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The de novo design of drug molecules is recognized as a time-consuming and costly process, and computational approaches have been applied in each stage of the drug discovery pipeline. Variational autoencoder is one of the computer-aided…

Quantum Physics · Physics 2021-12-24 Junde Li , Swaroop Ghosh

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based autoencoders have shown great potential in detecting anomalies in medical images. However, especially…

Image and Video Processing · Electrical Eng. & Systems 2020-01-03 David Zimmerer , Simon Kohl , Jens Petersen , Fabian Isensee , Klaus Maier-Hein

A new approach for blind channel equalization and decoding, variational inference, and variational autoencoders (VAEs) in particular, is introduced. We first consider the reconstruction of uncoded data symbols transmitted over a noisy…

Machine Learning · Computer Science 2020-04-14 Avi Caciularu , David Burshtein

Combining neuroimaging datasets from multiple sites and scanners can help increase statistical power and thus provide greater insight into subtle neuroanatomical effects. However, site-specific effects pose a challenge by potentially…

Computer Vision and Pattern Recognition · Computer Science 2024-08-29 Ayodeji Ijishakin , Ana Lawry Aguila , Elizabeth Levitis , Ahmed Abdulaal , Andre Altmann , James Cole

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Jacob Beattie , Tanya Berger-Wolf , Yu Su

When applying the foreground removal methods to uncover the faint cosmological signal from the epoch of reionization (EoR), the foreground spectra are assumed to be smooth. However, this assumption can be seriously violated in practice…

Instrumentation and Methods for Astrophysics · Physics 2019-03-15 Weitian Li , Haiguang Xu , Zhixian Ma , Ruimin Zhu , Dan Hu , Zhenghao Zhu , Junhua Gu , Chenxi Shan , Jie Zhu , Xiang-Ping Wu

Variational Autoencoders (VAEs) are a popular generative model, but one in which conditional inference can be challenging. If the decomposition into query and evidence variables is fixed, conditional VAEs provide an attractive solution. To…

Machine Learning · Statistics 2018-10-05 Ga Wu , Justin Domke , Scott Sanner

Unsupervised learning can leverage large-scale data sources without the need for annotations. In this context, deep learning-based auto encoders have shown great potential in detecting anomalies in medical images. However, state-of-the-art…

Machine Learning · Computer Science 2018-12-17 David Zimmerer , Simon A. A. Kohl , Jens Petersen , Fabian Isensee , Klaus H. Maier-Hein

Early identification of Adverse Drug Events (ADE) is critical for taking prompt actions while introducing new drugs into the market. These ADEs information are available through various unstructured data sources like clinical study reports,…

Computation and Language · Computer Science 2024-12-23 Vinayak Arannil , Tomal Deb , Atanu Roy

Predicting cellular responses to various perturbations is a critical focus in drug discovery and personalized therapeutics, with deep learning models playing a significant role in this endeavor. Single-cell datasets contain technical…

Machine Learning · Computer Science 2024-09-11 Seungheun Baek , Soyon Park , Yan Ting Chok , Junhyun Lee , Jueon Park , Mogan Gim , Jaewoo Kang

Dense passage retrieval aims to retrieve the relevant passages of a query from a large corpus based on dense representations (i.e., vectors) of the query and the passages. Recent studies have explored improving pre-trained language models…

Computation and Language · Computer Science 2022-12-05 Xing Wu , Guangyuan Ma , Meng Lin , Zijia Lin , Zhongyuan Wang , Songlin Hu

Chinese characters carry a wealth of morphological and semantic information; therefore, the semantic enhancement of the morphology of Chinese characters has drawn significant attention. The previous methods were intended to directly extract…

Computer Vision and Pattern Recognition · Computer Science 2022-07-19 Zongze Chen , Wenxia Yang , Xin Li

In this paper, we present a general framework to scale graph autoencoders (AE) and graph variational autoencoders (VAE). This framework leverages graph degeneracy concepts to train models only from a dense subset of nodes instead of using…

Machine Learning · Computer Science 2022-06-22 Guillaume Salha , Romain Hennequin , Viet Anh Tran , Michalis Vazirgiannis

Classic variational autoencoders are used to learn complex data distributions, that are built on standard function approximators. Especially, VAE has shown promise on a lot of complex task. In this paper, a new autoencoder model -…

Computer Vision and Pattern Recognition · Computer Science 2020-01-13 Qiuyu Zhu , Ruixin Zhang

As an important problem in causal inference, we discuss the estimation of treatment effects (TEs). Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational autoencoder (VAE), motivated by the…

Machine Learning · Statistics 2022-04-22 Pengzhou Wu , Kenji Fukumizu

High-dimensional clinical data have become invaluable resources for genetic studies, due to their accessibility in biobank-scale datasets and the development of high performance modeling techniques especially using deep learning. Recent…

Machine Learning · Computer Science 2023-07-19 Taedong Yun

This paper aims to provide an approach for automatic coding of physician-patient communication transcripts to improve patient-centered communication (PCC). PCC is a central part of high-quality health care. To improve PCC, dialogues between…

Computation and Language · Computer Science 2021-09-23 Gilchan Park , Julia Taylor Rayz , Cleveland G. Shields

Regularized autoencoders learn the latent codes, a structure with the regularization under the distribution, which enables them the capability to infer the latent codes given observations and generate new samples given the codes. However,…

Machine Learning · Computer Science 2019-02-18 Wenju Xu , Shawn Keshmiri , Guanghui Wang

Inspired by recent advances in diffusion models, which are reminiscent of denoising autoencoders, we investigate whether they can acquire discriminative representations for classification via generative pre-training. This paper shows that…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Weilai Xiang , Hongyu Yang , Di Huang , Yunhong Wang

Self-supervised learning has attracted increasing attention as it learns data-driven representation from data without annotations. Vision transformer-based autoencoder (ViT-AE) by He et al. (2021) is a recent self-supervised learning…

Computer Vision and Pattern Recognition · Computer Science 2023-05-17 Chinmay Prabhakar , Hongwei Bran Li , Jiancheng Yang , Suprosana Shit , Benedikt Wiestler , Bjoern Menze
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