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Subtle changes in white matter (WM) microstructure have been associated with normal aging and neurodegeneration. To study these associations in more detail, it is highly important that the WM tracts can be accurately and reproducibly…
Alzheimer's disease (AD) is a progressive and incurable neurodegenerative disease which destroys brain cells and causes loss to patient's memory. An early detection can prevent the patient from further damage of the brain cells and hence…
Brain pathologies can vary greatly in size and shape, ranging from few pixels (i.e. MS lesions) to large, space-occupying tumors. Recently proposed Autoencoder-based methods for unsupervised anomaly segmentation in brain MRI have shown…
Reliable detection of the prodromal stages of Alzheimer's disease (AD) remains difficult even today because, unlike other neurocognitive impairments, there is no definitive diagnosis of AD in vivo. In this context, existing research has…
Alzheimer's Disease (AD) is a severe brain disorder, destroying memories and brain functions. AD causes chronically, progressively, and irreversibly cognitive declination and brain damages. The reliable and effective evaluation of early…
The most recent fast and accurate image segmentation methods are built upon fully convolutional deep neural networks. In this paper, we propose new deep learning strategies for DenseNets to improve segmenting images with subtle differences…
Identifying objective neuroimaging biomarkers to forecast Alzheimer's disease (AD) progression is crucial for timely intervention. However, this task remains challenging due to the complex dysfunctions in the spatio-temporal characteristics…
This paper considers the problem of brain disease classification based on connectome data. A connectome is a network representation of a human brain. The typical connectome classification problem is very challenging because of the small…
Machine learning approaches for Alzheimer's disease (AD) diagnosis face a fundamental challenges. Clinical assessments are expensive and invasive, leaving ground truth labels available for only a fraction of neuroimaging datasets. We…
Individual's general well-being is greatly impacted by mental health conditions including depression and Post-Traumatic Stress Disorder (PTSD), underscoring the importance of early detection and precise diagnosis in order to facilitate…
INTRODUCTION: Advanced machine learning methods might help to identify dementia risk from neuroimaging, but their accuracy to date is unclear. METHODS: We systematically reviewed the literature, 2006 to late 2016, for machine learning…
Disease modifying therapies for Alzheimer's disease demand precise timing decisions, yet current predictive models require longitudinal observations and provide no uncertainty quantification, rendering them impractical at the critical first…
A large number of surface-based analyses on brain imaging data adopt some specific brain atlases to better assess structural and functional changes in one or more brain regions. In these analyses, it is necessary to obtain an anatomically…
Accurate and efficient classification of Alzheimer's disease (AD) severity from brain magnetic resonance imaging (MRI) remains a critical challenge, particularly when limited data and model interpretability are of concern. In this work, we…
Segmentation of thigh tissues (muscle, fat, inter-muscular adipose tissue (IMAT), bone, and bone marrow) from magnetic resonance imaging (MRI) scans is useful for clinical and research investigations in various conditions such as aging,…
Segmentation of brain structures on MRI is the primary step for further quantitative analysis of brain diseases. Manual segmentation is still considered the gold standard in terms of accuracy; however, such data is extremely time-consuming…
Blood vessels of the brain provide the human brain with the required nutrients and oxygen. As a vulnerable part of the cerebral blood supply, pathology of small vessels can cause serious problems such as Cerebral Small Vessel Diseases…
Brains with complex distortion of cerebral anatomy present several challenges to automatic tissue segmentation methods of T1-weighted MR images. First, the very high variability in the morphology of the tissues can be incompatible with the…
Multiple Sclerosis (MS) is a type of brain disease which causes visual, sensory, and motor problems for people with a detrimental effect on the functioning of the nervous system. In order to diagnose MS, multiple screening methods have been…
Parkinsons Disease (PD) is a progressive neurological disorder that primarily affects motor functions and can lead to mild cognitive impairment (MCI) and dementia in its advanced stages. With approximately 10 million people diagnosed…