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We consider the following basic inference problem: there is an unknown high-dimensional vector $w \in \mathbb{R}^n$, and an algorithm is given access to labeled pairs $(x,y)$ where $x \in \mathbb{R}^n$ is a measurement and $y = w \cdot x +…

Computational Complexity · Computer Science 2019-11-05 Xue Chen , Anindya De , Rocco A. Servedio

DNA as a data storage medium has several advantages, including far greater data density compared to electronic media. We propose that schemes for data storage in the DNA of living organisms may benefit from studying the reconstruction…

Information Theory · Computer Science 2019-09-10 Yonatan Yehezkeally , Moshe Schwartz

This paper introduces a new family of reconstruction codes which is motivated by applications in DNA data storage and sequencing. In such applications, DNA strands are sequenced by reading some subset of their substrings. While previous…

Information Theory · Computer Science 2022-05-10 Yonatan Yehezkeally , Daniella Bar-Lev , Sagi Marcovich , Eitan Yaakobi

How efficiently can we find an unknown graph using distance queries between its vertices? We assume that the unknown graph is connected, unweighted, and has bounded degree. The goal is to find every edge in the graph. This problem admits a…

Data Structures and Algorithms · Computer Science 2021-12-14 Claire Mathieu , Hang Zhou

Characterizing the differential excision of mRNA is critical for understanding the functional complexity of a cell or tissue, from normal developmental processes to disease pathogenesis. Most transcript reconstruction methods infer…

Quantitative Methods · Quantitative Biology 2022-11-15 Marjan Hosseini , Devin McConnell , Derek Aguiar

The problem of reconstructing a sequence of independent and identically distributed symbols from a set of equal size, consecutive, fragments, as well as a dependent reference sequence, is considered. First, in the regime in which the…

Information Theory · Computer Science 2023-07-20 Nir Weinberger , Ilan Shomorony

Reconstructing a finite set of curves from an unordered set of sample points is a well studied topic. There has been less effort that considers how much better the reconstruction can be if tangential information is given as well. We show…

Computational Geometry · Computer Science 2009-03-11 Leslie Greengard , Chris Stucchio

Tandem duplication in DNA is the process of inserting a copy of a segment of DNA adjacent to the original position. Motivated by applications that store data in living organisms, Jain {\em et al.} (2016) proposed the study of codes that…

Combinatorics · Mathematics 2017-11-20 Yeow Meng Chee , Johan Chrisnata , Han Mao Kiah , Tuan Thanh Nguyen

The tree edit distance is a natural dissimilarity measure between rooted ordered trees whose nodes are labeled over an alphabet $\Sigma$. It is defined as the minimum number of node edits (insertions, deletions, and relabelings) required to…

Data Structures and Algorithms · Computer Science 2025-07-04 Tomasz Kociumaka , Ali Shahali

For any $T \geq 1$, there are constants $R=R(T) \geq 1$ and $\zeta=\zeta(T)>0$ and a randomized algorithm that takes as input an integer $n$ and two strings $x,y$ of length at most $n$, and runs in time $O(n^{1+\frac{1}{T}})$ and outputs an…

Data Structures and Algorithms · Computer Science 2019-05-10 Michal Koucký , Michael E. Saks

In phase retrieval we want to recover an unknown signal $\boldsymbol x\in\mathbb C^d$ from $n$ quadratic measurements of the form $y_i = |\langle{\boldsymbol a}_i,{\boldsymbol x}\rangle|^2+w_i$ where $\boldsymbol a_i\in \mathbb C^d$ are…

Machine Learning · Statistics 2018-07-27 Marco Mondelli , Andrea Montanari

The edit distance $ed(X,Y)$ of two strings $X,Y\in \Sigma^*$ is the minimum number of character edits (insertions, deletions, and substitutions) needed to transform $X$ into $Y$. Its weighted counterpart $ed^w(X,Y)$ minimizes the total cost…

Data Structures and Algorithms · Computer Science 2025-07-04 Itai Boneh , Egor Gorbachev , Tomasz Kociumaka

We study the problem of approximating edit distance in sublinear time. This is formalized as the $(k,k^c)$-Gap Edit Distance problem, where the input is a pair of strings $X,Y$ and parameters $k,c>1$, and the goal is to return YES if…

Data Structures and Algorithms · Computer Science 2022-10-04 Elazar Goldenberg , Tomasz Kociumaka , Robert Krauthgamer , Barna Saha

The edit distance of two strings is the minimum number of insertions, deletions, and substitutions of characters needed to transform one string into the other. The textbook dynamic-programming algorithm computes the edit distance of two…

Data Structures and Algorithms · Computer Science 2023-10-25 Alejandro Cassis , Tomasz Kociumaka , Philip Wellnitz

In this paper, we study the Random Access Problem in DNA storage, which addresses the challenge of retrieving a specific information strand from a DNA-based storage system. In this framework, the data is represented by $k$ information…

Information Theory · Computer Science 2025-08-26 Avital Boruchovsky , Ohad Elishco , Ryan Gabrys , Anina Gruica , Itzhak Tamo , Eitan Yaakobi

The text-to-pattern Hamming distances problem asks to compute the Hamming distances between a given pattern of length $m$ and all length-$m$ substrings of a given text of length $n\ge m$. We focus on the $k$-mismatch version of the problem,…

Data Structures and Algorithms · Computer Science 2022-03-30 Raphaël Clifford , Paweł Gawrychowski , Tomasz Kociumaka , Daniel P. Martin , Przemysław Uznański

Given a pair of strings, the problems of computing their Longest Common Subsequence and Edit Distance have been extensively studied for decades. For exact algorithms, LCS and Edit Distance (with character insertions and deletions) are…

Data Structures and Algorithms · Computer Science 2019-04-12 Aviad Rubinstein , Zhao Song

This paper deals with the problem of reconstructing a band-limited signal when a finite subset of its samples and of its derivative are missing. The technique used, due to P.J.S.G. Ferreira, is based on the use of a particular frame for…

Functional Analysis · Mathematics 2010-09-13 Paola Brianzi , Vincenza Del Prete

Given two strings of length $n$ over alphabet $\Sigma$, and an upper bound $k$ on their edit distance, the algorithm of Myers (Algorithmica'86) and Landau and Vishkin (JCSS'88) computes the unweighted string edit distance in…

Data Structures and Algorithms · Computer Science 2023-02-09 Debarati Das , Jacob Gilbert , MohammadTaghi Hajiaghayi , Tomasz Kociumaka , Barna Saha

Graphs are a powerful tool for analyzing large data sets, but many real-world phenomena involve interactions that go beyond the simple pairwise relationships captured by a graph. In this paper we introduce and study a simple combinatorial…

Data Structures and Algorithms · Computer Science 2025-11-25 Elise Tate , Joshua A. Grochow
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