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Generating molecules with desired chemical properties presents a critical challenge in fields such as chemical synthesis and drug discovery. Recent advancements in artificial intelligence (AI) and deep learning have significantly…

Machine Learning · Computer Science 2025-09-25 Chen Li , Huidong Tang , Ye Zhu , Yoshihiro Yamanishi

The potential advantage of machine learning in quantum computers is a topic of intense discussion in the literature. Theoretical, numerical and experimental explorations will most likely be required to understand its power. There has been…

Quantum Physics · Physics 2021-04-05 Abhinav Anand , Jonathan Romero , Matthias Degroote , Alán Aspuru-Guzik

Drug discovery is lengthy and expensive, with traditional computer-aided design facing limits. This paper examines integrating quantum computing across the drug development cycle to accelerate and enhance workflows and rigorous…

Generative Adversarial Nets (GANs) represent an important milestone for effective generative models, which has inspired numerous variants seemingly different from each other. One of the main contributions of this paper is to reveal a…

Machine Learning · Statistics 2017-05-10 Jae Hyun Lim , Jong Chul Ye

The Research & Development (R&D) phase of drug development is a lengthy and costly process. To revolutionize this process, we introduce our new concept QMLS to shorten the whole R&D phase to three to six months and decrease the cost to…

Biomolecules · Quantitative Biology 2024-09-06 Yifan Zhou , Yan Shing Liang , Yew Kee Wong , Haichuan Qiu , Yu Xi Wu , Bin He

Generative adversarial networks (GANs) have achieved remarkable success with realistic tasks such as creating realistic images, texts, and audio. Combining GANs and quantum computing, quantum GANs are thought to have an exponential…

Quantum Physics · Physics 2024-12-04 Haoran Ma , Liao Ye , Fanjie Ruan , Zichao Zhao , Maohui Li , Yuehai Wang , Jianyi Yang

Quantum machine learning holds the promise of harnessing quantum advantage to achieve speedup beyond classical algorithms. Concurrently, research indicates that dissipation can serve as an effective resource in quantum computation. In this…

Quantum Physics · Physics 2024-08-29 He Wang , Jin Wang

In this work, we introduce Auxiliary Discriminator Sequence Generative Adversarial Networks (ADSeqGAN), a novel approach for molecular generation in small-sample datasets. Traditional generative models often struggle with limited training…

Machine Learning · Computer Science 2025-09-15 Haocheng Tang , Jing Long , Beihong Ji , Junmei Wang

Quantum computing offers fundamentally more expressive mechanisms for generative modeling, yet current approaches remain constrained by classical neural components that bottleneck quantum capability and hardware efficiency. We propose the…

Quantum Physics · Physics 2025-10-06 Yihua Li , Jiayi Chen , Tamanna S. Kumavat , Kyriakos Flouris

Recent methods for generating novel molecules use graph representations of molecules and employ various forms of graph convolutional neural networks for inference. However, training requires solving an expensive graph isomorphism problem,…

Machine Learning · Computer Science 2021-03-02 Sebastian Pölsterl , Christian Wachinger

Generative adversarial networks (GANs) provide an algorithmic framework for constructing generative models with several appealing properties: they do not require a likelihood function to be specified, only a generating procedure; they…

Machine Learning · Statistics 2017-02-28 Shakir Mohamed , Balaji Lakshminarayanan

High-multiplicity all-hadronic final states are an important, but difficult final state for searching for physics beyond the Standard Model. A powerful search method is to look for large jets with accidental substructure due to multiple…

High Energy Physics - Phenomenology · Physics 2019-06-26 Joshua Lin , Wahid Bhimji , Benjamin Nachman

Protein-ligand binding affinity is critical in drug discovery, but experimentally determining it is time-consuming and expensive. Artificial intelligence (AI) has been used to predict binding affinity, significantly accelerating this…

Emerging Technologies · Computer Science 2025-09-16 Seon-Geun Jeong , Kyeong-Hwan Moon , Won-Joo Hwang

Modeling financial time series by stochastic processes is a challenging task and a central area of research in financial mathematics. As an alternative, we introduce Quant GANs, a data-driven model which is inspired by the recent success of…

Mathematical Finance · Quantitative Finance 2020-04-07 Magnus Wiese , Robert Knobloch , Ralf Korn , Peter Kretschmer

One of the main challenges in drug discovery is to find molecules that bind specifically and strongly to their target protein while having minimal binding to other proteins. By predicting binding affinity, it is possible to identify the…

Quantum Physics · Physics 2023-01-19 L. Domingo , M. Djukic , C. Johnson , F. Borondo

Deep learning algorithms produces state-of-the-art results for different machine learning and computer vision tasks. To perform well on a given task, these algorithms require large dataset for training. However, deep learning algorithms…

Machine Learning · Computer Science 2019-04-03 Talha Iqbal , Hazrat Ali

The computation of dynamical correlators of quantum many-body systems represents an open critical challenge in condensed matter physics. While powerful methodologies have risen in recent years, covering the full parameter space remains…

Strongly Correlated Electrons · Physics 2022-11-15 Rouven Koch , Jose L. Lado

Deep generative models, such as generative adversarial networks (GANs), are pivotal in discovering novel drug-like candidates via de novo molecular generation. However, traditional character-wise tokenizers often struggle with identifying…

Machine Learning · Computer Science 2024-10-01 Huidong Tang , Chen Li , Yasuhiko Morimoto

Generative models and in particular Generative Adversarial Networks (GANs) have become very popular and powerful data generation tool. In recent years, major progress has been made in extending this concept into the quantum realm. However,…

Quantum Physics · Physics 2023-09-19 Wiktor Jurasz , Christian B. Mendl

The field of drug discovery hinges on the accurate prediction of binding affinity between prospective drug molecules and target proteins, especially when such proteins directly influence disease progression. However, estimating binding…

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