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DNA storage systems face significant challenges, including insertion, deletion, and substitution (IDS) errors. Therefore, designing effective synchronization codes, i.e., codes capable of correcting IDS errors, is essential for DNA storage…

Information Theory · Computer Science 2025-05-23 Javad Haghighat , Tolga M. Duman

DNA is a promising medium for digital information storage for its exceptional density and durability. While prior studies advanced coding theory, workflow design, and simulation tools, challenges such as synthesis costs, sequencing errors,…

Emerging Technologies · Computer Science 2025-10-06 Rakesh Thakur , Lavanya Singh , Yashika , Manomay Bundawala , Aruna Kumar

Although the expenses associated with DNA sequencing have been rapidly decreasing, the current cost of sequencing information stands at roughly $120/GB, which is dramatically more expensive than reading from existing archival storage…

Discrete Mathematics · Computer Science 2023-11-30 Daniella Bar-Lev , Omer Sabary , Ryan Gabrys , Eitan Yaakobi

We study the theoretical performance of a combined approach to demodulation and decoding of binary continuous-phase modulated signals under repetition-like codes. This technique is motivated by a need to transmit packetized or framed data…

Information Theory · Computer Science 2014-04-28 Gaurav Thakur

The goal of a denoising algorithm is to reconstruct a signal from its noise-corrupted observations. Perfect reconstruction is seldom possible and performance is measured under a given fidelity criterion. In a recent work, the authors…

Information Theory · Computer Science 2009-11-11 George Gemelos , Styrmir Sigurjonsson , Tsachy Weissman

Labeling of DNA molecules is a fundamental technique for DNA visualization and analysis. This process was mathematically modeled in [1], where the received sequence indicates the positions of the used labels. In this work, we develop error…

Information Theory · Computer Science 2025-11-04 Dganit Hanania , Eitan Yaakobi

With the emergence of new storage and communication methods, the insertion, deletion, and substitution (IDS) channel has attracted considerable attention. However, many topics on the IDS channel and the associated Levenshtein distance…

Information Theory · Computer Science 2025-12-15 Alan J. X. Guo , Sihan Sun , Xiang Wei , Mengyi Wei , Xin Chen

Synthetic DNA approaches 227.5 exabytes per gram of storage density with stability over millennial timescales. Realising this capacity requires error-correction codes that recover data from substantial synthesis and sequencing errors.…

Information Theory · Computer Science 2026-04-23 James L. Banal

Recently deep neural networks have been successfully used for various classification tasks, especially for problems with massive perfectly labeled training data. However, it is often costly to have large-scale credible labels in real-world…

Machine Learning · Computer Science 2019-01-15 Mingxiao An , Yongzhou Chen , Qi Liu , Chuanren Liu , Guangyi Lv , Fangzhao Wu , Jianhui Ma

We propose a new coding scheme, called the delayed coding (DC) scheme, for channels with insertion, deletion, and substitution (IDS) errors. The proposed scheme employs delayed encoding and non-iterative detection and decoding strategies to…

Information Theory · Computer Science 2022-05-25 Ryo Shibata , Hiroyuki Yashima

After being trained, classifiers must often operate on data that has been corrupted by noise. In this paper, we consider the impact of such noise on the features of binary classifiers. Inspired by tools for classifier robustness, we…

Machine Learning · Statistics 2017-03-09 Frederic Sala , Shahroze Kabir , Guy Van den Broeck , Lara Dolecek

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Shaping codes are used to generate code sequences in which the symbols obey a prescribed probability distribution. They arise naturally in the context of source coding for noiseless channels with unequal symbol costs. Recently, shaping…

Information Theory · Computer Science 2022-05-10 Yi Liu , Yonglong Li , Pengfei Huang , Paul H. Siegel

We introduce a novel method to analyse complete genomes and recognise some distinctive features by means of an adaptive compression algorithm, which is not DNA-oriented. We study the Information Content as a function of the number of…

Genomics · Quantitative Biology 2007-05-23 Giulia Menconi

Not only is network coding essential to achieve the capacity of a single-session multicast network, it can also help to improve the throughput of wireless networks with multiple unicast sessions when overheard information is available. Most…

Information Theory · Computer Science 2010-03-24 Haishi Ning , Cong Ling , Kin K. Leung

The DNA storage channel is considered, in which the $M$ Deoxyribonucleic acid (DNA) molecules comprising each codeword are stored without order, sampled $N$ times with replacement, and then sequenced over a discrete memoryless channel. For…

Information Theory · Computer Science 2022-02-15 Nir Weinberger , Neri Merhav

Noise in data appears to be inevitable in most real-world machine learning applications and would cause severe overfitting problems. Not only can data features contain noise, but labels are also prone to be noisy due to human input. In this…

Machine Learning · Computer Science 2025-05-09 Weipeng Huang , Qin Li , Yang Xiao , Cheng Qiao , Tie Cai , Junwei Liang , Neil J. Hurley , Guangyuan Piao

Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Curtis G Callan , William Bialek

Motivated by DNA based data storage system, we investigate the errors that occur when synthesizing DNA strands in parallel, where each strand is appended one nucleotide at a time by the machine according to a template supersequence. If…

Information Theory · Computer Science 2024-05-06 Ziyang Lu , Han Mao Kiah , Yiwei Zhang , Robert N. Grass , Eitan Yaakobi

We study data structures in the presence of adversarial noise. We want to encode a given object in a succinct data structure that enables us to efficiently answer specific queries about the object, even if the data structure has been…

Data Structures and Algorithms · Computer Science 2008-12-01 Ronald de Wolf