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Plasmonic nanopores hold a significant promise for molecular sequencing, but their sensitivity and temporal resolution are constrained by limited signal strength and rapid translocation of molecules through the pore. Here we report an…

Optics · Physics 2026-05-12 Nageswar Reddy Sanamreddy , Paolo Vavassori

Solid-state nanopores offer a powerful platform for nanoscale analysis of individual analytes, including biomolecules and functionalized nanoparticles, by confining them within a precisely defined sensing region. However, their inherently…

The manipulation of microparticles using optical forces has led to many applications in the life and physical sciences. To extend optical trapping towards the nano-regime, in this work we demonstrate trapping of single nanoparticles in…

Biomolecules exhibit dynamic conformations critical to their functions, yet observing these processes at the single-molecule level under native conditions remains a formidable challenge. While surface immobilization has been widely used to…

Instrumentation and Detectors · Physics 2025-12-22 Funing Liu , Qitao Hu , Anton Sabantsev , Giovanni Di Muccio , Shuangshuang Zeng , Mauro Chinappi , Sebastian Deindl , Zhen Zhang

Here, we propose an easy and robust strategy for the versatile preparation of hybrid plasmonic nanopores by means of controlled deposition of single flakes of MoS2 directly on top of metallic holes. The device is realized on silicon nitride…

Optical manipulation has attracted remarkable interest owing to its versatile and non-invasive nature. However, conventional optical trapping remains inefficient for the nanoscopic world. The emergence of plasmonics in recent years has…

Optics · Physics 2021-02-03 Domna G. Kotsifaki , Viet Giang Truong , Sile Nic Chormaic

Plasmonic antennas, leveraging localized surface plasmon resonance (LSPR), hold significant promise for efficiently trapping nanoscale particles at low power levels. However, their effectiveness is hindered by photothermal effects in…

Optics · Physics 2023-08-08 Theodore Anyika , Ikjun Hong , Justus Ndukaife

The efficiency of nanopore-based biosequencing techniques requires fast anionic polymer capture by like-charged pores followed by a prolonged translocation process. We show that this condition can be achieved by setting a pressure-solvation…

Soft Condensed Matter · Physics 2018-06-20 Sahin Buyukdagli

In solid-state nanopores, achieving reliable control over pore aperture opening and closing (gating) remains a major challenge. Gating can be driven by the applied voltage involving electrically tunable chemical reactions, achieved by…

Solid-state nanopore gating inspired by biological ion channels is gaining increasing traction due to a large range of applications in biosensing and drug delivery. Integration of stimuli-responsive molecules such as…

In recent years, plasmonic optical tweezers have been used to trap nanoparticles and study interactions with their environment. An unavoidable challenge is the plasmonic heating due to resonant excitation and the resulting temperature rise…

Plasmonics represents a unique approach to confine and enhance electromagnetic radiation well below the diffraction limit, bringing a huge potential for novel applications, for instance in energy harvesting, optoelectronics, and nanoscale…

Heterogeneous nanoscale particles released by cells known as extracellular vesicles (EVs) are actively investigated for early disease detection1, monitoring2, and advanced therapeutics3. Due to their extremely small size, the stable…

Optics · Physics 2024-01-26 Chuchuan Hong , Justus C. Ndukaife

Electronic excitations in metallic nanoparticles in the optical regime that have been of great importance in surface enhanced spectroscopy and emerging applications of molecular plasmonics, due to control and confinement of electromagnetic…

Mesoscale and Nanoscale Physics · Physics 2015-10-28 Marouane Salhi , Ali Passian , George Siopsis

Nanopores spanning synthetic membranes have been used as key components in proof-of-principle nanofluidic applications, particularly those involving manipulation of biomolecules or sequencing of DNA. The only practical way of manipulating…

Mesoscale and Nanoscale Physics · Physics 2016-09-21 Tom Chou

Recent advances in nanotechnologies have prompted the need for tools to accurately and non invasively manipulate individual nanoobjects. Among the possible strategies, optical forces have been widely used to enable nano optical tweezers…

Recent years have seen a surge of interest in nanopores because such structures show a strong potential for characterizing nanoparticles, proteins, DNA, and even single molecules. These systems have been extensively studied in experiment as…

Soft Condensed Matter · Physics 2016-06-22 Georg Rempfer , Sascha Ehrhardt , Christian Holm , Joost de Graaf

Metal nanoantennas enable the manipulation of light emission and detection at the single photon level by confining light into very small volumes. Emitters coupled to these plasmonic structures are thus ideal candidates for usage in quantum…

Optics · Physics 2020-08-11 Nathan Kimmitt , Esther A. Wertz

Electrokinetic force has been the major choice for driving the translocation of molecules through a nanopore. However, the use of this approach is limited by an uncontrollable translocation speed, resulting in non-uniform conductance…

Applied Physics · Physics 2024-04-22 Jianxin Yang , Tianle Pan , Zhenming Xie , Wu Yuan , Ho-Pui Ho

Controlling the transport, trapping, and filtering of nanoparticles is important for many applications. By virtue of their weak response to gravity and their thermal motion, various physical mechanisms can be exploited for such operations…

Materials Science · Physics 2016-11-03 Rasoul Alaee , Muamer Kadic , Carsten Rockstuhl , Ali Passian
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