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In this work we investigate the use of nanoporous carrier as drug delivery systems for hydrophobic molecules. By studying a model system made of porous silicon loaded with beta-carotene, we unveil a fundamental limitation of these carriers…

Soft Condensed Matter · Physics 2020-01-23 Chiara Piotto , Paolo Bettotti

Understanding transport subject to molecular-scale confinement is key to advancing nanofluidics, yet classical hydrodynamic laws often fail at these scales. Here, we study a model system: transport of toluene as a solvent and small…

Soft Condensed Matter · Physics 2025-06-12 A. Baer , P. Malgaretti , K. Hoellring , J. Harting , Ana-Suncana Smith

Nanoscale biosystems are widely used in numerous medical applications. The approaches for structure and function of the nanomachines that are available in the cell (natural nanomachines) are discussed. Molecular simulation studies have been…

Biological Physics · Physics 2016-09-08 Babu A Manjasetty , T. R. Gopalakrishnan Nair , Y. S. Ramaswamy

We present the state-of-the-art theoretical modeling, molecular simulation, and coarse-graining strategies for the transport of gases and liquids in nanoporous materials (pore size 1-100 nm). Special emphasis is placed on the transport of…

Soft Condensed Matter · Physics 2025-01-29 Alexander Schlaich , Jean-Louis Barrat , Benoit Coasne

Using a coarse-grained bead-spring model of flexible polymer chains, the structure of a polymeric nanodroplet adsorbed on a chemically decorated flat wall is investigated by means of Molecular Dynamics simulation. We consider sessile drops…

Soft Condensed Matter · Physics 2009-11-10 J. Yaneva , A. Milchev , K. Binder

In recent years, extracellular vesicles such have become promising carriers as the next-generation drug delivery platforms. Effective loading of exogenous cargos without compromising the extracellular vesicle membrane is a major challenge.…

Biomolecules · Quantitative Biology 2023-04-14 Khayrul Islam , Meghdad Razizadeh , Yaling Liu

The jumping-droplet condensation, namely the out-of-plane jumping of condensed droplets upon coalescence, has been a promising technical innovation in the fields of energy harvesting, droplet manipulation, thermal management, etc., yet is…

Fluid Dynamics · Physics 2024-08-26 Shan Gao , Jian Qu , Zhichun Liu , Weigang Ma

In this study, using nonequilibrium molecular dynamics simulation, the water flow in carbon nanocones is studied using the TIP4P/2005 rigid water model. The results demonstrate a nonuniform dependence of the flow on the cone apex angle and…

Drug delivery systems represent a promising strategy to treat cancer and to overcome the side effects of chemotherapy. In particular, polymeric nanocontainers have attracted major interest because of their structural and morphological…

Medical Physics · Physics 2020-01-10 G. Pontrelli , G. Toniolo , S. McGinty , D. Peri , S. Succi , C. Chatgilialoglu

This paper proposes a mathematical approach for robust control of a nanoscale drug delivery system in treatment of atherosclerosis. First, a new nonlinear lumped model is introduced for mass transport in the arterial wall, and its accuracy…

Systems and Control · Electrical Eng. & Systems 2021-11-24 Alireza Rowhanimanesh , Mohammad-R Akbarzadeh-T

Optical responsivity grants biomedical capsules additional capabilities, promoting them towards multifunctional theragnostic nanodevices. In this endeavor, screening candidates under conditions that closely resemble in situ environments is…

Droplets, sub-millilitre liquid volumes with at least one interface, have traditionally served as compartments for storing, transporting, and delivering materials. Beyond familiar applications in food, coatings, and consumer goods, they…

Soft Condensed Matter · Physics 2025-12-16 Joe Forth , Robert Malinowski , Giorgio Volpe

Emerging technologies based on liquid crystal (LC) materials increasingly leverage the presence of nanoscale defects, unlike the canonical application of LCs -- LC displays. The inherent nanoscale characteristics of LC defects present both…

Soft Condensed Matter · Physics 2017-02-20 Fred Fu , Nasser Mohieddin Abukhdeir

Water inside a nanocapillary becomes ordered, resulting in unconventional behavior. A profound enhancement of water flow inside nanometer thin capillaries made of graphene has been observed [B. Radha et.al., Nature (London) 538, 222…

Soft Condensed Matter · Physics 2018-09-05 M. Neek-Amal , A. Lohrasebi , M. Mousaei , F. Shayeganfar , B. Radha , F. M. Peeters

Lipid-based drug delivery systems are considered as promising vehicles for hydrophobic drug compounds. Lipid distribution within the droplet can affect drug loading capacity in these carriers. It is extremely challenging to determine the…

Computational Physics · Physics 2019-06-12 Maryam Khalkhali , Sarah Mohammadinejad , Farhad Khoeini , Kobra Rostamizadeh

Ordering nanoparticles into a desired super-structure is often crucial for their technological applications. We use molecular dynamics simulations to study the assembly of nanoparticles in a polymer brush randomly grafted to a planar…

Soft Condensed Matter · Physics 2017-12-11 Shengfeng Cheng , Mark J. Stevens , Gary S. Grest

Nanodroplets on chemically structured substrates move under the action of disjoining pressure induced forces. A detailed analysis of them shows that even in the absence of long-ranged lateral variations of the effective interface potential,…

Soft Condensed Matter · Physics 2009-11-13 A. Moosavi , M. Rauscher , S. Dietrich

We describe the design, construction, and operation of an apparatus utilizing a piezoelectric transducer for in-vacuum loading of nanoparticles into an optical trap for use in levitated optomechanics experiments. In contrast to commonly…

Pickering emulsions have been widely studied due to their good stability and potential applications. Nanocellulose including cellulose nanocrystals (CNCs), cellulose nanofibrils (CNFs), and bacterial cellulose nanofibrils (BCNFs) has…

Soft Condensed Matter · Physics 2023-08-02 Chuye Ji , Yixiang Wang

In this work, two real-time methods to transport magnetic nanowires confined in giant hybrid vesi-cles upon the application of different strategies are studied. The microscale carriers are either mag-netically guided through the viscous…