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Deep neural networks have incredible capacity and expressibility, and can seemingly memorize any training set. This introduces a problem when training in the presence of noisy labels, as the noisy examples cannot be distinguished from clean…

Machine Learning · Computer Science 2022-10-04 Daniel Shwartz , Uri Stern , Daphna Weinshall

Synchronization errors, such as insertions and deletions, present a fundamental challenge in DNA-based data storage systems, arising from both synthesis and sequencing noise. These channels are often modeled as…

Information Theory · Computer Science 2025-06-23 Ziv Aharoni , Henry D. Pfister

The process of DNA-based data storage (DNA storage for short) can be mathematically modelled as a communication channel, termed DNA storage channel, whose inputs and outputs are sets of unordered sequences. To design error correcting codes…

Information Theory · Computer Science 2020-06-11 Wentu Song , Kui Cai , Kees A. Schouhamer Immink

DNA is a leading candidate as the next archival storage media due to its density, durability and sustainability. To read (and write) data DNA storage exploits technology that has been developed over decades to sequence naturally occurring…

Emerging Technologies · Computer Science 2022-05-12 Jasmine Quah , Omer Sella , Thomas Heinis

DNA, with remarkable properties of high density, durability, and replicability, is one of the most appealing storage media. Emerging DNA storage technologies use composite DNA letters, where information is represented by probability…

Information Theory · Computer Science 2025-03-26 Wenkai Zhang , Zhiying Wang

To make DNA a suitable medium for archival data storage, it is essential to consider the decay process of the strands observed in DNA storage systems. This paper studies the decay process as a probabilistic noisy torn paper channel (TPC),…

Information Theory · Computer Science 2026-01-19 Frederik Walter , Maria Abu-Sini , Nils Weinhardt , Antonia Wachter-Zeh

In this paper, we study achievable rates of concatenated coding schemes over a deoxyribonucleic acid (DNA) storage channel. Our channel model incorporates the main features of DNA-based data storage. First, information is stored on many,…

Information Theory · Computer Science 2020-05-04 Andreas Lenz , Lorenz Welter , Sven Puchinger

We study the following semi-deterministic setting of the joint source-channel coding problem: a deterministic source sequence (a.k.a. individual sequence) is transmitted via a memoryless channel, using delay-limited encoder and decoder,…

Information Theory · Computer Science 2021-09-29 Neri Merhav

Due to their sequential nature, traditional DNA synthesis methods are expensive in terms of time and resources. They also fabricate multiple copies of the same strand, introducing redundancy. This redundancy can be leveraged to enhance the…

Information Theory · Computer Science 2025-10-29 Frederik Walter , Yonatan Yehezkeally

Stochastic encoders for channel coding and lossy source coding are introduced with a rate close to the fundamental limits, where the only restriction is that the channel input alphabet and the reproduction alphabet of the lossy source code…

Information Theory · Computer Science 2016-11-15 Jun Muramatsu

This paper proves the separation between source-network coding and channel coding in networks of noisy, discrete, memoryless channels. We show that the set of achievable distortion matrices in delivering a family of dependent sources across…

Information Theory · Computer Science 2016-11-17 Shirin Jalali , Michelle Effros

Nanopore sequencing is an emerging DNA sequencing technology that has been proposed for use in DNA storage systems. We propose the noisy nanopore channel model for nanopore sequencing. This model captures duplications, inter-symbol…

Information Theory · Computer Science 2022-05-10 Brendon McBain , Emanuele Viterbo , James Saunderson

We consider a molecular channel, in which messages are encoded to the frequency of objects (or concentration of molecules) in a pool, and whose output during reading time is a noisy version of the input frequencies, as obtained by sampling…

Information Theory · Computer Science 2024-05-14 Yuval Gerzon , Ilan Shomorony , Nir Weinberger

The design of codes for communicating reliably over a statistically well defined channel is an important endeavor involving deep mathematical research and wide-ranging practical applications. In this work, we present the first family of…

Machine Learning · Computer Science 2018-07-03 Hyeji Kim , Yihan Jiang , Sreeram Kannan , Sewoong Oh , Pramod Viswanath

We consider the situation in which a transmitter attempts to communicate reliably over a discrete memoryless channel while simultaneously ensuring covertness (low probability of detection) with respect to a warden, who observes the signals…

Information Theory · Computer Science 2016-11-18 Matthieu R. Bloch

We study the channel coding problem when errors and uncertainty occur in the encoding process. For simplicity we assume the channel between the encoder and the decoder is perfect. Focusing on linear block codes, we model the encoding…

Information Theory · Computer Science 2013-05-17 Jad Hachem , I-Hsiang Wang , Christina Fragouli , Suhas Diggavi

In shotgun sequencing, the input string (typically, a long DNA sequence composed of nucleotide bases) is sequenced as multiple overlapping fragments of much shorter lengths (called \textit{reads}). Modelling the shotgun sequencing pipeline…

Information Theory · Computer Science 2024-05-14 Hrishi Narayanan , Prasad Krishnan , Nita Parekh

Owing to its longevity and enormous information density, DNA, the molecule encoding biological information, has emerged as a promising archival storage medium. However, due to technological constraints, data can only be written onto many…

Emerging Technologies · Computer Science 2018-03-12 Reinhard Heckel , Gediminas Mikutis , Robert N. Grass

Encoding information in combinations of pre-synthesised deoxyribonucleic acid (DNA) strands (referred to as motifs) is an interesting approach to DNA storage that could potentially circumvent the prohibitive costs of…

Information Theory · Computer Science 2024-12-05 Roman Sokolovskii , Parv Agarwal , Luis Alberto Croquevielle , Zijian Zhou , Thomas Heinis

We provide an overview of current approaches to DNA-based storage system design and accompanying synthesis, sequencing and editing methods. We also introduce and analyze a suite of new constrained coding schemes for both archival and random…

Emerging Technologies · Computer Science 2015-07-08 S. M. Hossein Tabatabaei Yazdi , Han Mao Kiah , Eva Ruiz Garcia , Jian Ma , Huimin Zhao , Olgica Milenkovic