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In this work, we consider two kinds of model reduction techniques to simulate blood flow through the largest systemic arteries, where a stenosis is located in a peripheral artery i.e. in an artery that is located far away from the heart.…

Numerical Analysis · Mathematics 2018-10-09 Tobias Köppl , Gabriele Santin , Bernard Haasdonk , Rainer Helmig

Background - Pulmonary insufficiency is a consequence of transannular patch repair in Tetralogy of Fallot (ToF), leading to late morbidity and mortality. Transcatheter native outflow tract pulmonary valve replacement (TPVR) has become…

This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the…

Background. Despite the routine prescription of rate control therapy for atrial fibrillation (AF), clinical evidence demonstrating a heart rate target is lacking. Aim of the present study was to run a mathematical model simulating AF…

Physics-Informed Neural Networks (PINNs) show significant potential for solving inverse problems, especially when observations are limited and sparse, provided that the relevant physical equations are known. We use PINNs to estimate smooth…

Numerical Analysis · Mathematics 2025-08-06 Moises Sierpe , Ernesto Castillo , Hernan Mella , Felipe Galarce

Percutaneous catheter pumps are intraventricular temporary mechanical circulatory support (MCS) devices that are positioned across the aortic valve into the left ventricle (LV) and provide continuous antegrade blood flow from the LV into…

Medical Physics · Physics 2023-12-11 Greg W. Burgreen , Mansur Zhussupbekov , Rodrigo Méndez Rojano , James F. Antaki

Simulation of arterial stenting procedures prior to intervention allows for appropriate device selection as well as highlights potential complications. To this end, we present a framework for facilitating virtual aortic stenting from a…

Computer Vision and Pattern Recognition · Computer Science 2011-03-10 Jan Egger , Bernd Freisleben , Randolph Setser , Rahul Renapuraar , Christina Biermann , Thomas O'Donnell

Physics-based computer models based on numerical solution of the governing equations generally cannot make rapid predictions, which in turn, limits their applications in the clinic. To address this issue, we developed a physics-informed…

Computational Engineering, Finance, and Science · Computer Science 2024-10-14 Ehsan Naghavi , Haifeng Wang , Lei Fan , Jenny S. Choy , Ghassan Kassab , Seungik Baek , Lik-Chuan Lee

In this work, we develop patient-specific cardiocirculatory models with the aim of building Digital Twins for hypertension. In particular, in our pathophysiology-based framework, we consider both 0D cardiocirculatory models and a 3D-0D…

Numerical Analysis · Mathematics 2025-11-27 Simone Celora , Andrea Tonini , Francesco Regazzoni , Luca Dede' , Gianfranco Parati , Alfio Quarteroni

Due to the inter- and intra- variation of respiratory motion, it is highly desired to provide real-time volumetric images during the treatment delivery of lung stereotactic body radiation therapy (SBRT) for accurate and active motion…

Lumped method (Electrical analogy) is a quick and easy way to model human cardiovascular system. In this paper Lumped method is used for simulating a complete model. It describes a 36-vessel model and cardiac system of human body with…

This paper presents a recurrent neural network approach to simulating mechanical ventilator pressure. The traditional mechanical ventilator has a control pressure that is monitored by a medical practitioner and can behave incorrectly if the…

Distributed, Parallel, and Cluster Computing · Computer Science 2024-10-10 Su Diao , Changsong Wei , Junyu Wang , Yizhou Li

When a blood vessel ruptures or gets inflamed, the human body responds by rapidly forming a clot to restrict the loss of blood. Platelets aggregation at the injury site of the blood vessel occurring via platelet-platelet adhesion, tethering…

Tissues and Organs · Quantitative Biology 2015-06-18 Ziheng Wu , Zhiliang Xu , Oleg Kim , Mark Alber

Pulmonary diseases are a public health problem that requires accurate and fast diagnostic techniques. In this paper, a method based on convolutional neural networks (CNN), Data Augmentation, ResNet50 and Vision Transformers (ViT) is…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Pablo Ramirez Amador , Dinarle Milagro Ortega , Arnold Cesarano

Stenting is among the most common transcatheter interventions for congenital heart disease (CHD). Patient-specific computational fluid dynamics (CFD) simulations can predict hemodynamic outcomes of intervention scenarios but require…

Computational Engineering, Finance, and Science · Computer Science 2026-05-22 Bohan J. Li , Nicholas C. Dorn , Andras Lasso , Matthew A. Jolley , Jeffrey A. Feinstein , Doug L. James , Alison L. Marsden

Accurate simulation of blood flow in deformable vessels is critical in cardiovascular research for understanding disease progression and informing clinical decision-making. However, due to the thin-walled nature of arteries, traditional…

Computational Engineering, Finance, and Science · Computer Science 2026-01-05 Chenxi Zhao , Dong Wu , Weiyi Kong , Oskar J. Haidn , Xiangyu Hu

Early and accurate diagnosis of pulmonary hypertension (PH) is essential for optimal patient management. Differentiating between pre-capillary and post-capillary PH is critical for guiding treatment decisions. This study develops and…

Image and Video Processing · Electrical Eng. & Systems 2025-04-03 Fubao Zhu , Yang Zhang , Gengmin Liang , Jiaofen Nan , Yanting Li , Chuang Han , Danyang Sun , Zhiguo Wang , Chen Zhao , Wenxuan Zhou , Jian He , Yi Xu , Iokfai Cheang , Xu Zhu , Yanli Zhou , Weihua Zhou

Surgical simulators have been widely used in training and evaluation of physicians and surgeons. Virtual reality augmented with haptic technology has made it feasible to develop more realistic surgical simulators. In this context, we set…

Medical Physics · Physics 2022-05-19 Reza Karimzadeh , Javad Sheikh , Hamed Azarnoush , Hossein Arabi

High-quality 3D reconstruction of pulmonary segments plays a crucial role in segmentectomy and surgical planning for the treatment of lung cancer. Due to the resolution requirement of the target reconstruction, conventional deep…

Graphics · Computer Science 2025-12-16 Kangxian Xie , Yufei Zhu , Kaiming Kuang , Li Zhang , Hongwei Bran Li , Mingchen Gao , Jiancheng Yang

Current virtual reality (VR) training simulators of liver punctures often rely on static 3D patient data and use an unrealistic (sinusoidal) periodic animation of the respiratory movement. Existing methods for the animation of breathing…

Computer Vision and Pattern Recognition · Computer Science 2017-08-08 Andre Mastmeyer , Matthias Wilms , Heinz Handels