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Coarse-grained models are a core computational tool in theoretical chemistry and biophysics. A judicious choice of a coarse-grained model can yield physical insight by isolating the essential degrees of freedom that dictate the…

Statistical Mechanics · Physics 2023-04-12 Shriram Chennakesavalu , David J. Toomer , Grant M. Rotskoff

Coupled length and time scales determine the dynamic behavior of polymers and underlie their unique viscoelastic properties. To resolve the long-time dynamics it is imperative to determine which time and length scales must be correctly…

Soft Condensed Matter · Physics 2016-02-16 K. Michael Salerno , Anupriya Agrawal , Dvora Perahia , Gary S. Grest

A dynamical atomistic chain to simulate mechanical properties of a one-dimensional material with zero temperature may be modelled by the molecular dynamics (MD) model. Because the number of particles (atoms) is huge for a MD model, in…

Numerical Analysis · Mathematics 2019-02-22 Mingjie Liao , Ping Lin

Compared to top-down coarse-grained (CG) models, bottom-up approaches are capable of offering higher structural fidelity. This fidelity results from the tight link to a higher-resolution reference, making the CG model chemically specific.…

Chemical Physics · Physics 2022-09-21 Kiran H. Kanekal , Joseph F. Rudzinski , Tristan Bereau

A generalized understanding of protein dynamics is an unsolved scientific problem, the solution of which is critical to the interpretation of the structure-function relationships that govern essential biological processes. Here, we approach…

Colloidal gels are a prototypical example of a heterogeneous network solid whose complex properties are governed by thermally-activated dynamics. In this Letter we experimentally establish the connection between the intermittent dynamics of…

Soft Condensed Matter · Physics 2017-05-10 Jan Maarten van Doorn , Jochem Bronkhorst , Ruben Higler , Ties van de Laar , Joris Sprakel

A hallmark of meso-scale interfacial fluids is the multi-faceted, scale-dependent interfacial energy, which often manifests different characteristics across the molecular and continuum scale. The multi-scale nature imposes a challenge to…

Computational Physics · Physics 2023-02-22 Pei Ge , Linfeng Zhang , Huan Lei

Machine-learned (ML) coarse-grained (CG) models are a promising tool for significantly enhancing the efficiency of molecular simulations by systematically removing degrees of freedom while retaining fidelity to the underlying fine-grained…

Chemical Physics · Physics 2026-02-27 Patrick G. Sahrmann , Benjamin T. Nebgen , Kipton Barros , Brenden W. Hamilton

A general scheme, which includes constructions of coarse-grained (CG) models, weighted ensemble dynamics (WED) simulations and cluster analyses (CA) of stable states, is presented to detect dynamical and thermodynamical properties in…

Soft Condensed Matter · Physics 2008-12-04 Xin Zhou

Conjugated organic molecules play a central role in a wide range of optoelectronic devices, including organic light-emitting diodes, organic field-effect transistors, and organic solar cells. A major bottleneck in the computational design…

We investigate the structural and topological properties of hydrophobic homopolymer chains in aqueous solutions using molecular dynamics simulations and circuit topology (CT) analysis. By combining geometric observables, such as radius of…

Soft Condensed Matter · Physics 2026-01-01 Junichi Komatsu , Kenichiro Koga , Jonas Berx

Dynamical polydispersity in single-particle properties, for example a fluctuating particle size, shape, charge density, etc., is intrinsic to responsive colloids (RCs), such as biomacromolecules or microgels, but is typically not resolved…

Soft Condensed Matter · Physics 2021-05-26 Upayan Baul , Joachim Dzubiella

Machine learning has become a central technique for modeling in science and engineering, either complementing or as surrogates to physics-based models. Significant efforts have recently been devoted to models capable of predicting field…

Statistical Mechanics · Physics 2024-12-06 Brian H. Lee , Kat Nykiel , Ava E. Hallberg , Brice Rider , Alejandro Strachan

Describing the interactions of water molecules is one of the most common, yet critical, tasks in molecular dynamics simulations. Because of its unique properties, hundreds of attempts have been made to construct an ideal interaction…

Chemical Physics · Physics 2025-06-23 Bálint Soczó , Ildikó Pethes

We investigate the occurrence of waterlike thermodynamic and dynamic anomalous behavior in a one dimensional lattice gas model. The system thermodynamics is obtained using the transfer matrix technique and anomalies on density and…

Soft Condensed Matter · Physics 2015-03-11 Marco Aurélio A. Barbosa , Fernando Vito Barbosa , Fernando Albuquerque de Oliveira

In fluids under temperature gradients, long-range correlations (LRCs) emerge generically, leading to enhanced density fluctuations. This phenomenon, characterized by the $\boldsymbol{q}^{-4}$ divergence in the static structure factor (where…

Statistical Mechanics · Physics 2025-03-18 Hiroyoshi Nakano , Kazuma Yokota

The authors present a study of the non equilibrium statistical properties of a one dimensional hard-rod fluid dissipating energy via inelastic collisions and subject to the action of a Gaussian heat bath, simulating an external driving…

Materials Science · Physics 2009-11-13 Umberto Marini-Bettolo-Marconi , Pedro Tarazona , Fabio Cecconi

Quantitative models of associative learning that explain the behavior of real animals with high precision have turned out very difficult to construct. We do this in the context of the dynamics of the thermal preference of C. elegans. For…

Biological Physics · Physics 2022-06-02 Ahmed Roman , Konstantine Palanski , Ilya Nemenman , William S Ryu

We propose a dynamic coarse-graining (CG) scheme for mapping heterogeneous polymer fluids onto extremely CG models in a dynamically consistent manner. The idea is to use as target function for the mapping a wave-vector dependent mobility…

Soft Condensed Matter · Physics 2021-05-26 Bing Li , Kostas Daoulas , Friederike Schmid

Transfer Learning (TL) is currently the most effective approach for modeling building thermal dynamics when only limited data are available. TL uses a pretrained model that is fine-tuned to a specific target building. However, it remains…

Systems and Control · Electrical Eng. & Systems 2025-12-12 Fabian Raisch , Max Langtry , Felix Koch , Ruchi Choudhary , Christoph Goebel , Benjamin Tischler