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This paper presents new results about the optimization based generation of chemical reaction networks (CRNs) of higher deficiency. Firstly, it is shown that the graph structure of the realization containing the maximal number of reactions…

Molecular Networks · Quantitative Biology 2011-03-23 Gabor Szederkenyi , Katalin M. Hangos , Tamas Peni

Energy functions for pure and heterogenous systems are one of the backbones for molecular simulation of condensed phase systems. With the advent of machine learned potential energy surfaces (ML-PESs) a new era has started. Statistical…

In this article we contribute to the moment analysis of branching processes in catalytic media. The many-to-few lemma based on the spine technique is used to derive a system of (discrete space) partial differential equations for the number…

Probability · Mathematics 2012-03-06 Leif Doering , Matthew I. Roberts

To unveil the logic of cell from a level of chemical reaction dynamics, we need to clarify how ensemble of chemicals can autonomously produce the set of chemical, without assuming a specific external control echanism. A cell consists of a…

Molecular Networks · Quantitative Biology 2007-05-23 Kunihiko Kaneko

Molecular circuits capable of autonomous learning could unlock novel applications in fields such as bioengineering and synthetic biology. To this end, existing chemical implementations of neural computing have mainly relied on emulating…

Machine Learning · Computer Science 2025-09-23 Rajiv Teja Nagipogu , John H. Reif

Quantum hydrodynamics is the emergent classical dynamics governing transport of conserved quantities in generic strongly-interacting quantum systems. Recent matrix product operator methods have made simulations of quantum hydrodynamics in…

Strongly Correlated Electrons · Physics 2022-09-30 Troy J. Sewell , Christopher David White

Chemical reaction network theory is a field of applied mathematics concerned with modeling chemical systems, and can be used in other contexts such as in systems biology to study cellular signaling pathways or epidemiology to study the…

Algebraic Geometry · Mathematics 2024-06-17 Maize Curiel , Elise Farr , Galileo Fries , Luis David García Puente , Julian Hutchins , Vuong Nguyen Hoang

Autocatalytic chemical reaction networks can collectively replicate or maintain their constituents despite degradation reactions only above a certain threshold, which we refer to as the decay threshold. When the chemical network has a…

Molecular Networks · Quantitative Biology 2025-11-17 Armand Despons , Jérémie Unterberger , David Lacoste

Petri Nets (PN) are widely used for modeling concurrent and distributed systems, but face challenges in modeling adaptive systems. To address this, we have formalized "rewritable" PT nets (RwPT) using Maude, a declarative language with…

Performance · Computer Science 2025-02-14 Lorenzo Capra

In the late 1970s, C.A. Petri introduced partially ordered event occurrences (runs), then called \emph{processes}, as the appropriate model to describe the individual evolutions of distributed systems. Here, we present a unified framework…

Logic in Computer Science · Computer Science 2026-02-13 Peter Fettke , Wolfgang Reisig

Reversing Petri nets (RPNs) have recently been proposed as a net-basedapproach to model causal and out-of-causal order reversibility. They are based on the notion of individual tokens that can be connected together via bonds. In this paper…

Logic in Computer Science · Computer Science 2022-09-07 Anna Philippou , Kyriaki Psara

An inverse problem framework for constructing reaction systems with prescribed properties is presented. Kinetic transformations are defined and analysed as a part of the framework, allowing an arbitrary polynomial ordinary differential…

Dynamical Systems · Mathematics 2015-10-27 Tomislav Plesa , Tomas Vejchodsky , Radek Erban

Informally, a chemical reaction network is "atomic" if each reaction may be interpreted as the rearrangement of indivisible units of matter. There are several reasonable definitions formalizing this idea. We investigate the computational…

Computational Complexity · Computer Science 2017-10-03 David Doty , Shaopeng Zhu

Developing accurate models for chemical reactors is often challenging due to the complexity of reaction kinetics and process dynamics. Traditional approaches require retraining models for each new system, limiting generalizability and…

Computational Engineering, Finance, and Science · Computer Science 2025-05-29 Zihao Wang , Zhe Wu

We classify all additive invariants of open Petri nets: these are $\mathbb{N}$-valued invariants which are additive with respect to sequential and parallel composition of open Petri nets. In particular, we prove two classification theorems:…

Category Theory · Mathematics 2025-07-30 Benjamin Merlin Bumpus , Sophie Libkind , Jordy Lopez Garcia , Layla Sorkatti , Samuel Tenka

In living cells, biochemical reactions are catalyzed by specific enzymes and connect to one another by sharing substrates and products, forming complex networks. In our previous studies, we established a framework determining the responses…

Molecular Networks · Quantitative Biology 2017-09-06 Takashi Okada , Atsushi Mochizuki

The analysis of biological networks has benefited from the richness of Boolean networks (BNs) and the associated theory. These results have been further fortified in recent years by the emergence of Most Permissive (MP) semantics, combining…

Discrete Mathematics · Computer Science 2025-05-26 Stefan Haar , Juri Kolčák

We investigate bisimulation equivalence on Petri nets under durational semantics. Our motivation was to verify the conjecture that in durational setting, the bisimulation equivalence checking problem becomes more tractable than in ordinary…

Computational Complexity · Computer Science 2015-06-29 Slawomir Lasota , Marcin Poturalski

This article characterizes certain small multistationary chemical reaction networks. We consider the set of fully open networks, those for which all chemical species participate in inflow and outflow, containing one non-flow (reversible or…

Dynamical Systems · Mathematics 2013-01-18 Badal Joshi

Reversible computations constitute an unconventional form of computing where any sequence of performed operations can be undone by executing in reverse order at any point during a computation. It has been attracting increasing attention as…

Computation and Language · Computer Science 2023-06-22 Kamila Barylska , Anna Gogolińska