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Recent work has demonstrated that deep neural networks are vulnerable to adversarial examples---inputs that are almost indistinguishable from natural data and yet classified incorrectly by the network. In fact, some of the latest findings…

Machine Learning · Statistics 2019-09-06 Aleksander Madry , Aleksandar Makelov , Ludwig Schmidt , Dimitris Tsipras , Adrian Vladu

The remarkable success of pretrained language models has motivated the study of what kinds of knowledge these models learn during pretraining. Reformulating tasks as fill-in-the-blanks problems (e.g., cloze tests) is a natural approach for…

Computation and Language · Computer Science 2020-11-10 Taylor Shin , Yasaman Razeghi , Robert L. Logan , Eric Wallace , Sameer Singh

Antibodies are vital proteins offering robust protection for the human body from pathogens. The development of general protein and antibody-specific pre-trained language models both facilitate antibody prediction tasks. However, there have…

Computation and Language · Computer Science 2023-03-03 Danqing Wang , Fei Ye , Hao Zhou

Geometric deep learning has recently achieved great success in non-Euclidean domains, and learning on 3D structures of large biomolecules is emerging as a distinct research area. However, its efficacy is largely constrained due to the…

Machine Learning · Computer Science 2023-10-31 Fang Wu , Lirong Wu , Dragomir Radev , Jinbo Xu , Stan Z. Li

Protein Language Models (PLMs), pre-trained on extensive evolutionary data from natural proteins, have emerged as indispensable tools for protein design. While powerful, PLMs often struggle to produce proteins with precisely specified…

Biomolecules · Quantitative Biology 2025-09-15 Long-Kai Huang , Rongyi Zhu , Bing He , Jianhua Yao

Large Language Models (LLMs) have transformed the natural language processing landscape and brought to life diverse applications. Pretraining on vast web-scale data has laid the foundation for these models, yet the research community is now…

This paper demonstrates that language models are strong structure-based protein designers. We present LM-Design, a generic approach to reprogramming sequence-based protein language models (pLMs), that have learned massive sequential…

Machine Learning · Computer Science 2023-02-10 Zaixiang Zheng , Yifan Deng , Dongyu Xue , Yi Zhou , Fei YE , Quanquan Gu

In this paper, we study a new learning paradigm for Neural Machine Translation (NMT). Instead of maximizing the likelihood of the human translation as in previous works, we minimize the distinction between human translation and the…

Computation and Language · Computer Science 2018-10-02 Lijun Wu , Yingce Xia , Li Zhao , Fei Tian , Tao Qin , Jianhuang Lai , Tie-Yan Liu

Masked language modeling (MLM) has been widely used for pre-training effective bidirectional representations, but incurs substantial training costs. In this paper, we propose a novel concept-based curriculum masking (CCM) method to…

Computation and Language · Computer Science 2022-12-16 Mingyu Lee , Jun-Hyung Park , Junho Kim , Kang-Min Kim , SangKeun Lee

In this work, we provide a survey of active learning (AL) for its applications in natural language processing (NLP). In addition to a fine-grained categorization of query strategies, we also investigate several other important aspects of…

Computation and Language · Computer Science 2023-02-06 Zhisong Zhang , Emma Strubell , Eduard Hovy

Distributed representations of words which map each word to a continuous vector have proven useful in capturing important linguistic information not only in a single language but also across different languages. Current unsupervised…

Computation and Language · Computer Science 2019-04-23 Haozhou Wang , James Henderson , Paola Merlo

Natural language processing (NLP) enables the understanding and generation of meaningful human language, typically using a pre-trained complex architecture on a large dataset to learn the language and next fine-tune its weights to implement…

Computation and Language · Computer Science 2025-09-04 Yarden Tzach , Ronit D. Gross , Ella Koresh , Shalom Rosner , Or Shpringer , Tal Halevi , Ido Kanter

Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

Artificial Intelligence · Computer Science 2025-04-21 Yijia Xiao , Edward Sun , Yiqiao Jin , Qifan Wang , Wei Wang

The field of chemistry and Artificial Intelligence (AI) intersection is an area of active research that aims to accelerate scientific discovery. The integration of large language models (LLMs) with scientific modalities has shown…

Computation and Language · Computer Science 2024-07-16 Dimitris Gkoumas

The surge of state-of-the-art Transformer-based models has undoubtedly pushed the limits of NLP model performance, excelling in a variety of tasks. We cast the spotlight on the underexplored task of Natural Language Inference (NLI), since…

Computation and Language · Computer Science 2025-08-04 Alexandros Koulakos , Maria Lymperaiou , Giorgos Filandrianos , Giorgos Stamou

Deep learning-based Natural Language Processing methods, especially transformers, have achieved impressive performance in the last few years. Applying those state-of-the-art NLP methods to legal activities to automate or simplify some…

Computation and Language · Computer Science 2021-09-16 Saibo Geng , Rémi Lebret , Karl Aberer

Computational protein-protein interaction (PPI) prediction techniques can contribute greatly in reducing time, cost and false-positive interactions compared to experimental approaches. Sequence is one of the key and primary information of…

Machine Learning · Computer Science 2022-03-29 Soumyadeep Debnath , Ayatullah Faruk Mollah

Pre-trained language models learn informative word representations on a large-scale text corpus through self-supervised learning, which has achieved promising performance in fields of natural language processing (NLP) after fine-tuning.…

Computation and Language · Computer Science 2023-10-31 Jian Yang , Xinyu Hu , Gang Xiao , Yulong Shen

Natural Language Processing (NLP) is widely used in fields like machine translation and sentiment analysis. However, traditional NLP models struggle with accuracy and efficiency. This paper introduces Deep Convolutional Neural Networks…

Computation and Language · Computer Science 2024-12-23 Chang Weng , Scott Rood , Mehdi Ali Ramezani , Amir Aslani , Reza Zarrab , Wang Zwuo , Sanjeev Salimans , Tim Satheesh

In the past few years, the emergence of pre-training models has brought uni-modal fields such as computer vision (CV) and natural language processing (NLP) to a new era. Substantial works have shown they are beneficial for downstream…

Computer Vision and Pattern Recognition · Computer Science 2024-04-19 Feilong Chen , Duzhen Zhang , Minglun Han , Xiuyi Chen , Jing Shi , Shuang Xu , Bo Xu