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This Thesis delves into the development and implementation of quantum algorithms using the digital-analog quantum computing (DAQC) paradigm. It provides a comparative analysis of the performance of DAQC versus traditional digital…

Quantum Physics · Physics 2024-01-22 Ana Martin

Variational quantum algorithms provide a direct, physics-based approach to protein structure prediction, but their accuracy is limited by the coarse resolution of the energy landscapes generated on current noisy devices. We propose a hybrid…

Emerging Technologies · Computer Science 2025-10-09 Yuqi Zhang , Yuxin Yang , Feixiong Chen , Cheng-Chang Lu , Nima Saeidi , Samuel L. Volchenboum , Junhan Zhao , Siwei Chen , Weiwen Jiang , Qiang Guan

Parameterized quantum circuits (PQCs) play an essential role in the application of variational quantum algorithms (VQAs) in noisy intermediate-scale quantum (NISQ) devices. The PQCs are a leading candidate to achieve a quantum advantage in…

Quantum Physics · Physics 2025-10-10 Joona V. Pankkonen , Matti Raasakka , Andrea Marchesin , Ilkka Tittonen

Demonstrating the practical utility of Noisy Intermediate-Scale Quantum (NISQ) hardware for recurrent tasks in Computer-Aided Drug Discovery is of paramount importance. We tackle this challenge by performing three-dimensional protein…

Quantum Physics · Physics 2025-12-12 Daniele Loco , Kisa Barkemeyer , Andre R. R. Carvalho , Jean-Philip Piquemal

Noisy Intermediate-Scale Quantum (NISQ) algorithms require novel paradigms of error mitigation. To obtain noise-robust quantum computers, each logical qubit is equipped with hundreds or thousands of physical qubits. However, it is not…

In this paper, we introduce an efficient algorithm for the quantum amplitude estimation task which works in noisy intermediate-scale quantum(NISQ) devices. The quantum amplitude estimation is an important problem which has various…

Quantum Physics · Physics 2021-11-29 Kouhei Nakaji

Quantum Machine Learning (QML) represents a promising frontier at the intersection of quantum computing and artificial intelligence, aiming to leverage quantum computational advantages to enhance data-driven tasks. This review explores the…

Machine Learning · Computer Science 2025-07-14 Samarth Kashyap , Rohit K Ramakrishnan , Kumari Jyoti , Apoorva D Patel

Quantum chemistry is among the most promising applications of quantum computing, offering the potential to solve complex electronic structure problems more efficiently than classical approaches. A critical component of any quantum algorithm…

Quantum Physics · Physics 2025-06-02 Smik Patel , Praveen Jayakumar , Tzu-Ching Yen , Artur F. Izmaylov

Hybrid quantum-classical algorithms are central to much of the current research in quantum computing, particularly when considering the noisy intermediate-scale quantum (NISQ) era, with a number of experimental demonstrations having already…

Quantum Physics · Physics 2022-07-15 Adam Callison , Nicholas Chancellor

Quantum simulation is one of the key applications of quantum computing, which accelerates research and development in the fields such as chemistry and material science. The recent development of noisy intermediate-scale quantum (NISQ)…

The realization of quantum advantage with noisy-intermediate-scale quantum (NISQ) machines has become one of the major challenges in computational sciences. Maintaining coherence of a physical system with more than ten qubits is a critical…

The Variational Quantum Eigensolver (VQE) algorithm has been developed to target near term Noisy Intermediate Scale Quantum (NISQ) computers as a method to find the eigenvalues of Hamiltonians. Unlike fully quantum algorithms such as…

Quantum Physics · Physics 2026-02-13 Taylor Harville , Rishu Khurana , Vitor F. Grizzi , Cong Liu

Given the impending timeline of developing good-quality quantum processing units, it is time to rethink the approach to advance quantum computing research. Rather than waiting for quantum hardware technologies to mature, we need to start…

Quantum Physics · Physics 2024-05-12 Koen Bertels , Emma Turki , Tamara Sarac , Aritra Sarkar , Imran Ashraf

Solving electronic structure problems is considered one of the most promising applications of quantum computing. However, due to limitations imposed by the coherence time of qubits in the Noisy Intermediate Scale Quantum (NISQ) era or the…

Quantum Physics · Physics 2025-03-20 Shuo Sun , Chandan Kumar , Kevin Shen , Elvira Shishenina , Christian B. Mendl

Noisy intermediate-scale quantum (NISQ) hardware is almost universally incompatible with full-scale optimization problems of practical importance which can have many variables and unwieldy objective functions. As a consequence, there is a…

Quantum Physics · Physics 2022-05-10 Sean J. Weinberg , Fabio Sanches , Takanori Ide , Kazumitzu Kamiya , Randall Correll

Quantum-classical hybrid algorithms are emerging as promising candidates for near-term practical applications of quantum information processors in a wide variety of fields ranging from chemistry to physics and materials science. We report…

Noisy intermediate-scale quantum (NISQ) devices are valuable platforms for testing the tenets of quantum computing, but these devices are susceptible to errors arising from de-coherence, leakage, cross-talk and other sources of noise. This…

Quantum Physics · Physics 2024-07-03 Samudra Dasgupta , Travis S. Humble

The molecular energies of chemical systems have been successfully calculated on quantum computers, however, more attention has been paid to the dynamic process of chemical reactions in practical application, especially in catalyst design,…

Quantum Physics · Physics 2023-03-28 Qiankun Gong , Qingmin Man , Ye Li , Menghan Dou , Qingchun Wang , Yu-Chun Wu , Guo-Ping Guo

The variational quantum eigensolver (VQE) is a hybrid quantum-classical algorithm designed for current and near-term quantum devices. Despite its initial success, there is a lack of understanding involving several of its key aspects. There…

Quantum Physics · Physics 2023-03-22 Manpreet Singh Jattana , Fengping Jin , Hans De Raedt , Kristel Michielsen

The ground state of second-quantized quantum chemistry Hamiltonians is key to determining molecular properties. Neural quantum states (NQS) offer flexible and expressive wavefunction ansatze for this task but face two main challenges:…

Chemical Physics · Physics 2025-06-18 An-Jun Liu , Bryan K. Clark
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