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In times of outbreaks, an essential requirement for better monitoring is the evaluation of the number of undiagnosed infected individuals. An accurate estimate of this fraction is crucial for the assessment of the situation and the…

Populations and Evolution · Quantitative Biology 2021-03-17 Akiva B. Melka , Yoram Louzoun

Understanding the number of individuals who have been infected with the novel coronavirus SARS-CoV-2, and the extent to which social distancing policies have been effective at limiting its spread, are critical for effective policy going…

Applications · Statistics 2020-04-21 James Johndrow , Kristian Lum , Maria Gargiulo , Patrick Ball

There are many sources of data giving information about the number of SARS-CoV-2 infections in the population, but all have major drawbacks, including biases and delayed reporting. For example, the number of confirmed cases largely…

Applications · Statistics 2022-06-08 Nicholas J. Irons , Adrian E. Raftery

Since the beginning of March 2020, the cumulative numbers of cases of infection with the novel coronavirus SARS-CoV-2 in Germany have been reported on a daily basis. The reports originate from national laws, according to which positive test…

Populations and Evolution · Quantitative Biology 2020-05-08 Ralph Brinks , Annika Hoyer

As a consequence of missing data on tests for infection and imperfect accuracy of tests, reported rates of population infection by the SARS CoV-2 virus are lower than actual rates of infection. Hence, reported rates of severe illness…

Econometrics · Economics 2020-04-27 Charles F. Manski , Francesca Molinari

SARS-CoV-2 has disrupted the life of billions of people around the world since the first outbreak was officially declared in China at the beginning of 2020. Yet, important questions such as how deadly it is or its degree of spread within…

Populations and Evolution · Quantitative Biology 2021-03-01 Beatriz Seoane

Understanding how widely COVID-19 has spread is critical for examining the pandemic's progression. Despite efforts to carefully monitor the pandemic, the number of confirmed cases may underestimate the total number of infections. We…

Populations and Evolution · Quantitative Biology 2020-05-27 Christina Bohk-Ewald , Christian Dudel , Mikko Myrskylä

The COVID-19 pandemic has caused major disturbance to human life. An important reason behind the widespread social anxiety is the huge uncertainty about the pandemic. A fundamental uncertainty is how many or what percentage of people have…

Populations and Evolution · Quantitative Biology 2021-03-04 Donghui Yan , Ying Xu , Pei Wang

Large-scale testing is considered key to assess the state of the current COVID-19 pandemic. Yet, the link between the reported case numbers and the true state of the pandemic remains elusive. We develop mathematical models based on…

Applications · Statistics 2021-02-04 Michel Besserve , Simon Buchholz , Bernhard Schölkopf

Measuring the prevalence of active SARS-CoV-2 infections in the general population is difficult because tests are conducted on a small and non-random segment of the population. However, people admitted to the hospital for non-COVID reasons…

Econometrics · Economics 2021-03-23 Daniel W. Sacks , Nir Menachemi , Peter Embi , Coady Wing

Countries officially record the number of COVID-19 cases based on medical tests of a subset of the population with unknown participation bias. For prevalence estimation, the official information is typically discarded and, instead, small…

Methodology · Statistics 2020-12-25 Stéphane Guerrier , Christoph Kuzmics , Maria-Pia Victoria-Feser

Having accurate and timely data on confirmed active COVID-19 cases is challenging, since it depends on testing capacity and the availability of an appropriate infrastructure to perform tests and aggregate their results. In this paper, we…

An urgent problem in controlling COVID-19 spreading is to understand the role of undocumented infection. We develop a five-state model for COVID-19, taking into account the unique features of the novel coronavirus, with key parameters…

Populations and Evolution · Quantitative Biology 2020-03-27 Yong-Shang Long , Zheng-Meng Zhai , Li-Lei Han , Jie Kang , Yi-Lin Li , Zhao-Hua Lin , Lang Zeng , Da-Yu Wu , Chang-Qing Hao , Ming Tang , Zonghua Liu , Ying-Cheng Lai

The discovery of SARS-CoV-2, the responsible virus for the Covid-19 epidemic, has sparked a global health concern with many countries affected. Developing models that can interpret the epidemic and give common trend parameters are useful…

Populations and Evolution · Quantitative Biology 2021-09-21 Milad Radiom , Jean-Franccois Berret

One of the key indicators used in tracking the evolution of an infectious disease isthe reproduction number. This quantity is usually computed using the reportednumber of cases, but ignoring that many more individuals may be infected…

Populations and Evolution · Quantitative Biology 2020-09-11 Andrea De Simone , Marco Piangerelli

The current SARS-CoV-2 pandemic is a harsh reminder of the fact that, whether in a single human host or a wave of infection across continents, viral dynamics is often a story about the numbers. In this snapshot, our aim is to provide a…

Other Quantitative Biology · Quantitative Biology 2020-04-01 Yinon M. Bar-On , Avi I. Flamholz , Rob Phillips , Ron Milo

Using recent data from voluntary mass testing, I provide credible bounds on prevalence of SARS-CoV-2 for Austrian counties in early December 2020. When estimating prevalence, a natural missing data problem arises: no test results are…

General Economics · Economics 2020-12-23 Gabriel Ziegler

More than any other infectious disease epidemic, the COVID-19 pandemic has been characterized by the generation of large volumes of viral genomic data at an incredible pace due to recent advances in high-throughput sequencing technologies,…

Accurate forecasts for COVID-19 are necessary for better preparedness and resource management. Specifically, deciding the response over months or several months requires accurate long-term forecasts which is particularly challenging as the…

Populations and Evolution · Quantitative Biology 2020-07-10 Ajitesh Srivastava , Viktor K. Prasanna

When the novel coronavirus disease SARS-CoV2 (COVID-19) was officially declared a pandemic by the WHO in March 2020, the scientific community had already braced up in the effort of making sense of the fast-growing wealth of data gathered by…

Populations and Evolution · Quantitative Biology 2020-05-25 Timoteo Carletti , Duccio Fanelli , Francesco Piazza
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