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This paper adds to the growing literature of reinforcement learning (RL) for healthcare by proposing a novel paradigm: augmenting any predictor with Rule-based RL Layer (RRLL) that corrects the model's physiologically impossible…

Machine Learning · Computer Science 2025-02-03 Lingwei Zhu , Zheng Chen , Yukie Nagai , Jimeng Sun

Existing studies on reinforcement learning (RL) for sepsis management have mostly followed an established problem setup, in which patient data are aggregated into 4-hour time steps. Although concerns have been raised regarding the…

Machine Learning · Computer Science 2025-11-27 Yingchuan Sun , Shengpu Tang

A common concern when a policymaker draws causal inferences from and makes decisions based on observational data is that the measured covariates are insufficiently rich to account for all sources of confounding, i.e., the standard no…

Methodology · Statistics 2023-10-25 Tao Shen , Yifan Cui

Observational longitudinal studies are a common means to study treatment efficacy and safety in chronic mental illness. In many such studies, treatment changes may be initiated by either the patient or by their clinician and can thus vary…

Methodology · Statistics 2020-06-12 Zekun Xu , Eric Laber , Ana-Maria Staicu , Emanuel Severus

To tackle interpretability in deep learning, we present a novel framework to jointly learn a predictive model and its associated interpretation model. The interpreter provides both local and global interpretability about the predictive…

Machine Learning · Computer Science 2022-02-24 Jayneel Parekh , Pavlo Mozharovskyi , Florence d'Alché-Buc

Background. Treatment selection for low to intermediate risk patients with severe aortic stenosis between surgical (SAVR) and transcatheter (TAVR) aortic valve replacement remains variable in clinical practice, driven by patient…

Supervised machine learning often operates on the data-driven paradigm, wherein internal model parameters are autonomously optimized to converge predicted outputs with the ground truth, devoid of explicitly programming rules or a priori…

Machine Learning · Computer Science 2024-12-12 Daniel Geissler , Bo Zhou , Mengxi Liu , Paul Lukowicz

The ability to interpret machine learning model decisions is critical in such domains as healthcare, where trust in model predictions is as important as their accuracy. Inspired by the development of prototype parts-based deep neural…

Machine Learning · Computer Science 2026-03-06 Jacek Karolczak , Jerzy Stefanowski

As a paradigm for sequential decision making in unknown environments, reinforcement learning (RL) has received a flurry of attention in recent years. However, the explosion of model complexity in emerging applications and the presence of…

Machine Learning · Statistics 2025-07-22 Yuejie Chi , Yuxin Chen , Yuting Wei

In supervised learning for medical image analysis, sample selection methodologies are fundamental to attain optimum system performance promptly and with minimal expert interactions (e.g. label querying in an active learning setup). In this…

Computer Vision and Pattern Recognition · Computer Science 2021-04-14 Dwarikanath Mahapatra

Pretraining multimodal models on Electronic Health Records (EHRs) provides a means of learning representations that can transfer to downstream tasks with minimal supervision. Recent multimodal models induce soft local alignments between…

Machine Learning · Computer Science 2023-02-27 Denis Jered McInerney , Geoffrey Young , Jan-Willem van de Meent , Byron C. Wallace

An individualized treatment rule (ITR) tailors treatments to a patient's specific characteristics. However, randomized controlled trials (RCTs) are often underpowered to detect the treatment effect heterogeneity needed for reliable ITR…

Methodology · Statistics 2026-04-14 Yuan Bian , Donglin Zeng , Hyun-Joon Yang , Leanne M. Williams , Yuanjia Wang

Reinforcement learning (RL) agents performing complex tasks must be able to remember observations and actions across sizable time intervals. This is especially true during the initial learning stages, when exploratory behaviour can increase…

Machine Learning · Computer Science 2018-05-15 Thomas Stepleton , Razvan Pascanu , Will Dabney , Siddhant M. Jayakumar , Hubert Soyer , Remi Munos

Synthesizing information from multiple data sources is crucial for constructing accurate individualized treatment rules (ITRs). However, privacy concerns often present significant barriers to the integrative analysis of such multi-source…

Methodology · Statistics 2025-11-11 Nan Qiao , Wangcheng Li , Jingxiao Zhang , Canyi Chen

Harness engineering has emerged as an important inference-time technique for large language model (LLM) agents, aiming to improve long-term performance through task decomposition and guided execution. However, more elaborate harnesses are…

Machine Learning · Computer Science 2026-05-22 Boyuan Wang , Bochao Li , Minghan Wang , Yuxin Tao , Fang Kong

Many statistical models have high accuracy on test benchmarks, but are not explainable, struggle in low-resource scenarios, cannot be reused for multiple tasks, and cannot easily integrate domain expertise. These factors limit their use,…

Computation and Language · Computer Science 2021-09-29 Andrew Lee , Jonathan K. Kummerfeld , Lawrence C. An , Rada Mihalcea

Recent advancements in explainable machine learning provide effective and faithful solutions for interpreting model behaviors. However, many explanation methods encounter efficiency issues, which largely limit their deployments in practical…

Machine Learning · Computer Science 2023-03-07 Yu-Neng Chuang , Guanchu Wang , Fan Yang , Quan Zhou , Pushkar Tripathi , Xuanting Cai , Xia Hu

This paper studies the control synthesis of motion planning subject to uncertainties. The uncertainties are considered in robot motions and environment properties, giving rise to the probabilistic labeled Markov decision process (PL-MDP). A…

Robotics · Computer Science 2023-01-31 Mingyu Cai , Shaoping Xiao , Zhijun Li , Zhen Kan

Dataset distillation compresses a large dataset into a small synthetic dataset such that learning on the synthetic dataset approximates learning on the original. Training on the distilled dataset can be performed in as little as one step of…

Machine Learning · Computer Science 2025-08-14 Connor Wilhelm , Dan Ventura

Decision trees are ubiquitous in machine learning for their ease of use and interpretability. Yet, these models are not typically employed in reinforcement learning as they cannot be updated online via stochastic gradient descent. We…

Machine Learning · Computer Science 2020-06-29 Andrew Silva , Taylor Killian , Ivan Dario Jimenez Rodriguez , Sung-Hyun Son , Matthew Gombolay
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