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The spectrum of mutations in a collection of cancer genomes can be described by a mixture of a few mutational signatures. The mutational signatures can be found using non-negative matrix factorization (NMF). To extract the mutational…

Methodology · Statistics 2022-11-02 Marta Pelizzola , Ragnhild Laursen , Asger Hobolth

Nonnegative matrix factorization (NMF) has become a very popular technique in machine learning because it automatically extracts meaningful features through a sparse and part-based representation. However, NMF has the drawback of being…

Machine Learning · Statistics 2012-12-07 Nicolas Gillis

Nonnegative Matrix Factorization (NMF), first proposed in 1994 for data analysis, has received successively much attention in a great variety of contexts such as data mining, text clustering, computer vision, bioinformatics, etc. In this…

Numerical Analysis · Mathematics 2019-03-05 Paola Favati , Grazia Lotti , Ornella Menchi , Francesco Romani

Nonnegative matrix factorization (NMF) is widely used for clustering with strong interpretability. Among general NMF problems, symmetric NMF is a special one that plays an important role in graph clustering where each element measures the…

Machine Learning · Computer Science 2023-11-07 Mengyuan Zhang , Kai Liu

Bayesian Poisson Non-Negative Matrix Factorization (NMF) is widely used to model count data, including in cancer mutational signature analysis. However, standard Gibbs samplers rely on computationally expensive Poisson augmentation, and…

Methodology · Statistics 2026-03-31 Jenna M. Landy , Nishanth Basava , Giovanni Parmigiani

Non-negative matrix factorization (NMF) is a key technique for feature extraction and widely used in source separation. However, existing algorithms may converge to poor local minima, or to one of several minima with similar objective value…

Machine Learning · Computer Science 2024-10-30 Youdong Guo , Timothy E. Holy

We propose a new variant of nonnegative matrix factorization (NMF), combining separability and sparsity assumptions. Separability requires that the columns of the first NMF factor are equal to columns of the input matrix, while sparsity…

Machine Learning · Computer Science 2020-06-16 Nicolas Nadisic , Arnaud Vandaele , Jeremy E. Cohen , Nicolas Gillis

Nonnegative matrix factorization (NMF) is a popular method used to reduce dimensionality in data sets whose elements are nonnegative. It does so by decomposing the data set of interest, $\mathbf{X}$, into two lower rank nonnegative matrices…

Methodology · Statistics 2021-07-05 Phillip Shreeves , Jeffrey L. Andrews , Xinchen Deng , Ramie Ali-Adeeb , Andrew Jirasek

Non-negative matrix factorization (NMF) has become a popular method for representing meaningful data by extracting a non-negative basis feature from an observed non-negative data matrix. Some of the unique features of this method in…

Optimization and Control · Mathematics 2022-11-15 Sajad Fathi Hafshejani , Zahra Moaberfard

When applying nonnegative matrix factorization (NMF), the rank parameter is generally unknown. This rank, called the nonnegative rank, is usually estimated heuristically since computing its exact value is NP-hard. In this work, we propose…

Machine Learning · Computer Science 2025-09-26 Andersen Ang , Waqas Bin Hamed , Hans De Sterck

We show how to incorporate information from labeled examples into nonnegative matrix factorization (NMF), a popular unsupervised learning algorithm for dimensionality reduction. In addition to mapping the data into a space of lower…

Machine Learning · Computer Science 2011-12-19 Youngmin Cho , Lawrence K. Saul

Mutational signatures are patterns of somatic mutations in tumor genomes that provide insights into underlying mutagenic processes and cancer origin. Developing reliable methods for their estimation is of growing importance in cancer…

Applications · Statistics 2025-02-04 Blake Hansen , Isabella N. Grabski , Giovanni Parmigiani , Roberta De Vito

Nonnegative matrix factorization (NMF) is a popular dimension reduction technique that produces interpretable decomposition of the data into parts. However, this decompostion is not generally identifiable (even up to permutation and…

Machine Learning · Computer Science 2016-04-05 W. Pan , F. Doshi-Velez

Non-negative Matrix Factorization (NMF) asks to decompose a (entry-wise) non-negative matrix into the product of two smaller-sized nonnegative matrices, which has been shown intractable in general. In order to overcome this issue, the…

Data Structures and Algorithms · Computer Science 2019-07-15 Zhihuai Chen , Yinan Li , Xiaoming Sun , Pei Yuan , Jialin Zhang

Non-negative matrix factorization (NMF) has become a popular machine learning approach to many problems in text mining, speech and image processing, bio-informatics and seismic data analysis to name a few. In NMF, a matrix of non-negative…

Numerical Analysis · Computer Science 2013-03-19 Hugo Van hamme

Non-negative matrix factorization (NMF) has previously been shown to be a useful decomposition for multivariate data. We interpret the factorization in a new way and use it to generate missing attributes from test data. We provide a joint…

Numerical Analysis · Computer Science 2010-07-05 Mithun Das Gupta

Symmetric Nonnegative Matrix Factorization (SNMF) models arise naturally as simple reformulations of many standard clustering algorithms including the popular spectral clustering method. Recent work has demonstrated that an elementary…

Computer Vision and Pattern Recognition · Computer Science 2016-09-20 Reza Borhani , Jeremy Watt , Aggelos Katsaggelos

Given a matrix $M$ (not necessarily nonnegative) and a factorization rank $r$, semi-nonnegative matrix factorization (semi-NMF) looks for a matrix $U$ with $r$ columns and a nonnegative matrix $V$ with $r$ rows such that $UV$ is the best…

Numerical Analysis · Mathematics 2015-10-28 Nicolas Gillis , Abhishek Kumar

Non-negative matrix factorization (NMF) is a common method for generating topic models from text data. NMF is widely accepted for producing good results despite its relative simplicity of implementation and ease of computation. One…

Machine Learning · Computer Science 2016-08-09 Brendan Gavin , Vijay Gadepally , Jeremy Kepner

Non-negative matrix factorization (NMF) is a recently developed technique for finding parts-based, linear representations of non-negative data. Although it has successfully been applied in several applications, it does not always result in…

Machine Learning · Computer Science 2007-05-23 Patrik O. Hoyer