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Protein-ligand binding affinity is critical in drug discovery, but experimentally determining it is time-consuming and expensive. Artificial intelligence (AI) has been used to predict binding affinity, significantly accelerating this…

Emerging Technologies · Computer Science 2025-09-16 Seon-Geun Jeong , Kyeong-Hwan Moon , Won-Joo Hwang

Problem instances of a size suitable for practical applications are not likely to be addressed during the noisy intermediate-scale quantum (NISQ) period with (almost) pure quantum algorithms. Hybrid classical-quantum algorithms have…

Quantum Physics · Physics 2022-12-05 Randall Correll , Sean J. Weinberg , Fabio Sanches , Takanori Ide , Takafumi Suzuki

Recent advancements in quantum computing (QC) and machine learning (ML) have garnered significant attention, leading to substantial efforts toward the development of quantum machine learning (QML) algorithms to address a variety of complex…

Quantum Physics · Physics 2024-12-18 Samuel Yen-Chi Chen

High-throughput approximations of quantum mechanics calculations and combinatorial experiments have been traditionally used to reduce the search space of possible molecules, drugs and materials. However, the interplay of structural and…

Quantum Physics · Physics 2019-10-29 Alain Tchagang , Julio Valdés

The development of quantum computers has been the stimulus that enables the realization of Quantum Machine Learning (QML), an area that integrates the calculational framework of quantum mechanics with the adaptive properties of classical…

Computational Engineering, Finance, and Science · Computer Science 2025-09-04 Bhavna Bose , Saurav Verma

With the fast development of quantum computing and deep learning, quantum neural networks have attracted great attention recently. By leveraging the power of quantum computing, deep neural networks can potentially overcome computational…

Machine Learning · Computer Science 2022-06-30 Qi Xia , Qun Li

The enormous successes have been made by quantum algorithms during the last decade. In this paper, we combine the quantum random walk (QRW) with the problem of data clustering, and develop two clustering algorithms based on the one…

Machine Learning · Computer Science 2008-12-09 Qiang Li , Yan He , Jing-ping Jiang

Quantum walks (QWs) are of interest as examples of uniquely quantum behavior and are applicable in a variety of quantum search and simulation models. Implementing QWs on quantum devices is useful from both points of view. We describe a…

Quantum Physics · Physics 2020-09-08 Asif Shakeel

We develop an hybrid quantum-classical algorithm to solve an optimal population transfer problem for a molecule subject to a laser pulse. The evolution of the molecular wavefunction under the laser pulse is simulated on a quantum computer,…

Quantum Physics · Physics 2021-02-25 Davide Castaldo , Marta Rosa , Stefano Corni

A new model of nonlinear charged quantum relativistic fluids is presented. This model can be discretized into Discrete Time Quantum Walks (DTQWs), and a new hybrid (quantum-classical) algorithm for implementing these walks on NISQ devices…

We consider the problem of distinguishing two vectors (visualized as images or barcodes) and learning if they are related to one another. For this, we develop a geometric quantum machine learning (GQML) approach with embedded symmetries…

Quantum Physics · Physics 2024-09-04 Chukwudubem Umeano , Stefano Scali , Oleksandr Kyriienko

The classification of big data usually requires a mapping onto new data clusters which can then be processed by machine learning algorithms by means of more efficient and feasible linear separators. Recently, Lloyd et al. have advanced the…

Quantum walks provide a framework for understanding and designing quantum algorithms that is both intuitive and universal. To leverage the computational power of these walks, it is important to be able to programmably modify the graph a…

Quantum Physics · Physics 2022-09-07 Aaron W. Young , William J. Eckner , Nathan Schine , Andrew M. Childs , Adam M. Kaufman

Molecular spin qudits based on lanthanide complexes offer a promising platform for quantum technologies, combining chemical tunability with multi-level encoding. However, experimental demonstrations of their envisaged capabilities remain…

Simulating quantum many-body systems is believed to be one of the most promising applications of near-term noisy quantum computers. However, in the near term, system size limitation will remain a severe barrier for applications in materials…

Strongly Correlated Electrons · Physics 2024-05-10 Anshumitra Baul , Herbert F Fotso , Hanna Terletska , Juana Moreno , Ka-Ming Tam

Major obstacles remain to the implementation of macroscopic quantum computing: hardware problems of noise, decoherence, and scaling; software problems of error correction; and, most important, algorithm construction. Finding truly quantum…

Quantum Physics · Physics 2020-07-17 Nathan Thompson , James Steck , Elizabeth Behrman

Multi-dimensional quantum walks can exhibit highly non-trivial topological structure, providing a powerful tool for simulating quantum information and transport systems. We present a flexible implementation of a 2D optical quantum walk on a…

Accurate prediction of protein active-site structures remains a central challenge in structural biology, particularly for short and flexible peptide fragments where conventional and simulation-based methods often fail. Here, we present a…

Quantum walks are promising tools based on classical random walks, with plenty of applications such as many variants of optimization. Here we introduce the semiclassical walks in discrete time, which are algorithms that combines classical…

Quantum Physics · Physics 2023-07-25 Sergio A. Ortega , Miguel A. Martin-Delgado

Quantum computing has the potential to solve complex problems faster and more efficiently than classical computing. It can achieve speedups by leveraging quantum phenomena like superposition, entanglement, and tunneling. Quantum walks (QWs)…

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