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It has been shown in the literature that marijuana use is associated with changes in brain network connectivity. We propose large-scale Extended Granger Causality (lsXGC) and investigate whether it can capture such changes using…

Machine Learning · Computer Science 2021-01-07 M. Ali Vosoughi , Axel Wismuller

It is a challenging research endeavor to infer causal relationships in multivariate observational time-series. Such data may be represented by graphs, where nodes represent time-series, and edges directed causal influence scores between…

Information Theory · Computer Science 2022-05-09 Axel Wismüller , Ali Vosoughi , Adora DSouza , Anas Abidin

In the present research, the effectiveness of large-scale Augmented Granger Causality (lsAGC) as a tool for gauging brain network connectivity was examined to differentiate between marijuana users and typical controls by utilizing…

Signal Processing · Electrical Eng. & Systems 2024-10-25 Ali Vosoughi , Akhil Kasturi , Axel Wismueller

We introduce large-scale Augmented Granger Causality (lsAGC) as a method for connectivity analysis in complex systems. The lsAGC algorithm combines dimension reduction with source time-series augmentation and uses predictive time-series…

Neurons and Cognition · Quantitative Biology 2021-01-26 Axel Wismuller , M. Ali Vosoughi

Graph topology inference of network processes with co-evolving and interacting time-series is crucial for network studies. Vector autoregressive models (VAR) are popular approaches for topology inference of directed graphs; however, in…

Machine Learning · Computer Science 2020-11-18 M. Ali Vosoughi , Axel Wismuller

To gain insight into complex systems it is a key challenge to infer nonlinear causal directional relations from observational time-series data. Specifically, estimating causal relationships between interacting components in large systems…

Machine Learning · Computer Science 2021-11-04 Axel Wismüller , Adora M. DSouza , Anas Z. Abidin

Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Junhao Zhang , Vishwanatha M. Rao , Ye Tian , Yanting Yang , Nicolas Acosta , Zihan Wan , Pin-Yu Lee , Chloe Zhang , Lawrence S. Kegeles , Scott A. Small , Jia Guo

Schizophrenia is a debilitating, chronic mental disorder that significantly impacts an individual's cognitive abilities, behavior, and social interactions. It is characterized by subtle morphological changes in the brain, particularly in…

Computer Vision and Pattern Recognition · Computer Science 2024-09-04 Nagur Shareef Shaik , Teja Krishna Cherukuri , Vince Calhoun , Dong Hye Ye

Clinical studies reveal disruptions in brain structural connectivity (SC) and functional connectivity (FC) in neuropsychiatric disorders such as schizophrenia (SZ). Traditional approaches might rely solely on SC due to limited functional…

Image and Video Processing · Electrical Eng. & Systems 2026-01-27 Badhan Mazumder , Ayush Kanyal , Lei Wu , Vince D. Calhoun , Dong Hye Ye

This paper is motivated by studies in neuroscience experiments to understand interactions between nodes in a brain network using different types of data modalities that capture different distinct facets of brain activity. To assess…

Schizophrenia and bipolar disorder are debilitating psychiatric illnesses that can be challenging to diagnose accurately. The similarities between the diseases make it difficult to differentiate between them using traditional diagnostic…

Empirical studies over the past two decades have supported the hypothesis that schizophrenia is characterized by altered connectivity patterns in functional brain networks. These alterations have been proposed as genetically-mediated…

Neurons and Cognition · Quantitative Biology 2013-06-28 Felix Siebenhuhner , Shennan A. Weiss , Richard Coppola , Daniel R. Weinberger , Danielle S. Bassett

Smart systems that can accurately diagnose patients with mental disorders and identify effective treatments based on brain functional imaging data are of great applicability and are gaining much attention. Most previous machine learning…

Computer Vision and Pattern Recognition · Computer Science 2017-12-05 Jumana Dakka , Pouya Bashivan , Mina Gheiratmand , Irina Rish , Shantenu Jha , Russell Greiner

Schizophrenia is a serious psychiatric disorder. Its pathogenesis is not completely clear, making it difficult to treat patients precisely. Because of the complicated non-Euclidean network structure of the human brain, learning critical…

Computer Vision and Pattern Recognition · Computer Science 2024-08-28 Yuhong Jiao , Jiaqing Miao , Jinnan Gong , Hui He , Ping Liang , Cheng Luo , Ying Tan

In spite of years of research, the mechanisms that underlie the development of schizophrenia, as well as its relapse, symptomatology, and treatment, continue to be a mystery. The absence of appropriate analytic tools to deal with the…

Computer Vision and Pattern Recognition · Computer Science 2022-10-12 Vigneshwaran Shankaran , Bhaskaran V

Functional connectivity (FC) has been widely used to study brain network interactions underlying the emerging cognition and behavior of an individual. FC is usually defined as the correlation or partial correlation between brain regions.…

Applications · Statistics 2020-10-27 Gemeng Zhang , Aiying Zhang , Biao Cai , Zhuozhuo Tu , Vince D. Calhoun , Yu-Ping Wang

The human brain has a complex, intricate functional architecture. While many studies primarily emphasize pairwise interactions, delving into high-order associations is crucial for a comprehensive understanding of how functional brain…

Neurons and Cognition · Quantitative Biology 2023-10-30 Qiang Li , Vince D. Calhoun , Adithya Ram Ballem , Shujian Yu , Jesus Malo , Armin Iraji

Granger causality (GC), a popular statistical method for the inference of directional influences between time series measured from a complex network, is sensitive to high-order (non-pairwise) interactions which fundamentally shape the…

Schizophrenia is a complicated mental illness characterized by a broad spectrum of symptoms affecting cognition, behavior, and emotion. The task of identifying reliable biomarkers to classify Schizophrenia accurately continues to be a…

Machine Learning · Computer Science 2023-11-22 Pradnya Rajendra Jadhav , Raviprasad Aduri

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis
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