu

Supervised learning results typically rely on assumptions of i.i.d. data. Unfortunately, those assumptions are commonly violated in practice. In this work, we tackle such problem by focusing on domain generalization: a formalization where…

Machine Learning · Computer Science 2024-10-30 Isabela Albuquerque , João Monteiro , Mohammad Darvishi , Tiago H. Falk , Ioannis Mitliagkas

Generalization capability to unseen domains is crucial for machine learning models when deploying to real-world conditions. We investigate the challenging problem of domain generalization, i.e., training a model on multi-domain source data…

Computer Vision and Pattern Recognition · Computer Science 2019-10-31 Qi Dou , Daniel C. Castro , Konstantinos Kamnitsas , Ben Glocker

In the generalized zero-shot learning, synthesizing unseen data with generative models has been the most popular method to address the imbalance of training data between seen and unseen classes. However, this method requires that the unseen…

Computer Vision and Pattern Recognition · Computer Science 2020-02-04 Xinsheng Wang , Shanmin Pang , Jihua Zhu

White Matter Hyperintensities (WMH) are areas of the brain that have higher intensity than other normal brain regions on Magnetic Resonance Imaging (MRI) scans. WMH is often associated with small vessel disease in the brain, making early…

Image and Video Processing · Electrical Eng. & Systems 2023-05-09 Muhammad Noor Dwi Eldianto , Muhammad Febrian Rachmadi , Wisnu Jatmiko

Standard supervised learning setting assumes that training data and test data come from the same distribution (domain). Domain generalization (DG) methods try to learn a model that when trained on data from multiple domains, would…

Computer Vision and Pattern Recognition · Computer Science 2020-08-18 Udit Maniyar , Joseph K J , Aniket Anand Deshmukh , Urun Dogan , Vineeth N Balasubramanian

Most research designing novel predictive models, or employing existing ones, assumes that training and testing data are independent and identically distributed. In practice, the data encountered at serving time often deviate from the…

Machine Learning · Computer Science 2026-03-30 Hanyu Duan , Yi Yang , Ahmed Abbasi , Kar Yan Tam

White matter hyperintensities (WMH) are key imaging markers in cognitive aging, Alzheimer's disease (AD), and related dementias. Although automated methods for WMH segmentation have advanced, most provide only global lesion load and…

Computer Vision and Pattern Recognition · Computer Science 2025-11-19 Julia Machnio , Mads Nielsen , Mostafa Mehdipour Ghazi

The domain shift between training and testing data presents a significant challenge for training generalizable deep learning models. As a consequence, the performance of models trained with the independent and identically distributed…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Aleksandr Matsun , Dana O. Mohamed , Sharon Chokuwa , Muhammad Ridzuan , Mohammad Yaqub

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi
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