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Biomolecular condensates are complex droplets comprising diverse molecules that interact using various mechanisms. Condensation is often driven by short-ranged attraction, but net charges can also mediate long-ranged repulsion. Using…

Soft Condensed Matter · Physics 2025-01-23 Chengjie Luo , Nathaniel Hess , Dilimulati Aierken , Yicheng Qiang , Jerelle A. Joseph , David Zwicker

Biomolecular condensates are small droplets forming spontaneously in biological cells via phase separation. They play a role in many cellular processes, but it is unclear how cells control them. Cellular regulation often relies on…

Soft Condensed Matter · Physics 2024-03-15 Jan Kirschbaum , David Zwicker

Some members of the vegetal kingdom can achieve surprisingly fast movements making use of a clever combination of evaporation, elasticity and cavitation. In this process, enthalpic energy is transformed into elastic energy and suddenly…

Fluid Dynamics · Physics 2019-11-27 M. A. Bruning , M. Costalonga , J. H. Snoeijer , A. Marin

Droplet formation has emerged as an essential concept for the spatiotemporal organisation of biomolecules in cells. However, classical descriptions of droplet dynamics based on passive liquid-liquid phase separation cannot capture the…

Biological Physics · Physics 2025-11-14 David Zwicker , Oliver W. Paulin , Cathelijne ter Burg

Phase separation within polymer networks plays a central role in shaping the structure and mechanics of both synthetic materials and living cells, including the formation of biomolecular condensates within cytoskeletal networks. Previous…

Soft Condensed Matter · Physics 2025-12-01 Takahiro Yokoyama , Yicheng Qiang , David Zwicker , Arash Nikoubashman

Biological cells and synthetic analogues use liquid-liquid phase separation to dynamically compartmentalize their environment for various applications. In many cases, multiple droplets need to coexist, and their size needs to be controlled,…

Soft Condensed Matter · Physics 2025-12-03 Guido Kusters , David Zwicker

Controlling the size of droplets, for example in biological cells, is challenging because large droplets typically outcompete smaller droplets due to surface tension. This coarsening is generally accelerated by hydrodynamic effects, but…

Soft Condensed Matter · Physics 2026-02-05 Stefan Köstler , Yicheng Qiang , Guido Kusters , David Zwicker

Droplets are essential for spatially controlling biomolecules in cells. To work properly, cells need to control the emergence and morphology of droplets. On the one hand, driven chemical reactions can affect droplets profoundly. For…

Soft Condensed Matter · Physics 2024-03-14 Noah Ziethen , David Zwicker

Living and engineered systems rely on the stable coexistence of two interspersed liquid phases. Yet surface tension drives their complete separation. Here we show that stable droplets of uniform and tuneable size can be produced through…

Living cells are characterized by the micrometric confinement of various macromolecules at high concentrations. Using droplets containing binary polymer blends as artificial cells, we previously showed that cell-sized confinement causes…

Living cells use phase separation and concentration gradients to organize chemical compartments in space. Here, we present a theoretical study of droplet dynamics in gradient systems. We derive the corresponding growth law of droplets and…

Biological Physics · Physics 2017-05-19 Christoph A. Weber , Chiu Fan Lee , Frank Jülicher

Phase separation in passive systems leads to uncontrolled droplet growth, limiting structural control in soft materials and cells. We identify a generic mechanism to arrest coarsening based on chemical interconversion between molecular…

Soft Condensed Matter · Physics 2026-03-19 Florian Raßhofer , Erwin Frey

We examine the fundamental fluid dynamical mechanisms dictating the generation of bioaerosols in the human trachea during intense respiratory events such as coughing and sneezing, with an emphasis on the role played by the mucosalivary…

Fluid Dynamics · Physics 2025-05-26 Mogeng Li , Youssef Saade , Stéphane Zaleski , Uddalok Sen , Pallav Kant , Detlef Lohse

The formation of (bio)molecular condensates via liquid-liquid phase separation in cells has received increasing attention, as these coacervates play important functional and regulatory roles within biological systems. However, the majority…

Soft Condensed Matter · Physics 2022-11-24 Arash Nikoubashman , Miho Yanagisawa

Active droplets are artificial microswimmers built from a liquid dispersion by microfluidic tools and showing self-propelled motion. These systems hold particular interest for mimicking biological phenomena, such as some aspects of cell…

Soft Condensed Matter · Physics 2023-06-14 Adriano Tiribocchi , Mihir Durve , Marco Lauricella , Andrea Montessori , Davide Marenduzzo , Sauro Succi

Liquid-liquid phase separation is an important mechanism for compartmentalizing the cell's cytoplasm, allowing the dynamic organization of the components necessary for survival. However, it is not clear how phase separation is affected by…

Soft Condensed Matter · Physics 2022-01-31 Estefania Vidal-Henriquez , David Zwicker

The formation of condensates is now considered as a major organization principle of eukaryotic cells. Several studies have recently shown that the properties of these condensates are affected by enzymatic reactions. We propose here a simple…

Soft Condensed Matter · Physics 2024-11-19 Jacques Fries , Javier Diaz , Marie Jardat , Ignacio Pagonabarraga , Pierre Illien , Vincent Dahirel

The influence of surface constraints on the self-assembly of liquid droplets is investigated. A semi-quantitative explanation for large scale pattern formation consisting of small scale closely arranged droplets inside the large scale…

Soft Condensed Matter · Physics 2019-06-28 K Nilavarasi , S G Ramkumar , V Madhurima

Driven chemical reactions can control the macroscopic properties of droplets, like their size. Such active droplets are critical in structuring the interior of biological cells. Cells also need to control where and when droplets appear, so…

Soft Condensed Matter · Physics 2024-03-15 Noah Ziethen , Jan Kirschbaum , David Zwicker

We investigate the drying dynamics of porous media with two pore diameters separated by several orders of magnitude. Nanometer-sized pores at the edge of our samples prevent air entry, while drying proceeds by heterogeneous nucleation of…

Soft Condensed Matter · Physics 2014-10-01 Olivier Vincent , David A. Sessoms , Erik J. Huber , Jules Guioth , Abraham D. Stroock
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