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Several brain disorders can be detected by observing alterations in the brain's structural and functional connectivities. Neurological findings suggest that early diagnosis of brain disorders, such as mild cognitive impairment (MCI), can…

Neurons and Cognition · Quantitative Biology 2021-10-22 Alpay Tekin , Ahmed Nebli , Islem Rekik

Drug-target interaction (DTI) prediction has become a foundational task in drug repositioning, polypharmacology, drug discovery, as well as drug resistance and side-effect prediction. DTI identification using machine learning is gaining…

Quantitative Methods · Quantitative Biology 2023-11-17 Konstantin Y. Kalitin , Alexey A. Nevzorov , Denis A. Babkov , Alexander A. Spasov , Olga Y. Mukha

Epilepsy is one of the most prevalent brain disorders that disrupts the lives of millions worldwide. For patients with drug-resistant seizures, there exist implantable devices capable of monitoring neural activity, promptly triggering…

Signal Processing · Electrical Eng. & Systems 2023-10-31 Arman Zarei , Bingzhao Zhu , Mahsa Shoaran

Epilepsy is one of the most common neurological disorders, affecting about 1% of the population at all ages. Detecting the development of epilepsy, i.e., epileptogenesis (EPG), before any seizures occur could allow for early interventions…

Machine Learning · Computer Science 2020-06-18 Diyuan Lu , Sebastian Bauer , Valentin Neubert , Lara Sophie Costard , Felix Rosenow , Jochen Triesch

Objective: Epileptic seizures are relatively common in critically-ill children admitted to the pediatric intensive care unit (PICU) and thus serve as an important target for identification and treatment. Most of these seizures have no…

Objectives: This study examined whether currently existing clinical structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (18FDG-PET) capabilities and board-certified radiologists' reports and…

Neurons and Cognition · Quantitative Biology 2024-11-08 Rowena Mobbs , Fatima Nasrallah , Xuan Vinh To , John Magnussen , Jennifer Batchelor , Edward Hsiao , Mark Walterfang

Mild traumatic brain injuries (mTBI) are a highly prevalent condition with heterogeneous outcomes between individuals. A key factor governing brain tissue deformation and the risk of mTBI is the rotational kinematics of the head.…

Machine learning head models (MLHMs) are developed to estimate brain deformation for early detection of traumatic brain injury (TBI). However, the overfitting to simulated impacts and the lack of generalizability caused by distributional…

Brain-computer interface (BCI) technologies have been widely used in many areas. In particular, non-invasive technologies such as electroencephalography (EEG) or near-infrared spectroscopy (NIRS) have been used to detect motor imagery,…

Human-Computer Interaction · Computer Science 2020-04-28 Zhe Sun , Zihao Huang , Feng Duan , Yu Liu

Brain stroke remains one of the principal causes of death and disability worldwide, yet most tabular-data prediction models still hover below the 95% accuracy threshold, limiting real-world utility. Addressing this gap, the present work…

Quantitative Methods · Quantitative Biology 2026-05-22 Yousuf Islam , Md. Jalal Uddin Chowdhury , Sumon Chandra Das

Epileptic seizure detection from EEG signals remains challenging due to the high dimensionality and nonlinear, potentially stochastic, dynamics of neural activity. In this work, we investigate whether features derived from topological data…

Machine Learning · Computer Science 2026-04-15 Sunia Tanweer , Narayan Puthanmadam Subramaniyam , Firas A. Khasawneh

The analysis of brain connectivity aims to understand the emergence of functional networks into the brain. This information can be used in the process of electroencephalographic (EEG) signal analysis and classification for a braincomputer…

Neurons and Cognition · Quantitative Biology 2020-07-28 J. A. Gaxiola-Tirado

Background: Epilepsy is a neurological illness affecting the brain that makes people more likely to experience frequent, spontaneous seizures. There has to be an accurate automated method for measuring seizure frequency and severity in…

Signal Processing · Electrical Eng. & Systems 2023-05-09 Salim Rukhsar , Anil K. Tiwari

The accurate understanding of ischemic stroke lesions is critical for efficient therapy and prognosis of stroke patients. Magnetic resonance imaging (MRI) is sensitive to acute ischemic stroke and is a common diagnostic method for stroke.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-11 R. P. Chowdhury , T. Rahman

Brain Computer Interfaces (BCI) have become very popular with Electroencephalography (EEG) being one of the most commonly used signal acquisition techniques. A major challenge in BCI studies is the individualistic analysis required for each…

Signal Processing · Electrical Eng. & Systems 2019-11-28 Baani Leen Kaur Jolly , Palash Aggrawal , Surabhi S Nath , Viresh Gupta , Manraj Singh Grover , Rajiv Ratn Shah

Implantable, closed-loop devices for automated early detection and stimulation of epileptic seizures are promising treatment options for patients with severe epilepsy that cannot be treated with traditional means. Most approaches for early…

A core aim of neurocritical care is to prevent secondary brain injury. Spreading depolarizations (SDs) have been identified as an important independent cause of secondary brain injury. SDs are usually detected using invasive…

Signal Processing · Electrical Eng. & Systems 2026-05-19 Yinzhe Wu , Sharon Jewell , Xiaodan Xing , Yang Nan , Anthony J. Strong , Guang Yang , Martyn G. Boutelle

Epilepsy is the second most common brain disorder after migraine. Automatic detection of epileptic seizures can considerably improve the patients' quality of life. Current Electroencephalogram (EEG)-based seizure detection systems encounter…

Signal Processing · Electrical Eng. & Systems 2018-03-28 Ramy Hussein , Hamid Palangi , Rabab Ward , Z. Jane Wang

Stroke is a leading cause of mortality and disability. Emergent diagnosis and intervention are critical, and predicated upon initial brain imaging; however, existing clinical imaging modalities are generally costly, immobile, and demand…

In this paper, electroencephalography (EEG) measurements are used to infer change in cortical functional connectivity in response to change in audio stimulus. Experiments are conducted wherein the EEG activity of human subjects is recorded…

Signal Processing · Electrical Eng. & Systems 2018-02-20 Ketan Mehta , Joerg Kliewer