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Generative models are now used to create a variety of high-quality digital artifacts. Yet their use in designing physical objects has received far less attention. In this paper, we advocate for the construction toy, LEGO, as a platform for…

Artificial Intelligence · Computer Science 2020-12-22 Rylee Thompson , Elahe Ghalebi , Terrance DeVries , Graham W. Taylor

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

Machine learning in drug discovery has been focused on virtual screening of molecular libraries using discriminative models. Generative models are an entirely different approach that learn to represent and optimize molecules in a continuous…

Quantitative Methods · Quantitative Biology 2020-11-17 Matthew Ragoza , Tomohide Masuda , David Ryan Koes

We present a probabilistic deep learning methodology that enables the construction of predictive data-driven surrogates for stochastic systems. Leveraging recent advances in variational inference with implicit distributions, we put forth a…

Machine Learning · Statistics 2019-01-16 Yibo Yang , Paris Perdikaris

Generative adversarial networks (GANs) has gained tremendous popularity lately due to an ability to reinforce quality of its predictive model with generated objects and the quality of the generative model with and supervised feedback. GANs…

Computer Vision and Pattern Recognition · Computer Science 2017-05-31 Evgeny Zamyatin , Andrey Filchenkov

Supervised machine learning describes the practice of fitting a parameterized model to labeled input-output data. Supervised machine learning methods have demonstrated promise in learning efficient surrogate models that can (partially)…

Machine Learning · Statistics 2026-03-24 Atticus Rex , Elizabeth Qian , David Peterson

Generative neural networks can produce data samples according to the statistical properties of their training distribution. This feature can be used to test modern computational neuroscience hypotheses suggesting that spontaneous brain…

Neural and Evolutionary Computing · Computer Science 2025-07-29 Lorenzo Tausani , Alberto Testolin , Marco Zorzi

Learning representations of molecular structures using deep learning is a fundamental problem in molecular property prediction tasks. Molecules inherently exist in the real world as three-dimensional structures; furthermore, they are not…

Machine Learning · Computer Science 2024-01-22 Daiki Koge , Naoaki Ono , Shigehiko Kanaya

We use a coarse-grained model of DNA-functionalized particles to understand the role of DNA chain length on their self-assembly. We find that the increasing chain length for a given particle size decreases the propensity to form ordered…

Soft Condensed Matter · Physics 2020-01-07 Runfang Mao , Jeetain Mittal

Industrial robots can solve very complex tasks in controlled environments, but modern applications require robots able to operate in unpredictable surroundings as well. An increasingly popular reactive policy architecture in robotics is…

Robotics · Computer Science 2021-03-17 Jonathan Styrud , Matteo Iovino , Mikael Norrlöf , Mårten Björkman , Christian Smith

Inspired by the recent advances in generative models, we introduce a human action generation model in order to generate a consecutive sequence of human motions to formulate novel actions. We propose a framework of an autoencoder and a…

Computer Vision and Pattern Recognition · Computer Science 2018-05-29 Mohammad Ahangar Kiasari , Dennis Singh Moirangthem , Minho Lee

Generative models have advantageous characteristics for classification tasks such as the availability of unsupervised data and calibrated confidence, whereas discriminative models have advantages in terms of the simplicity of their model…

Machine Learning · Computer Science 2023-05-11 Hideaki Hayashi

Learning to interact with the environment not only empowers the agent with manipulation capability but also generates information to facilitate building of action understanding and imitation capabilities. This seems to be a strategy adopted…

Robotics · Computer Science 2022-12-06 M. Y. Seker , A. Ahmetoglu , Y. Nagai , M. Asada , E. Oztop , E. Ugur

The field of RNA secondary structure prediction has made significant progress with the adoption of deep learning techniques. In this work, we present the RNAformer, a lean deep learning model using axial attention and recycling in the…

Machine Learning · Computer Science 2023-07-20 Jörg K. H. Franke , Frederic Runge , Frank Hutter

As generative AI achieves hyper-realism, superficial artifact detection has become obsolete. While prevailing methods rely on resource-intensive fine-tuning of black-box backbones, we propose that forgery detection capability is already…

Computer Vision and Pattern Recognition · Computer Science 2026-02-02 Jingtong Dou , Chuancheng Shi , Yemin Wang , Shiming Guo , Anqi Yi , Wenhua Wu , Li Zhang , Fei Shen , Tat-Seng Chua

Predictive models are a crucial component of many robotic systems. Yet, constructing accurate predictive models for a variety of deformable objects, especially those with unknown physical properties, remains a significant challenge. This…

Robotics · Computer Science 2024-07-11 Kaifeng Zhang , Baoyu Li , Kris Hauser , Yunzhu Li

Nanomaterial research is becoming a vital area for energy, medicine, and materials science, and accurate analysis of the nanoparticle topology is essential to determine their properties. Unfortunately, the lack of high-quality annotated…

Computer Vision and Pattern Recognition · Computer Science 2025-05-26 Varun Ajith , Anindya Pal , Saumik Bhattacharya , Sayantari Ghosh

Object manipulation is a natural activity we perform every day. How humans handle objects can communicate not only the willfulness of the acting, or key aspects of the context where we operate, but also the properties of the objects…

Unsupervised learning of generative models has seen tremendous progress over recent years, in particular due to generative adversarial networks (GANs), variational autoencoders, and flow-based models. GANs have dramatically improved sample…

Computer Vision and Pattern Recognition · Computer Science 2020-01-06 Thomas Lucas , Konstantin Shmelkov , Karteek Alahari , Cordelia Schmid , Jakob Verbeek

3D generative modeling is accelerating as the technology allowing the capture of geometric data is developing. However, the acquired data is often inconsistent, resulting in unregistered meshes or point clouds. Many generative learning…

Computer Vision and Pattern Recognition · Computer Science 2023-06-29 Thomas Besnier , Sylvain Arguillère , Emery Pierson , Mohamed Daoudi