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Protein language models are trained primarily with masked language modeling (MLM), which predicts amino-acid identities at masked positions. We ask whether latent-space prediction can complement these token-level objectives under matched…

Machine Learning · Computer Science 2026-05-11 Dan Ofer , Dafna Shahaf , Michal Linial

In recent years, protein-text models have gained significant attention for their potential in protein generation and understanding. Current approaches focus on integrating protein-related knowledge into large language models through…

Computation and Language · Computer Science 2025-11-11 Juntong Wu , Zijing Liu , He Cao , Hao Li , Bin Feng , Zishan Shu , Ke Yu , Li Yuan , Yu Li

Given the widespread use of deep learning models in safety-critical applications, ensuring that the decisions of such models are robust against adversarial exploitation is of fundamental importance. In this thesis, we discuss recent…

Machine Learning · Computer Science 2025-09-24 Alexander Robey

At the intersection of the rapidly growing biological data landscape and advancements in Natural Language Processing (NLP), protein language models (PLMs) have emerged as a transformative force in modern research. These models have achieved…

Biomolecules · Quantitative Biology 2025-02-12 Lei Wang , Xudong Li , Han Zhang , Jinyi Wang , Dingkang Jiang , Zhidong Xue , Yan Wang

Although pre-trained language models (PrLMs) have achieved significant success, recent studies demonstrate that PrLMs are vulnerable to adversarial attacks. By generating adversarial examples with slight perturbations on different levels…

Computation and Language · Computer Science 2022-08-23 Jiayi Wang , Rongzhou Bao , Zhuosheng Zhang , Hai Zhao

Adversarial Training has proved to be an effective training paradigm to enforce robustness against adversarial examples in modern neural network architectures. Despite many efforts, explanations of the foundational principles underpinning…

Computer Vision and Pattern Recognition · Computer Science 2022-03-18 Mattia Carletti , Matteo Terzi , Gian Antonio Susto

Proteins are fundamental biological entities that play a key role in life activities. The amino acid sequences of proteins can be folded into stable 3D structures in the real physicochemical world, forming a special kind of…

Machine Learning · Computer Science 2023-01-04 Lirong Wu , Yufei Huang , Haitao Lin , Stan Z. Li

Deciphering the function of unseen protein sequences is a fundamental challenge with broad scientific impact, yet most existing methods depend on task-specific adapters or large-scale supervised fine-tuning. We introduce the…

Machine Learning · Computer Science 2025-10-14 Xinhui Chen , Zuchao Li , Mengqi Gao , Yufeng Zhang , Chak Tou Leong , Haoyang Li , Jiaqi Chen

Beyond the success story of adversarial training (AT) in the recent text domain on top of pre-trained language models (PLMs), our empirical study showcases the inconsistent gains from AT on some tasks, e.g. commonsense reasoning, named…

Computation and Language · Computer Science 2023-05-09 Hongqiu Wu , Yongxiang Liu , Hanwen Shi , Hai Zhao , Min Zhang

Natural language inference (NLI) is among the most challenging tasks in natural language understanding. Recent work on unsupervised pretraining that leverages unsupervised signals such as language-model and sentence prediction objectives…

Computation and Language · Computer Science 2019-04-30 Tianda Li , Xiaodan Zhu , Quan Liu , Qian Chen , Zhigang Chen , Si Wei

Process Reward Models (PRMs) enhance reasoning ability of LLMs by providing step-level supervision. However, their widespread adoption is limited due to expensive manual step-level annotation and poor generalization of static training data…

Machine Learning · Computer Science 2025-12-01 Gurusha Juneja , Deepak Nathani , William Yang Wang

Adversarial training, a method for learning robust deep neural networks, constructs adversarial examples during training. However, recent methods for generating NLP adversarial examples involve combinatorial search and expensive sentence…

Computation and Language · Computer Science 2021-09-14 Jin Yong Yoo , Yanjun Qi

In this paper we proposed a novel Adversarial Training (AT) approach for end-to-end speech recognition using a Criticizing Language Model (CLM). In this way the CLM and the automatic speech recognition (ASR) model can challenge and learn…

Computation and Language · Computer Science 2018-11-05 Alexander H. Liu , Hung-yi Lee , Lin-shan Lee

Pre-trained language models (PLMs) have been widely used to underpin various downstream tasks. However, the adversarial attack task has found that PLMs are vulnerable to small perturbations. Mainstream methods adopt a detached two-stage…

Computation and Language · Computer Science 2023-05-30 Xuanjie Fang , Sijie Cheng , Yang Liu , Wei Wang

Although current deep learning techniques have yielded superior performance on various computer vision tasks, yet they are still vulnerable to adversarial examples. Adversarial training and its variants have been shown to be the most…

Computer Vision and Pattern Recognition · Computer Science 2022-11-02 Junhao Dong , Seyed-Mohsen Moosavi-Dezfooli , Jianhuang Lai , Xiaohua Xie

Protein language models (PLMs) have shown promise in improving the understanding of protein sequences, contributing to advances in areas such as function prediction and protein engineering. However, training these models from scratch…

Machine Learning · Computer Science 2024-12-19 Shivasankaran Vanaja Pandi , Bharath Ramsundar

Protein language models (PLMs) have advanced computational protein science through large-scale pretraining and scalable architectures. In parallel, reinforcement learning (RL) has broadened exploration and enabled precise multi-objective…

Autoregressive Large Language Models have transformed the landscape of Natural Language Processing. Pre-train and prompt paradigm has replaced the conventional approach of pre-training and fine-tuning for many downstream NLP tasks. This…

Computation and Language · Computer Science 2024-04-18 Prabin Bhandari

In Natural Language Processing (NLP), pretrained language models (LMs) that are transferred to downstream tasks have been recently shown to achieve state-of-the-art results. However, standard fine-tuning can degrade the general-domain…

Machine Learning · Computer Science 2020-10-07 Giorgos Vernikos , Katerina Margatina , Alexandra Chronopoulou , Ion Androutsopoulos

Protein-specific large language models (Protein LLMs) are revolutionizing protein science by enabling more efficient protein structure prediction, function annotation, and design. While existing surveys focus on specific aspects or…