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We present an algorithm for accelerating the search of molecule's adsorption site based on global optimization of surface adsorbate geometries. Our approach uses a machine-learning interatomic potential (moment tensor potential) to…

Materials Science · Physics 2024-12-30 Olga Klimanova , Nikita Rybin , Alexander Shapeev

Global optimization of crystal compositions is a significant yet computationally intensive method to identify stable structures within chemical space. The specific physical properties linked to a three-dimensional atomic arrangement make…

Geometry optimization is an important task in quantum chemical calculations to analyze the characteristics of molecules. A top concern on it is a long execution time because time-consuming energy and gradient calculations are repeated…

Chemical Physics · Physics 2024-04-22 Satoshi Imamura , Akihiko Kasagi , Eiji Yoshida

Determination of atomic structures is a key challenge in the fields of computational physics and materials science, as a large variety of mechanical, chemical, electronic, and optical properties depend sensitively on structure. Here, we…

Computational Physics · Physics 2021-06-02 Sami Kaappa , Estefanía Garijo del Río , Karsten Wedel Jacobsen

In component shape optimization, the component properties are often evaluated by computationally expensive simulations. Such optimization becomes unfeasible when it is focused on a global search requiring thousands of simulations to be…

Computational Engineering, Finance, and Science · Computer Science 2025-12-08 Lucie Kubíčková , Onřej Gebouský , Jan Haidl , Martin Isoz

Density functional theory (DFT) is probably the most promising approach for quantum chemistry calculations considering its good balance between calculations precision and speed. In recent years, several neural network-based functionals have…

Computational Physics · Physics 2025-01-22 Kirill Kulaev , Alexander Ryabov , Michael Medvedev , Evgeny Burnaev , Vladimir Vanovskiy

Machine learning approaches have the potential to approximate Density Functional Theory (DFT) for atomistic simulations in a computationally efficient manner, which could dramatically increase the impact of computational simulations on…

Computational Physics · Physics 2022-07-05 Joseph Musielewicz , Xiaoxiao Wang , Tian Tian , Zachary Ulissi

Graph neural networks have become a powerful framework for learning complex structure-property relationships and fast screening of chemical compounds. Recently proposed methods have demonstrated that using 3D geometry information of the…

Biomolecules · Quantitative Biology 2022-03-10 Ali Raza , E. Adrian Henle , Xiaoli Fern

Modeling electronic systems is an important application for quantum computers. In the context of materials science, an important open problem is the computational description of chemical reactions on surfaces. In this work, we outline a…

Geometry-aware optimization algorithms, such as Muon, have achieved remarkable success in training deep neural networks (DNNs). These methods leverage the underlying geometry of DNNs by selecting appropriate norms for different layers and…

Machine Learning · Computer Science 2026-02-04 Jie Hao , Xiaochuan Gong , Jie Xu , Zhengdao Wang , Mingrui Liu

Quantum mechanical methods like Density Functional Theory (DFT) are used with great success alongside efficient search algorithms for studying kinetics of reactive systems. However, DFT is prohibitively expensive for large scale…

Computational Physics · Physics 2022-09-02 Mathias Schreiner , Arghya Bhowmik , Tejs Vegge , Peter Bjørn Jørgensen , Ole Winther

The loss functions of deep neural networks are complex and their geometric properties are not well understood. We show that the optima of these complex loss functions are in fact connected by simple curves over which training and test…

Machine Learning · Statistics 2018-10-31 Timur Garipov , Pavel Izmailov , Dmitrii Podoprikhin , Dmitry Vetrov , Andrew Gordon Wilson

A molecule's geometry, also known as conformation, is one of a molecule's most important properties, determining the reactions it participates in, the bonds it forms, and the interactions it has with other molecules. Conventional…

Machine Learning · Computer Science 2020-01-01 Elman Mansimov , Omar Mahmood , Seokho Kang , Kyunghyun Cho

Accurate molecular geometries are a prerequisite for reliable quantum-chemical predictions, yet density functional theory (DFT) optimization remains a major bottleneck for high-throughput molecular screening. Here we present GeoOpt-Net, a…

Chemical Physics · Physics 2026-02-02 Chengchun Liu , Wendi Cai , Boxuan Zhao , Fanyang Mo

Artificial neural networks (NNs) are one of the most frequently used machine learning approaches to construct interatomic potentials and enable efficient large-scale atomistic simulations with almost ab initio accuracy. However, the…

Computational Physics · Physics 2021-10-05 Viktor Zaverkin , David Holzmüller , Ingo Steinwart , Johannes Kästner

Reduced-order simulation is an emerging method for accelerating physical simulations with high DOFs, and recently developed neural-network-based methods with nonlinear subspaces have been proven effective in diverse applications as more…

Machine Learning · Computer Science 2024-09-09 Aoran Lyu , Shixian Zhao , Chuhua Xian , Zhihao Cen , Hongmin Cai , Guoxin Fang

Understanding how structural flexibility affects the properties of metal-organic frameworks (MOFs) is crucial for the design of better MOFs for targeted applications. Flexible MOFs can be studied with molecular dynamics simulations, whose…

Materials Science · Physics 2024-05-13 Abhishek Sharma , Stefano Sanvito

Rapid advancements in machine learning (ML) are transforming materials science by significantly speeding up material property calculations. However, the proliferation of ML approaches has made it challenging for scientists to keep up with…

Machine Learning · Computer Science 2024-07-12 Ali Ramlaoui , Théo Saulus , Basile Terver , Victor Schmidt , David Rolnick , Fragkiskos D. Malliaros , Alexandre Duval

Ab initio molecular dynamics (AIMD) based on density functional theory (DFT) has become a workhorse for studying the structure, dynamics, and reactions in condensed matter systems. Currently, AIMD simulations are primarily carried out at…

Chemical Physics · Physics 2025-06-10 Ritama Kar , Sagarmoy Mandal , Vaishali Thakkur , Bernd Meyer , Nisanth N. Nair

The accuracy and efficiency of a coarse-grained (CG) force field are pivotal for high-precision molecular simulations of large systems with complex molecules. We present an automated mapping and optimization framework for molecular…

Computational Physics · Physics 2024-08-14 Zhixuan Zhong , Lifeng Xu , Jian Jiang
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