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Optimizing the mRNA codon has an essential impact on gene expression for a specific target protein. It is an NP-hard problem; thus, exact solutions to such optimization problems become computationally intractable for realistic problem sizes…

Quantum Physics · Physics 2024-05-13 Hongfeng Zhang , Aritra Sarkar , Koen Bertels

Variational Quantum Algorithms (VQAs) are a class of hybrid quantum-classical algorithms that leverage on classical optimization tools to find the optimal parameters for a parameterized quantum circuit. One relevant application of VQAs is…

Quantum Physics · Physics 2026-01-26 Mirko Legnini , Julian Berberich

Currently available quantum computers suffer from constraints including hardware noise and a limited number of qubits. As such, variational quantum algorithms that utilise a classical optimiser in order to train a parameterised quantum…

Quantum Physics · Physics 2023-04-18 Samuel Duffield , Marcello Benedetti , Matthias Rosenkranz

In this study, we propose a new method for constrained combinatorial optimization using variational quantum circuits. Quantum computers are considered to have the potential to solve large combinatorial optimization problems faster than…

Quantum Physics · Physics 2025-07-15 Hyakka Nakada , Kotaro Tanahashi , Shu Tanaka

The application of quantum annealing to the optimization of continuous-variable functions is a relatively unexplored area of research. We test the performance of quantum annealing applied to a one-dimensional continuous-variable function…

Quantum Physics · Physics 2023-10-06 Shunta Arai , Hiroki Oshiyama , Hidetoshi Nishimori

In this report, we propose a novel quantum diagonalization algorithm based on the optimization of variational quantum circuits. Diagonalizing a quantum state is a fundamental yet computationally challenging task in quantum information…

Quantum Physics · Physics 2025-05-23 Juan Yao

We present a new optimization method for small-to-intermediate scale variational algorithms on noisy near-term quantum processors which uses a Gaussian process surrogate model equipped with a classically-evaluated quantum kernel.…

Quantum Physics · Physics 2023-08-16 Alistair W. R. Smith , A. J. Paige , M. S. Kim

We present superconducting quantum circuits which exhibit atomic energy spectrum and selection rules as ladder and lambda three-level configurations designed by means of genetic algorithms. These heuristic optimization techniques are…

Quantum Physics · Physics 2025-06-17 F. A. Cárdenas-López , J. C. Retamal , Xi Chen , G. Romero , M. Sanz

Simulation of quantum many-body systems is a promising application of quantum computers. However, implementing the time-evolution operator as a quantum circuit efficiently on near-term devices with limited resources is challenging. Standard…

Optimizing open quantum system evolution is an important step on the way to achieving quantum computing and quantum thermodynamic tasks. In this article, we approach optimisation via variational principles and derive an open quantum system…

Quantum Physics · Physics 2018-10-17 Nishchay Suri , Felix C. Binder , Bhaskaran Muralidharan , Sai Vinjanampathy

Quantum process characterization is a fundamental task in quantum information processing, yet conventional methods, such as quantum process tomography, require prohibitive resources and lack scalability. Here, we introduce an efficient…

Quantum Physics · Physics 2025-04-11 Yusen Wu , Yukun Zhang , Chuan Wang , Xiao Yuan

The simulation of many-body open quantum systems is key to solving numerous outstanding problems in physics, chemistry, material science, and in the development of quantum technologies. Near-term quantum computers may bring considerable…

Quantum Physics · Physics 2025-02-05 Sara Santos , Xinyu Song , Vincenzo Savona

Variational quantum algorithms have emerged as a powerful tool for harnessing the potential of near-term quantum devices to address complex challenges across quantum science and technology. Yet, the robust and scalable quantification of…

Quantum Physics · Physics 2025-10-21 Vahid Azimi-Mousolou , Prashant Singh

We investigate the challenge of classical simulation of unitary quantum dynamics with variational Monte Carlo approaches, addressing the instabilities and high computational demands of existing methods. By systematically analyzing the…

Quantum Physics · Physics 2025-07-30 Luca Gravina , Vincenzo Savona , Filippo Vicentini

The emerging paradigm of distributed quantum computing promises a potential solution to scaling quantum computing to currently unfeasible dimensions. While this approach itself is still in its infancy, and many obstacles must still be…

Quantum Physics · Physics 2026-01-26 Leo Sünkel , Jonas Stein , Maximilian Zorn , Thomas Gabor , Claudia Linnhoff-Popien

With rapid advancements in machine learning, first-order algorithms have emerged as the backbone of modern optimization techniques, owing to their computational efficiency and low memory requirements. Recently, the connection between…

Quantum Physics · Physics 2025-05-21 Jiaqi Leng , Bin Shi

We introduce a new discrete-time variational principle inspired by the quantum clock originally proposed by Feynman, and use it to write down quantum evolution as a ground state eigenvalue problem. The construction allows one to apply…

Quantum Physics · Physics 2014-03-05 Jarrod R. McClean , John A. Parkhill , Alán Aspuru-Guzik

We propose a neural-network variational quantum algorithm to simulate the time evolution of quantum many-body systems. Based on a modified restricted Boltzmann machine (RBM) wavefunction ansatz, the proposed algorithm can be efficiently…

Quantum Physics · Physics 2021-05-12 Chee-Kong Lee , Pranay Patil , Shengyu Zhang , Chang-Yu Hsieh

There has been intensive research on increasing the utility and performance of Parameterized Quantum Circuits (PQCs) in the past couple of years. Owing to this research, there are now several inductive biases available to a quantum…

Quantum Physics · Physics 2026-04-24 Ankit Kulshrestha , Sarvagya Upadhyay

Simulating the dynamics of open quantum systems is a crucial task in quantum computing, offering wide-ranging applications but remaining computationally challenging. In this paper, we propose two quantum algorithms for simulating the…

Quantum Physics · Physics 2025-10-29 Sirui Peng , Xiaoming Sun , Qi Zhao , Hongyi Zhou
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