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Few-shot learning is a standard practice in most deep learning based histopathology image segmentation, given the relatively low number of digitized slides that are generally available. While many models have been developed for domain…

Image and Video Processing · Electrical Eng. & Systems 2021-10-01 Zheng Yuan , Andre Esteva , Ran Xu

Semantic segmentation in a supervised learning manner has achieved significant progress in recent years. However, its performance usually drops dramatically due to the data-distribution discrepancy between seen and unseen domains when we…

Computer Vision and Pattern Recognition · Computer Science 2021-09-01 Jian Zhang , Lei Qi , Yinghuan Shi , Yang Gao

Labeling medical images is a major bottleneck in the field of medical imaging, as it requires domain-specific expertise, and it gets further complicated due to variability across different medical centers and different imaging devices. Such…

Computer Vision and Pattern Recognition · Computer Science 2026-05-06 Sapna Sachan , Rakesh Kumar Sanodiya , Amulya Kumar Mahto

Recent advances in deep learning for medical image segmentation demonstrate expert-level accuracy. However, in clinically realistic environments, such methods have marginal performance due to differences in image domains, including…

Computer Vision and Pattern Recognition · Computer Science 2019-06-13 Ling Zhang , Xiaosong Wang , Dong Yang , Thomas Sanford , Stephanie Harmon , Baris Turkbey , Holger Roth , Andriy Myronenko , Daguang Xu , Ziyue Xu

Achieving domain generalization in medical imaging poses a significant challenge, primarily due to the limited availability of publicly labeled datasets in this domain. This limitation arises from concerns related to data privacy and the…

Image and Video Processing · Electrical Eng. & Systems 2024-07-23 Ahmed Radwan , Islam Osman , Mohamed S. Shehata

Accurate and reliable histopathological image classification is essential for breast cancer diagnosis. However, many deep learning models remain sensitive to magnification variability and lack interpretability. To address these challenges,…

Computer Vision and Pattern Recognition · Computer Science 2026-03-17 Enam Ahmed Taufika , Md Ahasanul Arafatha , Abhijit Kumar Ghoshb , Md. Tanzim Rezab , Md Ashad Alamc

Generalising deep models to new data from new centres (termed here domains) remains a challenge. This is largely attributed to shifts in data statistics (domain shifts) between source and unseen domains. Recently, gradient-based…

Computer Vision and Pattern Recognition · Computer Science 2021-10-05 Xiao Liu , Spyridon Thermos , Alison O'Neil , Sotirios A. Tsaftaris

Annotating medical imaging datasets is costly, so fine-tuning (or transfer learning) is the most effective method for digital pathology vision applications such as disease classification and semantic segmentation. However, due to texture…

Computer Vision and Pattern Recognition · Computer Science 2023-08-23 Tushar Kataria , Beatrice Knudsen , Shireen Elhabian

Recently, we have witnessed great progress in the field of medical imaging classification by adopting deep neural networks. However, the recent advanced models still require accessing sufficiently large and representative datasets for…

Computer Vision and Pattern Recognition · Computer Science 2020-10-30 Haoliang Li , YuFei Wang , Renjie Wan , Shiqi Wang , Tie-Qiang Li , Alex C. Kot

Mammographic screening is an effective method for detecting breast cancer, facilitating early diagnosis. However, the current need to manually inspect images places a heavy burden on healthcare systems, spurring a desire for automated…

Image and Video Processing · Electrical Eng. & Systems 2025-01-30 Ciaran Bench , Emir Ahmed , Spencer A. Thomas

Several studies indicate that deep learning models can learn to detect breast cancer from mammograms (X-ray images of the breasts). However, challenges with overfitting and poor generalisability prevent their routine use in the clinic.…

Image and Video Processing · Electrical Eng. & Systems 2025-02-05 Emir Ahmed , Spencer A. Thomas , Ciaran Bench

The application of supervised deep learning methods in digital pathology is limited due to their sensitivity to domain shift. Digital Pathology is an area prone to high variability due to many sources, including the common practice of…

Image and Video Processing · Electrical Eng. & Systems 2020-12-24 Jelica Vasiljević , Friedrich Feuerhake , Cédric Wemmert , Thomas Lampert

Deep networks are now ubiquitous in large-scale multi-center imaging studies. However, the direct aggregation of images across sites is contraindicated for downstream statistical and deep learning-based image analysis due to inconsistent…

Image and Video Processing · Electrical Eng. & Systems 2021-04-16 Mengwei Ren , Neel Dey , James Fishbaugh , Guido Gerig

Deep learning (DL) has shown remarkable success in various medical imaging data analysis applications. However, it remains challenging for DL models to achieve good generalization, especially when the training and testing datasets are…

Image and Video Processing · Electrical Eng. & Systems 2023-11-06 Yuemeng Li , Yong Fan

Automated digital histopathology image segmentation is an important task to help pathologists diagnose tumors and cancer subtypes. For pathological diagnosis of cancer subtypes, pathologists usually change the magnification of whole-slide…

Computer Vision and Pattern Recognition · Computer Science 2019-04-15 Hiroki Tokunaga , Yuki Teramoto , Akihiko Yoshizawa , Ryoma Bise

Breast cancer has the highest mortality among cancers in women. Computer-aided pathology to analyze microscopic histopathology images for diagnosis with an increasing number of breast cancer patients can bring the cost and delays of…

Computer Vision and Pattern Recognition · Computer Science 2020-03-03 Abhijeet Patil , Dipesh Tamboli , Swati Meena , Deepak Anand , Amit Sethi

Deep learning models have exhibited exceptional effectiveness in Computational Pathology (CPath) by tackling intricate tasks across an array of histology image analysis applications. Nevertheless, the presence of out-of-distribution data…

Image and Video Processing · Electrical Eng. & Systems 2023-10-31 Mostafa Jahanifar , Manahil Raza , Kesi Xu , Trinh Vuong , Rob Jewsbury , Adam Shephard , Neda Zamanitajeddin , Jin Tae Kwak , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Poor performance of quantitative analysis in histopathological Whole Slide Images (WSI) has been a significant obstacle in clinical practice. Annotating large-scale WSIs manually is a demanding and time-consuming task, unlikely to yield the…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Sarah Cechnicka , James Ball , Hadrien Reynaud , Callum Arthurs , Candice Roufosse , Bernhard Kainz

Multiple instance (MI) learning with a convolutional neural network enables end-to-end training in the presence of weak image-level labels. We propose a new method for aggregating predictions from smaller regions of the image into an…

Computer Vision and Pattern Recognition · Computer Science 2018-06-14 Heather D. Couture , J. S. Marron , Charles M. Perou , Melissa A. Troester , Marc Niethammer

Deep learning-based models in medical imaging often struggle to generalize effectively to new scans due to data heterogeneity arising from differences in hardware, acquisition parameters, population, and artifacts. This limitation presents…

Image and Video Processing · Electrical Eng. & Systems 2023-08-09 Sebastian Nørgaard Llambias , Mads Nielsen , Mostafa Mehdipour Ghazi