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High-throughput screening, in which multiwell plates are used to test large numbers of compounds against specific targets, is widely used across many areas of the biological sciences and most prominently in drug discovery. We propose a…

X-ray free-electron lasers are sources of coherent, high-intensity X-rays with numerous applications in ultra-fast measurements and dynamic structural imaging. Due to the stochastic nature of the self-amplified spontaneous emission process…

We present the first evaluation of a recently developed silicon-strip detector for photon-counting dual-energy breast tomosynthesis. The detector is well suited for tomosynthesis with high dose efficiency and intrinsic scatter rejection. A…

Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs. Previously, it has been shown that combining phase retrieval with…

X-ray microtomography at synchrotron sources is fundamentally limited by the high radiation dose applied to the samples, which restricts investigations to non-native tissue states and thereby compromises the biological relevance of the…

The multiplexing capabilities of superconducting X-ray free-electron lasers (FELs) have gained much attention in recent years. The demanding requirements for photon properties from multiple undulator lines necessitate more flexible beam…

Accelerator Physics · Physics 2023-03-20 Zhen Zhang , Yuantao Ding , Zhirong Huang , Feng Zhou

We propose a novel scheme for the population and depletion of nuclear isomers. The scheme combines the $\gamma$-photons with energies $\gtrsim 10$ keV emitted during the interaction of a contemporary high-intensity laser pulse with a plasma…

Nuclear Theory · Physics 2025-07-25 C. -J. Yang , K. M. Spohr , M. Cernaianu , D. Doria , P. Ghenuche , V. Horny

The design of low-profile linear microstrip arrays with wide-band spatial filtering capabilities is dealt with. An innovative architecture, leveraging the angular selectivity of offset stacked patch (OSP) radiators, is proposed to implement…

Signal Processing · Electrical Eng. & Systems 2024-06-26 Arianna Benoni , Marco Salucci , Andrea Massa

Quality control in molecular optical sectioning microscopy is indispensable for transforming acquired digital images from qualitative descriptions to quantitative data. Although numerous tools, metrics, and phantoms have been developed,…

Multi-beam ptychography (MBP) offers a scalable solution to improve the throughput of state-of-the-art ptychography by increasing the number of coherent beams that illuminate the sample simultaneously. However, increasing the number of…

Optics · Physics 2025-10-29 Runqing Yang , Pablo Villanueva-Perez , Maik Kahnt

The spectrum of laser-plasma generated X-rays is very important, it characterizes electron dynamics in plasma and is basic for applications. However, the accuracies and efficiencies of existing methods to diagnose the spectrum of…

Instrumentation and Detectors · Physics 2021-09-03 Jiaxing Wen , Minghai Yu , Yuchi Wu , Ming Zeng , Bo Zhang , Jirong Cang , Yuge Zhang , Ge Ma , Yue Yang , Wenbo Mo , Zongqing Zhao

We propose a novel technique to refine the modelling of galaxy clusters mass distribution using gravitational lensing. The idea is to combine the strengths of both "parametric" and "non-parametric" methods to improve the quality of the fit.…

Cosmology and Nongalactic Astrophysics · Physics 2009-11-13 Eric Jullo , Jean-Paul Kneib

The use of large, X-ray selected galaxy cluster catalogues for cosmological analyses requires a thorough understanding of the X-ray mass estimates. Weak gravitational lensing is an ideal method to shed light on such issues, due to its…

Cosmology and Nongalactic Astrophysics · Physics 2017-04-05 Melanie Simet , Nicholas Battaglia , Rachel Mandelbaum , Uroš Seljak

To combat the risk of nuclear smuggling, radiography systems are deployed at ports to scan cargo containers for concealed illicit materials. Dual energy radiography systems enable a rough elemental analysis of cargo containers due to the…

Nuclear Experiment · Physics 2024-04-17 Peter Lalor , Areg Danagoulian

Polarization plays an important role in various time-domain astrophysics to understand the magnetic fields, geometry, and environments of spatially unresolved variable sources. In this paper we present the results of laboratory and on-sky…

Instrumentation and Methods for Astrophysics · Physics 2020-04-29 Manisha Shrestha , Iain A. Steele , Andrez S. Piascik , Helen Jermak , Robert J. Smith , Chris M. Copperwheat

Scintillators convert X-ray energy into visible or near-visible photons, enabling applications in high-energy particle detection and X-ray imaging. Increasing scintillator thickness improves X-ray absorption but degrades spatial resolution…

Optics · Physics 2026-05-19 Seou Choi , Sachin Vaidya , Charles Roques-Carmes , Marin Soljačić

We demonstrate that powder diffraction data can be collected from sub-micron crystals of a mbrane protein with nearly two orders of magnitude more atoms than the molecules commonly used for powder diffraction. The crystals of photosystem-1…

This is the third in a series of papers that develop a new and flexible model to predict weak-lensing (WL) peak counts, which have been shown to be a very valuable non-Gaussian probe of cosmology. In this paper, we compare the cosmological…

Cosmology and Nongalactic Astrophysics · Physics 2016-10-03 Chieh-An Lin , Martin Kilbinger , Sandrine Pires

We construct a linear filter optimised for detecting dark-matter halos in weak-lensing data. The filter assumes a mean radial profile of the halo shear pattern and modifies that shape by the noise power spectrum. Aiming at separating…

Astrophysics · Physics 2009-11-10 M. Maturi , M. Meneghetti , M. Bartelmann , K. Dolag , L. Moscardini

An ideal plasma lens can provide the focusing power of a small f-number, solid-state focusing optic at a fraction of the diameter. An ideal plasma lens, however, relies on a steady-state, linear laser pulse-plasma interaction. Ultrashort…

Plasma Physics · Physics 2016-01-20 J. P. Palastro , D. Gordon , B. Hafizi , L. A. Johnson , J. Penano , R. F. Hubbard , M. Helle , D. Kaganovich
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