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Causal inference is to estimate the causal effect in a causal relationship when intervention is applied. Precisely, in a causal model with binary interventions, i.e., control and treatment, the causal effect is simply the difference between…

Machine Learning · Computer Science 2022-07-19 Zhenyu Lu , Yurong Cheng , Mingjun Zhong , George Stoian , Ye Yuan , Guoren Wang

Observed associations in a database may be due in whole or part to variations in unrecorded (latent) variables. Identifying such variables and their causal relationships with one another is a principal goal in many scientific and practical…

Machine Learning · Computer Science 2012-12-12 Ricardo Silva , Richard Scheines , Clark Glymour , Peter L. Spirtes

Existing causal discovery methods based on combinatorial optimization or search are slow, prohibiting their application on large-scale datasets. In response, more recent methods attempt to address this limitation by formulating causal…

Machine Learning · Computer Science 2024-03-07 Victor Akinwande , J. Zico Kolter

Scaling laws have allowed Pre-trained Language Models (PLMs) into the field of causal reasoning. Causal reasoning of PLM relies solely on text-based descriptions, in contrast to causal discovery which aims to determine the causal…

The task of causal representation learning aims to uncover latent higher-level causal variables that affect lower-level observations. Identifying the true latent causal variables from observed data, while allowing instantaneous causal…

Machine Learning · Computer Science 2026-02-19 Yuhang Liu , Zhen Zhang , Dong Gong , Mingming Gong , Biwei Huang , Anton van den Hengel , Kun Zhang , Javen Qinfeng Shi

We propose a novel framework that leverages LLMs for full causal graph discovery. While previous LLM-based methods have used a pairwise query approach, this requires a quadratic number of queries which quickly becomes impractical for larger…

Machine Learning · Computer Science 2026-04-06 Thomas Jiralerspong , Xiaoyin Chen , Yash More , Vedant Shah , Yoshua Bengio

Applied researchers in biomedicine and related fields are often interested in estimating the causal effect of a treatment or intervention. Although randomized clinical trials are considered the gold standard for establishing causal effects,…

Learning efficiently a causal model of the environment is a key challenge of model-based RL agents operating in POMDPs. We consider here a scenario where the learning agent has the ability to collect online experiences through direct…

Machine Learning · Computer Science 2021-06-29 Maxime Gasse , Damien Grasset , Guillaume Gaudron , Pierre-Yves Oudeyer

In nonlinear latent variable models or dynamic models, if we consider the latent variables as confounders (common causes), the noise dependencies imply further relations between the observed variables. Such models are then closely related…

Machine Learning · Computer Science 2012-03-19 Kun Zhang , Bernhard Schoelkopf , Dominik Janzing

Large Language Models (LLMs) have been used as experts to infer causal graphs, often by repeatedly applying a pairwise prompt that asks about the causal relationship of each variable pair. However, such experts, including human domain…

Artificial Intelligence · Computer Science 2025-04-09 Aniket Vashishtha , Abbavaram Gowtham Reddy , Abhinav Kumar , Saketh Bachu , Vineeth N Balasubramanian , Amit Sharma

Multi-omics studies often rely on pathway enrichment to interpret heterogeneous molecular changes, but pathway enrichment (PE)-based workflows inherit structural limitations of pathway resources, including curation lag, functional…

Computation and Language · Computer Science 2026-01-01 Sibo Wei , Peng Chen , Lifeng Dong , Yin Luo , Lei Wang , Peng Zhang , Wenpeng Lu , Jianbin Guo , Hongjun Yang , Dajun Zeng

Data fusion, the process of combining observational and experimental data, can enable the identification of causal effects that would otherwise remain non-identifiable. Although identification algorithms have been developed for specific…

Machine Learning · Statistics 2025-12-22 Otto Tabell , Santtu Tikka , Juha Karvanen

We define a Causal Decision Problem as a Decision Problem where the available actions, the family of uncertain events and the set of outcomes are related through the variables of a Causal Graphical Model $\mathcal{G}$. A solution criteria…

Artificial Intelligence · Computer Science 2019-02-07 M. Gonzalez-Soto , L. E. Sucar , H. J. Escalante

Explanatory studies, such as randomized controlled trials, are targeted to extract the true causal effect of interventions on outcomes and are by design adjusted for covariates through randomization. On the contrary, observational studies…

Methodology · Statistics 2022-05-02 Riddhiman Adib , Sheikh Iqbal Ahamed , Mohammad Adibuzzaman

The mainstream of research in genetics, epigenetics and imaging data analysis focuses on statistical association or exploring statistical dependence between variables. Despite their significant progresses in genetic research, understanding…

Genomics · Quantitative Biology 2018-05-14 Rong Jiao , Nan Lin , Zixin Hu , David A Bennett , Li Jin , Momiao Xiong

Causal discovery estimates the underlying physical process that generates the observed data: does X cause Y or does Y cause X? Current methodologies use structural conditions to turn the causal query into a statistical query, when only…

Machine Learning · Statistics 2020-08-14 Martin Jørgensen , Søren Hauberg

We consider the problem of learning causal models from observational data generated by linear non-Gaussian acyclic causal models with latent variables. Without considering the effect of latent variables, one usually infers wrong causal…

Machine Learning · Computer Science 2019-08-13 Saber Salehkaleybar , AmirEmad Ghassami , Negar Kiyavash , Kun Zhang

Causal discovery is becoming a key part in medical AI research. These methods can enhance healthcare by identifying causal links between biomarkers, demographics, treatments and outcomes. They can aid medical professionals in choosing more…

Nonlinear causal discovery from observational data imposes strict identifiability assumptions on the formulation of structural equations utilized in the data generating process. The evaluation of structure learning methods under assumption…

Machine Learning · Statistics 2024-12-17 Georg Velev , Stefan Lessmann

We consider learning a causal ordering of variables in a linear non-Gaussian acyclic model called LiNGAM. Several existing methods have been shown to consistently estimate a causal ordering assuming that all the model assumptions are…

Machine Learning · Statistics 2013-07-30 Tatsuya Tashiro , Shohei Shimizu , Aapo Hyvarinen , Takashi Washio