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One of the major research questions regarding human microbiome studies is the feasibility of designing interventions that modulate the composition of the microbiome to promote health and cure disease. This requires extensive understanding…

Methodology · Statistics 2021-11-18 Matthew D. Koslovsky , Kristi L. Hoffman , Carrie R. Daniel , Marina Vannucci

We propose a Bayesian approach for model-based clustering of multivariate categorical data where variables are allowed to be associated within clusters and the number of clusters is unknown. The approach uses a two-layer mixture of finite…

Methodology · Statistics 2024-07-09 Gertraud Malsiner-Walli , Bettina Grün , Sylvia Frühwirth-Schnatter

Current methods for learning graphical models with latent variables and a fixed structure estimate optimal values for the model parameters. Whereas this approach usually produces overfitting and suboptimal generalization performance,…

Machine Learning · Computer Science 2013-01-30 Hagai Attias

Prompt isolated leptons are essential in many analyses in high-energy particle physics but are subject to fake-lepton background, i.e. objects that mimic the lepton signature. The fake-lepton background is difficult to estimate from…

High Energy Physics - Phenomenology · Physics 2022-07-25 Johannes Erdmann , Cornelius Grunwald , Kevin Kröninger , Salvatore La Cagnina , Lars Röhrig , Erich Varnes

Mass spectrometry-based metabolomic analysis depends upon the identification of spectral peaks by their mass and retention time. Statistical analysis that follows the identification currently relies on one main peak of each compound.…

Quantitative Methods · Quantitative Biology 2014-03-20 Tommi Suvitaival , Simon Rogers , Samuel Kaski

The analysis of longitudinal categorical data can be complex and unfeasible due to the number of parameters involved, characterised by overparameterisation leading to model non-convergence, in addition to problems related to sample size and…

The present paper proposes a novel Bayesian, computational strategy in the context of model-based inverse problems in elastostatics. On one hand we attempt to provide probabilistic estimates of the material properties and their spatial…

Computation · Statistics 2015-12-21 P. S. Koutsourelakis

A family of parsimonious shifted asymmetric Laplace mixture models is introduced. We extend the mixture of factor analyzers model to the shifted asymmetric Laplace distribution. Imposing constraints on the constitute parts of the resulting…

Methodology · Statistics 2013-11-05 Brian C. Franczak , Paul D. McNicholas , Ryan P. Browne , Paula M. Murray

We continue studies of the uncertainty quantification problem in emission tomographies such as PET or SPECT when additional multimodal data (e.g., anatomical MRI images) are available. To solve the aforementioned problem we adapt the…

Machine Learning · Statistics 2021-12-03 Fedor Goncharov , Éric Barat , Thomas Dautremer

Understanding covariate-varying interdependencies among features is of great interest in various applications. Motivated by microbiome studies where microbial abundances and interactions vary with environmental factors, we develop a…

Methodology · Statistics 2026-03-16 Shuangjie Zhang , Michael L. Patnode , Juhee Lee

Bayesian sparse factor models have proven useful for characterizing dependence in multivariate data, but scaling computation to large numbers of samples and dimensions is problematic. We propose expandable factor analysis for scalable…

Methodology · Statistics 2018-06-21 Sanvesh Srivastava , Barbara E. Engelhardt , David B. Dunson

Bayesian inference and the use of posterior or posterior predictive probabilities for decision making have become increasingly popular in clinical trials. The current practice in Bayesian clinical trials relies on a hybrid…

Methodology · Statistics 2024-04-30 Shirin Golchi , James Willard

Bayesian inference provides a rigorous methodology for estimation and uncertainty quantification of parameters in geophysical forward models. Badlands (basin and landscape dynamics model) is a landscape evolution model that simulates…

Quantitative genetic studies that model complex, multivariate phenotypes are important for both evolutionary prediction and artificial selection. For example, changes in gene expression can provide insight into developmental and…

Applications · Statistics 2013-05-03 Daniel E Runcie , Sayan Mukherjee

We have combined transmission speckle photography and machine learning for direct classification and recognition of milk fat content classes. Our aim was hinged on the fact that parameters of scattering particles (and the dispersion medium)…

Computer Vision and Pattern Recognition · Computer Science 2023-07-31 Kwasi Nyandey , Daniel Jakubczyk

Observations consisting of measurements on relationships for pairs of objects arise in many settings, such as protein interaction and gene regulatory networks, collections of author-recipient email, and social networks. Analyzing such data…

Methodology · Statistics 2010-02-22 Edoardo M Airoldi , David M Blei , Stephen E Fienberg , Eric P Xing

Methods utilizing instrumental variables have been a fundamental statistical approach to estimation in the presence of unmeasured confounding, usually occurring in non-randomized observational data common to fields such as economics and…

Methodology · Statistics 2022-10-06 Charles Spanbauer , Wei Pan

Undirected graphical models are widely used in statistics, physics and machine vision. However Bayesian parameter estimation for undirected models is extremely challenging, since evaluation of the posterior typically involves the…

Computation · Statistics 2012-03-19 Richard G. Everitt

Multi-view problems can be faced with latent variable models since they are able to find low-dimensional projections that fairly capture the correlations among the multiple views that characterise each datum. On the other hand,…

We consider model-based clustering methods for continuous, correlated data that account for external information available in the presence of mixed-type fixed covariates by proposing the MoEClust suite of models. These models allow…

Methodology · Statistics 2021-07-15 Keefe Murphy , Thomas Brendan Murphy