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A pervasive challenge in neuroscience is testing whether neuronal connectivity changes over time due to specific causes, such as stimuli, events, or clinical interventions. Recent hardware innovations and falling data storage costs enable…

Neurons and Cognition · Quantitative Biology 2024-01-05 Johan Medrano , Karl J. Friston , Peter Zeidman

Learning and interpreting the structure of the environment is an innate feature of biological systems, and is integral to guiding flexible behaviours for evolutionary viability. The concept of a cognitive map has emerged as one of the…

Neurons and Cognition · Quantitative Biology 2022-02-04 James C. R. Whittington , David McCaffary , Jacob J. W. Bakermans , Timothy E. J. Behrens

Many biological systems regulate phenotypic heterogeneity as a fitness-maximising strategy in uncertain and dynamic environments. Analysis of such strategies is typically confined both to a discrete set of environmental conditions, and to a…

Populations and Evolution · Quantitative Biology 2025-07-02 Alexander P Browning , Sara Hamis

Computational modeling plays an increasingly important role in neuroscience, highlighting the philosophical question of how computational models explain. In the context of neural network models for neuroscience, concerns have been raised…

Neurons and Cognition · Quantitative Biology 2021-04-15 Rosa Cao , Daniel Yamins

A growing body of research indicates that structural plasticity mechanisms are crucial for learning and memory consolidation. Starting from a simple phenomenological model, we exploit a mean-field approach to develop a theoretical framework…

Neurons and Cognition · Quantitative Biology 2024-06-19 Gianmarco Tiddia , Luca Sergi , Bruno Golosio

A large repertoire of spatiotemporal activity patterns in the brain is the basis for adaptive behaviour. Understanding the mechanism by which the brain's hundred billion neurons and hundred trillion synapses manage to produce such a range…

Neurons and Cognition · Quantitative Biology 2010-10-14 Dante R. Chialvo

Preferences of individuals are distributions of elements generated by generalized functions. Models of economic decision-making derived from such distributions are consistent with results of physiological experiments, and explain any…

Neurons and Cognition · Quantitative Biology 2012-01-20 Leonid A. Shapiro

How subjective experience (i.e., consciousness) arises out of objective material processes has been called the hard problem. The neuroscience of consciousness has set out to find the sufficient conditions for consciousness and theoretical…

Neurons and Cognition · Quantitative Biology 2023-11-17 Peter Coppola

Nested Effects Models (NEMs) are a class of graphical models introduced to analyze the results of gene perturbation screens. NEMs explore noisy subset relations between the high-dimensional outputs of phenotyping studies, e.g. the effects…

Quantitative Methods · Quantitative Biology 2010-10-08 Achim Tresch , Florian Markowetz

Neurosymbolic Programming (NP) techniques have the potential to accelerate scientific discovery. These models combine neural and symbolic components to learn complex patterns and representations from data, using high-level concepts or known…

A core goal of functional neuroimaging is to study how the environment is processed in the brain. The mainstream paradigm involves concurrently measuring a broad spectrum of brain responses to a small set of environmental features…

Neurons and Cognition · Quantitative Biology 2021-06-14 Pedro F. da Costa , Rianne Haartsen , Elena Throm , Luke Mason , Anna Gui , Robert Leech , Emily J. H. Jones

The functioning of an organ such as the brain emerges from interactions between its constituent parts. Further, this interaction is not immutable in time but rather unfolds in a succession of patterns, thereby allowing the brain to adapt to…

Neurons and Cognition · Quantitative Biology 2021-06-02 Emmanuelle Tognoli , Daniela Benites , J. A. Scott Kelso

Understanding how decision making changes across the lifespan is a central challenge for neuroscience, yet research on cognitive aging has remained largely disconnected from the theoretical and computational advances that now shape modern…

Neurons and Cognition · Quantitative Biology 2026-03-04 Michael B. Ryan , Letizia Ye , Anne K. Churchland

Current concerns over reforming engineering education have focused attention on helping students develop skills and an adaptive expertise. Phenomenological guidelines for instruction along these lines can be understood as arising out of an…

Physics Education · Physics 2012-09-05 Edward F. Redish , Karl A. Smith

Large-scale neuroscience is generating rich datasets across animals, brain areas and behavioral contexts, yet our modeling efforts remains fragmented across isolated experiments. We argue that understanding behavior requires integrative…

Neuroscience is undergoing dramatic progress because of the vast data streams derived from the new technologies product of the BRAIN initiative and other enterprises. As any other scientific field, neuroscience benefits from having clear…

Neurons and Cognition · Quantitative Biology 2022-09-22 Horacio G. Rotstein , Fidel Santamaria

In spite of the large amount of existing neural models in the literature, there is a lack of a systematic review of the possible effect of choosing different initial conditions on the dynamic evolution of neural systems. In this short…

Neurons and Cognition · Quantitative Biology 2016-05-24 Pedro A. Valdes-Hernandez , Thomas Knoesche

Physical learning is an emerging paradigm in science and engineering whereby (meta)materials acquire desired macroscopic behaviors by exposure to examples. So far, it has been applied to static properties such as elastic moduli and…

Cognitive neuroscience methods can identify the fMRI-measured neural representation of familiar individual concepts, such as apple, and decompose them into meaningful neural and semantic components. This approach was applied here to…

Neurons and Cognition · Quantitative Biology 2021-10-15 Robert A. Mason , Reinhard A. Schumacher , Marcel A. Just

Learning and the ability to learn are important factors in development and evolutionary processes [1]. Depending on the level, the complexity of learning can strongly vary. While associative learning can explain simple learning behaviour…

Neurons and Cognition · Quantitative Biology 2007-05-23 Reimer Kuehn , Ion-Olimpiu Stamatescu