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Accurately modeling multi-class cell topology is crucial in digital pathology, as it provides critical insights into tissue structure and pathology. The synthetic generation of cell topology enables realistic simulations of complex tissue…

Image and Video Processing · Electrical Eng. & Systems 2025-03-26 Meilong Xu , Saumya Gupta , Xiaoling Hu , Chen Li , Shahira Abousamra , Dimitris Samaras , Prateek Prasanna , Chao Chen

Histopathology image classification is crucial for the accurate identification and diagnosis of various diseases but requires large and diverse datasets. Obtaining such datasets, however, is often costly and time-consuming due to the need…

Computer Vision and Pattern Recognition · Computer Science 2024-09-25 Leire Benito-Del-Valle , Aitor Alvarez-Gila , Itziar Eguskiza , Cristina L. Saratxaga

Artificial intelligence methods including deep neural networks (DNN) can provide rapid molecular classification of tumors from routine histology with accuracy that matches or exceeds human pathologists. Discerning how neural networks make…

Visual microscopic study of diseased tissue by pathologists has been the cornerstone for cancer diagnosis and prognostication for more than a century. Recently, deep learning methods have made significant advances in the analysis and…

Image and Video Processing · Electrical Eng. & Systems 2022-09-30 Puria Azadi Moghadam , Sanne Van Dalen , Karina C. Martin , Jochen Lennerz , Stephen Yip , Hossein Farahani , Ali Bashashati

One of the challenges of using machine learning techniques with medical data is the frequent dearth of source image data on which to train. A representative example is automated lung cancer diagnosis, where nodule images need to be…

Computer Vision and Pattern Recognition · Computer Science 2019-09-10 Steve Kommrusch , Louis-Noël Pouchet

Deep Learning (DL) models have been successfully applied to many applications including biomedical cell segmentation and classification in histological images. These models require large amounts of annotated data which might not always be…

Image and Video Processing · Electrical Eng. & Systems 2024-06-04 Roberto Basla , Loris Giulivi , Luca Magri , Giacomo Boracchi

Data-driven cell tracking and segmentation methods in biomedical imaging require diverse and information-rich training data. In cases where the number of training samples is limited, synthetic computer-generated data sets can be used to…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 David Wiesner , Julian Suk , Sven Dummer , Tereza Nečasová , Vladimír Ulman , David Svoboda , Jelmer M. Wolterink

Training computer-vision related algorithms on medical images for disease diagnosis or image segmentation is difficult due to the lack of training data, labeled samples, and privacy concerns. For this reason, a robust generative method to…

Image and Video Processing · Electrical Eng. & Systems 2021-11-04 Robert V Bergen , Jean-Francois Rajotte , Fereshteh Yousefirizi , Ivan S Klyuzhin , Arman Rahmim , Raymond T. Ng

Generating realistic tissue images with annotations is a challenging task that is important in many computational histopathology applications. Synthetically generated images and annotations are valuable for training and evaluating…

Image and Video Processing · Electrical Eng. & Systems 2024-04-08 Srijay Deshpande , Fayyaz Minhas , Nasir Rajpoot

Synthetic tumors in medical images offer controllable characteristics that facilitate the training of machine learning models, leading to an improved segmentation performance. However, the existing methods of tumor synthesis yield…

Computer Vision and Pattern Recognition · Computer Science 2025-09-04 Hongxu Yang , Edina Timko , Levente Lippenszky , Vanda Czipczer , Lehel Ferenczi

The limited availability of 3D medical image datasets, due to privacy concerns and high collection or annotation costs, poses significant challenges in the field of medical imaging. While a promising alternative is the use of synthesized…

Image and Video Processing · Electrical Eng. & Systems 2024-05-27 Lingting Zhu , Noel Codella , Dongdong Chen , Zhenchao Jin , Lu Yuan , Lequan Yu

In this paper, we propose a computational framework for 3D volume reconstruction from 2D histological slices using registration algorithms in feature space. To improve the quality of reconstructed 3D volume, first, intensity variations in…

Computer Vision and Pattern Recognition · Computer Science 2009-07-21 Ulas Bagci , Li Bai

Data scarcity in medical imaging poses significant challenges due to privacy concerns. Diffusion models, a recent generative modeling technique, offer a potential solution by generating synthetic and realistic data. However, questions…

Image and Video Processing · Electrical Eng. & Systems 2024-12-24 Abdullah al Nomaan Nafi , Md. Alamgir Hossain , Rakib Hossain Rifat , Md Mahabub Uz Zaman , Md Manjurul Ahsan , Shivakumar Raman

In the realm of dermatological diagnoses, where the analysis of dermatoscopic and microscopic skin lesion images is pivotal for the accurate and early detection of various medical conditions, the costs associated with creating diverse and…

Generative modelling and synthetic data can be a surrogate for real medical imaging datasets, whose scarcity and difficulty to share can be a nuisance when delivering accurate deep learning models for healthcare applications. In recent…

Image and Video Processing · Electrical Eng. & Systems 2024-02-27 Virginia Fernandez , Walter Hugo Lopez Pinaya , Pedro Borges , Mark S. Graham , Tom Vercauteren , M. Jorge Cardoso

The generation of 3D models from real-world objects has often been accomplished through photogrammetry, i.e., by taking 2D photos from a variety of perspectives and then triangulating matched point-based features to create a textured mesh.…

Computer Vision and Pattern Recognition · Computer Science 2026-02-13 Jacob Rubinstein , Avi Donaty , Don Engel

Due to privacy concerns, obtaining large datasets is challenging in medical image analysis, especially with 3D modalities like Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing generative models, developed to address…

Computer Vision and Pattern Recognition · Computer Science 2025-09-30 Jonghun Kim , Inye Na , Eun Sook Ko , Hyunjin Park

Novel multimodal imaging methods are capable of generating extensive, super high resolution datasets for preclinical research. Yet, a massive lack of annotations prevents the broad use of deep learning to analyze such data. So far, existing…

Image and Video Processing · Electrical Eng. & Systems 2021-04-26 Izabela Horvath , Johannes C. Paetzold , Oliver Schoppe , Rami Al-Maskari , Ivan Ezhov , Suprosanna Shit , Hongwei Li , Ali Ertuerk , Bjoern H. Menze

The usage of medical image data for the training of large-scale machine learning approaches is particularly challenging due to its scarce availability and the costly generation of data annotations, typically requiring the engagement of…

Computer Vision and Pattern Recognition · Computer Science 2024-06-26 Joshua Niemeijer , Jan Ehrhardt , Hristina Uzunova , Heinz Handels

Mainstream deep models for three-dimensional MRI synthesis are either cross-sectional or volumetric depending on the input. Cross-sectional models can decrease the model complexity, but they may lead to discontinuity artifacts. On the other…

Image and Video Processing · Electrical Eng. & Systems 2021-01-14 Muzaffer Özbey , Mahmut Yurt , Salman Ul Hassan Dar , Tolga Çukur
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