Related papers: Desynchrony and synchronisation underpinning sleep…
Daylight plays a major role in the wake/sleep cycle in humans. Indeed, the wake/sleep system stems from biological systems that follow a circadian rhythm determined by the light/dark alternation. The oscillations can be modeled by the…
Conditions such as insomnia, cardiac arrhythmia and jet-lag share a common feature: they are all related to the ability of biological systems to synchronize with the day-night cycle. When organisms lose resilience, this ability of…
Neural synchronization is believed to be critical for many brain functions. It frequently exhibits temporal variability, but it is not known if this variability has a specific temporal patterning. This study explores these…
Transitions in the dynamics of complex systems can be characterized by changes in the synchronization behavior of their components. Taking the human cardio-respiratory system as an example and using an automated procedure for screening the…
Sleep is essential for the maintenance of the brain and the body, yet many features of sleep are poorly understood and mathematical models are an important tool for probing proposed biological mechanisms. The most well-known mathematical…
Sleep is characterized by non-rapid eye movement (nREM) sleep, originating from widespread neuronal synchrony, and REM sleep, with neuronal desynchronization akin to waking behavior. While these were thought to be global brain states,…
Differential equation-based physiological models of sleep-wake networks describe sleep-wake regulation by simulating the activity of wake- and sleep-promoting neuronal populations and the modulation of these populations by homeostatic and…
Circadian rhythms in mammals are controlled by the neurons located in the suprachiasmatic nucleus of the hypothalamus. In physiological conditions, the system of neurons is very efficiently entrained by the 24-hour light-dark cycle. Most of…
Recent advances in sleep neurobiology have allowed development of physiologically based mathematical models of sleep regulation that account for the neuronal dynamics responsible for the regulation of sleep-wake cycles and allow detailed…
Circadian rhythmicity lies at the center of various important physiological and behavioral processes in mammals, such as sleep, metabolism, homeostasis, mood changes and more. It has been shown that this rhythm arises from self-sustained…
It is widely assumed that neural activity related to synchronous rhythms of large portions of neurons in specific locations of the brain is responsible for the pathology manifested in patients' uncontrolled tremor and other similar…
The study of synchronization in biological systems is essential for the understanding of the rhythmic phenomena of living organisms at both molecular and cellular levels. In this paper, by using simple dynamical systems theory, we present a…
The mammalian circadian system comprises a network of cell-autonomous oscillators, spanning from the central clock in the brain to peripheral clocks in other organs. These clocks are tightly coordinated to orchestrate rhythmic physiological…
Sleep disturbances, particularly nighttime waking, are highly prevalent in young children and can significantly disrupt not only the child's well-being but also family functioning. Behavioral and environmental strategies, including the…
A model and analysis of the human sleep/wake system is presented. The model is derived using the known neuronal groups, and their various projections, involved with sleep and wake. Inherent in the derivation is the existence of a slow time…
Three abilities - the ability to recognize sounds, the ability to visually recognize movement and the ability to keep an upright standing position - can function only with using precise measurements of the short time intervals. Other…
We show that the unavoidable increase in neuronal response latency to ongoing stimulation serves as a nonuniform gradual stretching of neuronal circuit delay loops and emerges as an essential mechanism in the formation of various types of…
The dynamics of three mutually coupled cortical neurons with time delays in the coupling are explored numerically and analytically. The neurons are coupled in a line, with the middle neuron sending a somewhat stronger projection to the…
Much work has been done to investigate social jetlag, a misalignment between the biological clock and the social agenda caused by exposition to different light inputs, that causes several health issues. To investigate synchronization and…
Circadian clocks are biochemical oscillators that allow organisms to estimate the time of the day. These oscillators are inherently noisy due to the discrete nature of the reactants and the stochastic character of their interactions. To…